DSD-1-Proteoglycan/Phosphacan and Receptor Protein Tyrosine Phosphatase-Beta Isoforms during Development and Regeneration of Neural Tissues

  • Andreas Faissner
  • Nicolas Heck
  • Alexandre Dobbertin
  • Jeremy Garwood
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 557)

Summary

Interactions between neurons and glial cells play important roles in regulating key events of development and regeneration of the CNS. Thus, migrating neurons are partly guided by radial glia to their target, and glial scaffolds direct the growth and directional choice of advancing axons, e.g., at the midline. In the adult, reactive astrocytes and myelin components play a pivotal role in the inhibition of regeneration. The past years have shown that astrocytic functions are mediated on the molecular level by extracellular matrix components, which include various glycoproteins and proteoglycans. One important, developmentally regulated chondroitin sulfate proteoglycan is DSD-1-PG/phosphacan, a glial derived proteoglycan which represents a splice variant of the receptor protein tyrosine phosphatase (RPTP)-beta (also known as PTP-zeta). Current evidence suggests that this proteoglycan influences axon growth in development and regeneration, displaying inhibitory or stimulatory effects dependent on the mode of presentation, and the neuronal lineage. These effects seem to be mediated by neuronal receptors of the Ig-CAM superfamily.

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References

  1. 1.
    Jacobson M. Developmental neurobiology. 3rd ed. New York and London: Plenum Press; 1991.Google Scholar
  2. 2.
    Brummendorf T, Rathjen FG. Axonal glycoproteins with immunoglobulin-and fibronectin type III-related domains in vertebrates: Structural features, binding activities, and signal transduction. J Neurochem 1993; 61(4):1207–1219.PubMedGoogle Scholar
  3. 3.
    Brummendorf T, Rathjen FG. Structure/function relationships of axon-associated adhesion receptors of the immunoglobulin superfamily. Curr Opin Neurobiol 1996; 6(5):584–593.PubMedGoogle Scholar
  4. 4.
    Takeichi M. Morphogenetic roles of classic cadherins. Curr Opin Cell Biol 1995; 7(5):619–627.PubMedGoogle Scholar
  5. 5.
    Uemura T. The cadherin superfamily at the synapse: More members, more missions. Cell 1998; 93(7):1095–1098.PubMedGoogle Scholar
  6. 6.
    Tessier-Lavigne M. Eph receptor tyrosine kinases, axon repulsion, and the development of topographic maps. Cell 1995; 82(3):345–348.PubMedGoogle Scholar
  7. 7.
    Drescher U, Bonhoeffer F, Muller BK. The Eph family in retinal axon guidance. Curr Opin Neurobiol 1997; 7(1):75–80.PubMedGoogle Scholar
  8. 8.
    Klein R. Bidirectional signals establish boundaries. Curr Biol 1999; 9(18):R691–694.PubMedGoogle Scholar
  9. 9.
    Xu Q, Mellitzer G, Robinson V et al. In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins. Nature 1999; 399(6733):267–271.PubMedGoogle Scholar
  10. 10.
    Garwood J, Heck N, Rigato F et al. The extracellular matrix in neural development, plasticity and regeneration. In: Walz W, ed. The neuronal microenvironment. New Jersey, USA: Humana Press; 2002:109–158.Google Scholar
  11. 11.
    Sanes JR. Extracellular matrix molecules that influence neural development. Annu Rev Neurosci 1989; 12:491–516.PubMedGoogle Scholar
  12. 12.
    Hynes RO, Lander AD. Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons. Cell 1992; 68(2):303–322.PubMedGoogle Scholar
  13. 13.
    Faissner A, Steindler D. Boundaries and inhibitory molecules in developing neural tissues. Glia 1995; 13(4):233–254.PubMedGoogle Scholar
  14. 14.
    Faissner A. The tenascin gene family in axon growth and guidance. Cell Tissue Res 1997; 290(2):331–341.PubMedGoogle Scholar
  15. 15.
    Miao HQ, Ishai-Michaeli R, Atzmon R et al. Sulfate moieties in the subendothelial extracellular matrix are involved in basic fibroblast growth factor sequestration, dimerization, and stimulation of cell proliferation. J Biol Chem 1996; 271(9):4879–4886.PubMedGoogle Scholar
  16. 16.
    Hynes RO. Integrins: Versatility, modulation, and signaling in cell adhesion. Cell 1992; 69(1):11–25.PubMedGoogle Scholar
  17. 17.
    Dedhar S, Hannigan GE. Integrin cytoplasmic interactions and bidirectional transmembrane signalling. Curr Opin Cell Biol 1996; 8(5):657–669.PubMedGoogle Scholar
  18. 18.
