In Search of the Acute Oxygen Sensor
Detecting and reacting to acute perturbation in the partial pressure of atmospheric oxygen (pO2), particularly hypoxia, is a fundamental adaptive mechanism which is conserved throughout the animal kingdom. In mammals, a number of cellular systems respond, often co-operatively as oxygen availability becomes compromised, with the express aim of maximising oxygen uptake by the lungs and of optimising its delivery to the metabolically most active tissues. Thus, during hypoxia, ventilation rate and depth are increased to maximize air flow across the gaseous exchange surface, local lung perfusion rates become rapidly matched to local alveolar ventilation and systemic arteriolar dilatation ensures that tissue and cerebral blood flow become swiftly optimized.
KeywordsCarotid Body Glomus Cell Hypoxic Ventilatory Response Peptide Mass Mapping Gaseous Exchange Surface
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