Polyomaviruses and Human Diseases pp 274-287

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 577) | Cite as

The Polyomavirus, JCV, and Its Involvement in Human Disease

  • Kamel Khalili
  • Jennifer Gordon
  • Martyn K. White

Abstract

The human neurotropic polyomavirus, JC virus (JCV), is the etiologic agent of progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease of the central nervous system that occurs mainly in immunosuppressed patients. JCV has also been found to be associated with human tumors of the brain and other organs. In this chapter, we describe JC virus and its role in human diseases.

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© Eurekah.com and Springer Science+Business Media 2006

Authors and Affiliations

  • Kamel Khalili
    • 1
  • Jennifer Gordon
    • 1
  • Martyn K. White
    • 1
  1. 1.Center for Neurovirology and Cancer BiologyTemple UniversityPhiladelphiaUSA

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