    Fields RD, Itoh K. Neural cell adhesion molecules in activity-dependent development and synaptic plasticity. Trends Neurosci 1996; 19(11):473–480.PubMedGoogle Scholar
  19. 19.
    Lander AD. Proteoglycans: Master regulators of molecular encounter? Matrix Biol 1998; 17(7):465–472.PubMedGoogle Scholar
  20. 20.
    Kiang WL, Margolis RU, Margolis RK. Fractionation and properties of a chondroitin sulfate proteoglycan and the soluble glycoproteins of brain. J Biol Chem 1981; 256(20):10529–10537.PubMedGoogle Scholar
  21. 21.
    Herndon ME, Lander AD. A diverse set of developmentally regulated proteoglycans is expressed in the rat central nervous system. Neuron 1990; 4(6):949–961.PubMedGoogle Scholar
  22. 22.
    Klinger MM, Margolis RU, Margolis RK. Isolation and characterization of the heparan sulfate proteoglycans of brain. Use of affinity chromatography on lipoprotein lipase-agarose. J Biol Chem 1985; 260(7):4082–4090.PubMedGoogle Scholar
  23. 23.
    Tessier-Lavigne M, Goodman CS. The molecular biology of axon guidance. Science 1996; 274(5290):1123–1133.PubMedGoogle Scholar
  24. 24.
    Luo Y, Raible D, Raper JA. Collapsin: A protein in brain that induces the collapse and paralysis of neuronal growth cones. Cell 1993; 75(2):217–227.PubMedGoogle Scholar
  25. 25.
    Goodman CS. Mechanisms and molecules that control growth cone guidance. Annu Rev Neurosci 1996; 19:341–377.PubMedGoogle Scholar
  26. 26.
    Luo Y, Raper JA. Inhibitory factors controlling growth cone motility and guidance. Curr Opin Neurobiol 1994; 4(5):648–654.PubMedGoogle Scholar
  27. 27.
    Fournier AE, Strittmatter SM. Repulsive factors and axon regeneration in the CNS. Curr Opin Neurobiol 2001; 11(1):89–94.PubMedGoogle Scholar
  28. 28.
    Schwab ME, Kapfhammer JP, Bandtlow CE. Inhibitors of neurite growth. Annu Rev Neurosci 1993; 16:565–595.PubMedGoogle Scholar
  29. 29.
    Huber AB, Schwab ME. Nogo-A, a potent inhibitor of neurite outgrowth and regeneration. Biol Chem 2000; 381(5–6):407–419.PubMedGoogle Scholar
  30. 30.
    Dou CL, Levine JM. Inhibition of neurite growth by the NG2 chondroitin sulfate proteoglycan. J. Neurosci 1994; 14(12):7616–7628.Google Scholar
  31. 31.
    Margolis RK, Rauch U, Maurel P et al. Neurocan and phosphacan: Two major nervous tissue-specific chondroitin sulfate proteoglycans. Perspect Dev Neurobiol 1996; 3(4):273–290.PubMedGoogle Scholar
  32. 32.
    Zaremba S, Guimaraes A, Kalb RG et al. Characterization of an activity-dependent, neuronal surface proteoglycan identified with monoclonal antibody Cat-301. Neuron 1989; 2(3):1207–1219.PubMedGoogle Scholar
  33. 33.
    Hockfield S, Tootell RB, Zaremba S. Molecular differences among neurons reveal an organization of human visual cortex. Proc Natl Acad Sci USA 1990; 87(8):3027–3031.PubMedGoogle Scholar
  34. 34.
    Kalb RG, Hockfield S. Induction of a neuronal proteoglycan by the NMDA receptor in the developing spinal cord. Science 1990; 250(4978):294–296.PubMedGoogle Scholar
  35. 35.
    Snow DM, Steindler DA, Silver J. Molecular and cellular characterization of the glial roof plate of the spinal cord and optic tectum: A possible role for a proteoglycan in the development of an axon barrier. Dev Biol 1990; 138(2):359–376.PubMedGoogle Scholar
  36. 36.
    Katoh-Semba R, Matsuda M, Kato K et al. Chondroitin sulphate proteoglycans in the rat brain: Candidates for axon barriers of sensory neurons and the possible modification by laminin of their actions. Eur J Neurosci 1995; 7(4):613–621.PubMedGoogle Scholar
  37. 37.
    Landolt RM, Vaughan L, Winterhalter KH et al. Versican is selectively expressed in embryonic tissues that act as barriers to neural crest cell migration and axon outgrowth. Development 1995; 121(8):2303–2312.PubMedGoogle Scholar
  38. 38.
