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Transforming Activities of JC Virus Early Proteins

  • Richard J. Frisque
  • Catherine Hofstetter
  • Shiva K. Tyagarajan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 577)

Abstract

Polyomaviruses, as their name indicates, are viruses capable of inducing a variety of tumors in vivo. Members of this family, including the human JC and BK viruses (JCV, BKV), and the better characterized mouse polyomavirus and simian virus 40 (SV40), are small DNA viruses that commandeer a cell’s molecular machinery to reproduce themselves. Studies of these virus-host interactions have greatly enhanced our understanding of a wide range of phenomena from cellular processes (e.g., DNA replication and transcription) to viral oncogenesis.

The current chapter will focus upon the five known JCV early proteins and the contributions each makes to the oncogenic process (transformation) when expressed in cultured cells. Where appropriate, gaps in our understanding of JCV protein function will be supplanted with information obtained from the study of SV40 and BKV.

Keywords

Simian Virus Early Protein Human Polyomavirus Transcriptional Control Region Mouse Polyomavirus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Authors and Affiliations

  • Richard J. Frisque
    • 1
  • Catherine Hofstetter
    • 1
  • Shiva K. Tyagarajan
    • 1
  1. 1.Pennsylvania State UniversityUniversity ParkUSA

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