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Hypoxia-Inducible Factor (HIF)-1α and Endothelin-1 Expression in the Rat Carotid Body during Intermittent Hypoxia

  • SIU-YIN LAM
  • GEORGE L. TIPOE
  • EMILY C. LIONG
  • MANLUNG FUNG
Part of the ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY book series (AEMB, volume 580)

Abstract

Physiological responses to hypoxia involve changes in gene expression that are mediated by the transcriptional activator HIF-1. HIF-1 is a heterodimeric transcription factor consisting of two subunits, HIF-1α and HIF-1β (Semenza, 2000; Wang et al., 1995). The expression of HIF-1α protein is closely regulated by oxygen tension in the cell, whereas HIF-1β expression is constitutive and independent of oxygen levels (Kallio et al., 1999; Semenza, 2000; Wang et al., 1995). It has been shown that HIF-1α plays a physiological role in chronic hypoxia (CH). HIF-1α serves as a key controller for the transcriptional regulation of the expression of a spectrum of oxygen-regulated genes, such as erythropoietin, vascular endothelial growth factor (VEGF) and VEGF receptors, for the cellular response to hypoxia in tissues including the carotid body (CB) (Fung, 2003; Glaus et al., 2004; Semenza, 2000; Tipoe and Fung, 2003).

Keywords

Tyrosine Hydroxylase Vascular Endothelial Growth Factor Receptor Carotid Body Intermittent Hypoxia Chronic Hypoxia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2006

Authors and Affiliations

  • SIU-YIN LAM
    • 1
  • GEORGE L. TIPOE
    • 2
  • EMILY C. LIONG
    • 2
  • MANLUNG FUNG
    • 1
  1. 1.Departments of Physiology, Faculty of MedicineThe University of Hong KongHong KongChina
  2. 2.Departments of Anatomy, Faculty of MedicineThe University of Hong KongHong KongChina

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