    Oakley RA, Tosney KW. Peanut agglutinin and chondroitin-6-sulfate are molecular markers for tissues that act as barriers to axon advance in the avian embryo. Dev Biol 1991; 147(1):187–206.PubMedGoogle Scholar
  39. 39.
    Gonzalez ML, Silver J. Axon-glia interactions regulate ECM patterning in the postnatal rat olfactory bulb. J Neurosci 1994; 14(10):6121–6131.PubMedGoogle Scholar
  40. 40.
    Gonzalez Mde L, Malemud CJ, Silver J. Role of astroglial extracellular matrix in the formation of rat olfactory bulb glomeruli. Exp Neurol 1993; 123(1):91–105.PubMedGoogle Scholar
  41. 41.
    Steindler DA. Glial boundaries in the developing nervous system. Annu Rev Neurosci 1993; 16:445–470.PubMedGoogle Scholar
  42. 42.
    Steindler DA, Settles D, Erickson HP et al. Tenascin knockout mice: Barrels, boundary molecules, and glial scars. J Neurosci 1995; 15(3 Pt 1):1971–1983.PubMedGoogle Scholar
  43. 43.
    Crandall JE, Misson JP, Butler D. The development of radial glia and radial dendrites during barrel formation in mouse somatosensory cortex. Brain Res Dev Brain Res 1990; 55(1):87–94.PubMedGoogle Scholar
  44. 44.
    Steindler DA, Cooper NG, Faissner A et al. Boundaries defined by adhesion molecules during development of the cerebral cortex: The J1/tenascin glycoprotein in the mouse somatosensory cortical barrel field. Dev Biol 1989; 131(1):243–260.PubMedGoogle Scholar
  45. 45.
    Fitch MT, Silver J. Glial cell extracellular matrix: boundaries for axon growth in development and regeneration. Cell Tissue Res 1997; 290(2):379–384.PubMedGoogle Scholar
  46. 46.
    Pindzola RR, Doller C, Silver J. Putative inhibitory extracellular matrix molecules at the dorsal root entry zone of the spinal cord during development and after root and sciatic nerve lesions. Dev Biol 1993; 156(1):34–48.PubMedGoogle Scholar
  47. 47.
    Levine JM. Increased expression of the NG2 chondroitin-sulfate proteoglycan after brain injury. J Neurosci 1994; 14(8):4716–4730.PubMedGoogle Scholar
  48. 48.
    McKeon RJ, Jurynec MJ, Buck CR. The chondroitin sulfate proteoglycans neurocan and phosphacan are expressed by reactive astrocytes in the chronic CNS glial scar. J Neurosci 1999; 19(24):10778–10788.PubMedGoogle Scholar
  49. 49.
    Haas CA, Rauch U, Thon N et al. Entorhinal cortex lesion in adult rats induces the expression of the neuronal chondroitin sulfate proteoglycan neurocan in reactive astrocytes. J Neurosci 1999; 19(22):9953–9963.PubMedGoogle Scholar
  50. 50.
    Asher RA, Morgenstern DA, Fidler PS et al. Neurocan is upregulated in injured brain and in cytokine-treated astrocytes. J Neurosci 2000; 20(7):2427–2438.PubMedGoogle Scholar
  51. 51.
    Stichel CC, Kappler J, Junghans U et al. Differential expression of the small chondroitin/dermatan sulfate proteoglycans decorin and biglycan after injury of the adult rat brain. Brain Res 1995; 704(2):263–274.PubMedGoogle Scholar
  52. 52.
    Asher RA, Morgenstern DA, Shearer MC et al. Versican is upregulated in CNS injury and is a product of oligodendrocyte lineage cells. J Neurosci 2002; 22(6):2225–2236.PubMedGoogle Scholar
  53. 53.
    Jaworski DM, Kelly GM, Hockfield S. Intracranial injury acutely induces the expression of the secreted isoform of the CNS-specific hyaluronan-binding protein BEHAB/brevican. Exp Neurol 1999; 157(2):327–337.PubMedGoogle Scholar
  54. 54.
    Thon N, Haas CA, Rauch U et al. The chondroitin sulphate proteoglycan brevican is upregulated by astrocytes after entorhinal cortex lesions in adult rats. Eur J Neurosci 2000; 12(7):2547–2558.PubMedGoogle Scholar
  55. 55.
    Bahr M, Bonhoeffer F. Perspectives on axonal regeneration in the mammalian CNS. Trends Neurosci 1994; 17(11):473–479.PubMedGoogle Scholar
  56. 56.
    Fawcett JW. Astrocytic and neuronal factors affecting axon regeneration in the damaged central nervous system. Cell Tissue Res 1997; 290(2):371–377.PubMedGoogle Scholar
  57. 57.
    Fawcett JW, Asher RA. The glial scar and central nervous system repair. Brain Res Bull 1999; 49(6):377–391.PubMedGoogle Scholar
  58. 58.
    Fawcett JW. Spinal cord repair: from experimental models to human application. Spinal Cord 1998; 36(12):811–817.PubMedGoogle Scholar
  59. 59.
    Brodkey JA, Laywell ED, O’Brien TF et al. Focal brain injury and upregulation of a developmentally regulated extracellular matrix protein. J Neurosurg 1995; 82(1):106–112.PubMedGoogle Scholar
  60. 60.
    Reier P. Gliosis following CNS injury: The anatomy of glial scars and their influences on axonal elongation. In: Federoff S, Vernadakis A, eds. Astrocytes. New York: Academic Press; 1986:263–324.Google Scholar
  61. 61.
    Landis DM. The early reactions of non-neuronal cells to brain injury. Annu Rev Neurosci 1994; 17:133–151.PubMedGoogle Scholar
  62. 62.
    Rudge JS, Silver J. Inhibition of neurite outgrowth on astroglial scars in vitro. J Neurosci 1990; 10(11):3594–3603.PubMedGoogle Scholar
  63. 63.
    Bähr M, Przyrembel C, Bastmeyer M. Astrocytes from adult rat optic nerves are nonpermissive for regenerating retinal ganglion cell axons. Exp Neurol 1995; 131:211–220.PubMedGoogle Scholar
  64. 64.
    Liuzzi FJ, Lasek RJ. Astrocytes block axonal regeneration in mammals by activating the physiological stop pathway. Science 1987; 237(4815):642–645.PubMedGoogle Scholar
  65. 65.
    Davies SJ, Field PM, Raisman G. Regeneration of cut adult axons fails even in the presence of continuous aligned glial pathways. Exp Neurol 1996; 142(2):203–216.PubMedGoogle Scholar
  66. 66.
    Gallo V, Bertolotto A, Levi G. The proteoglycan chondroitin sulfate is present in a subpopulation of cultured astrocytes and in their precursors. Dev Biol 1987; 123(1):282–285.PubMedGoogle Scholar
  67. 67.
    McKeon RJ, Schreiber RC, Rudge JS et al. Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes. J Neurosci 1991; 11(11):3398–3411.PubMedGoogle Scholar
  68. 68.
    McKeon RJ, Hoke A, Silver J. Injury-induced proteoglycans inhibit the potential for laminin-mediated axon growth on astrocytic scars. Exp Neurol 1995; 136(1):32–43.PubMedGoogle Scholar
  69. 69.
    Bovolenta P, Wandosell F, Nieto-Sampedro M. Neurite outgrowth inhibitors associated with glial cells and glial cell lines. Neuroreport 1993; 5(3):345–348.PubMedGoogle Scholar
  70. 70.
    Bovolenta P, Wandosell F, Nieto-Sampedro M. Characterization of a neurite outgrowth inhibitor expressed after CNS injury. Eur J Neurosci 1993; 5(5):454–465.PubMedGoogle Scholar
  71. 71.
    Snow DM, Lemmon V, Carrino DA et al. Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro. Exp Neurol 1990; 109(1):111–130.PubMedGoogle Scholar
  72. 72.
    Davies SJ, Fitch MT, Memberg SP et al. Regeneration of adult axons in white matter tracts of the central nervous system. Nature 1997; 390(6661):680–683.PubMedGoogle Scholar
  73. 73.
    Davies SJ, Goucher DR, Doller C et al. Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord. J Neurosci 1999; 19(14):5810–5822.PubMedGoogle Scholar
  74. 74.
    Zuo J, Ferguson TA, Hernandez YJ et al. Neuronal matrix metalloproteinase-2 degrades and inactivates a neurite-inhibiting chondroitin sulfate proteoglycan. J Neurosci 1998; 18(14):5203–5211.PubMedGoogle Scholar
  75. 75.
    Zuo J, Neubauer D, Dyess K et al. Degradation of chondroitin sulfate proteoglycan enhances the neurite-promoting potential of spinal cord tissue. Exp Neurol 1998; 154(2):654–662.PubMedGoogle Scholar
  76. 76.
    Yick LW, Wu W, So KF et al. Chondroitinase ABC promotes axonal regeneration of Clarke’s neurons after spinal cord injury. Neuroreport 2000; 11(5):1063–1067.PubMedGoogle Scholar
  77. 77.
    Moon LD, Brecknell JE, Franklin RJ et al. Robust regeneration of CNS axons through a track depleted of CNS glia. Exp Neurol 2000; 161(1):49–66.PubMedGoogle Scholar
  78. 78.
    Groves AK, Entwistle A, Jat PS et al. The characterization of astrocyte cell lines that display properties of glial scar tissue. Dev Biol 1993; 159(1):87–104.PubMedGoogle Scholar
  79. 79.
    Smith-Thomas LC, Fok-Seang J, Stevens J et al. An inhibitor of neurite outgrowth produced by astrocytes. J Cell Sci 1994; 107 (Pt 6):1687–1695.PubMedGoogle Scholar
  80. 80.
    Smith-Thoams LC, Stevens J, Fok-Seang J et al. Increased axon regeneration in astrocytes grown in the presence of proteoglycan synthesis inhibitors. J Cell Sci 1995; 108 (Pt 3):1307–1315.Google Scholar
  81. 81.
    Powell EM, Meiners S, DiProspero NA et al. Mechanisms of astrocyte-directed neurite guidance. Cell Tissue Res 1997; 290(2):385–393.PubMedGoogle Scholar
  82. 82.
    Meiners S, Powell EM, Geller HM. A distinct subset of tenascin/CS-6-PG-rich astrocytes restricts neuronal growth in vitro. J Neurosci 1995; 15(12):8096–8108.PubMedGoogle Scholar
  83. 83.
    Fidler PS, Schuette K, Asher RA et al. Comparing astrocytic cell lines that are inhibitory or permissive for axon growth: The major axon-inhibitory proteoglycan is NG2. J Neurosci 1999; 19(20):8778–8788.PubMedGoogle Scholar
  84. 84.
    Levine JM, Stallcup WB. Plasticity of developing cerebellar cells in vitro studied with antibodies against the NG2 antigen. J Neurosci 1987; 7(9):2721–2731.PubMedGoogle Scholar
  85. 85.
    Levine JM, Reynolds R, Fawcett JW. The oligodendrocyte precursor cell in health and disease. Trends Neurosci 2001; 24(1):39–47.PubMedGoogle Scholar
  86. 86.
    Dou CL, Levine JM. Differential effects of glycosaminoglycans on neurite growth on laminin and L1 substrates. J Neurosci 1995; 15(12):8053–8066.PubMedGoogle Scholar
  87. 87.
    Stallcup WB, Beasley L. Bipotential glial precursor cells of the optic nerve express the NG2 proteoglycan. J Neurosci 1987; 7(9):2737–2744.PubMedGoogle Scholar
  88. 88.
    Lander AD. Proteoglycans in the nervous system. Curr Opin Neurobiol 1993; 3(5):716–723.PubMedGoogle Scholar
  89. 89.
    Bandtlow CE, Zimmermann DR. Proteoglycans in the developing brain: new conceptual insights for old proteins. Physiol Rev 2000; 80(4):1267–1290.PubMedGoogle Scholar
  90. 90.
    Garwood J, Schnadelbach O, Clement A et al. DSD-1-proteoglycan is the mouse homolog of phosphacan and displays opposing effects on neurite outgrowth dependent on neuronal lineage. J Neurosci 1999; 19(10):3888–3899.PubMedGoogle Scholar
  91. 91.
    Maeda N, Noda M. Involvement of receptor-like protein tyrosine phosphatase zeta/RPTPbeta and its ligand pleiotrophin/heparin-binding growth-associated molecule (HB-GAM) in neuronal migration. J Cell Biol 1998; 142(1):203–216.PubMedGoogle Scholar
  92. 92.
    Harroch S, Palmeri M, Rosenbluth J et al. No obvious abnormality in mice deficient in receptor protein tyrosine phosphatase beta. Mol Cell Biol 2000; 20(20):7706–7715.PubMedGoogle Scholar
  93. 93.
    Faissner A, Clement A, Lochter A et al. Isolation of a neural chondroitin sulfate proteoglycan with neurite outgrowth promoting properties. J Cell Biol 1994; 126(3):783–799.PubMedGoogle Scholar
  94. 94.
    Hoffman S, Edelman GM. A proteoglycan with HNK-1 antigenic determinants is a neuron-associated ligand for cytotactin. Proc Natl Acad Sci USA 1987; 84(8):2523–2527.PubMedGoogle Scholar
  95. 95.
    Hoffman S, Crossin KL, Edelman GM. Molecular forms, binding functions, and developmental expression patterns of cytotactin and cytotactin-binding proteoglycan, an interactive pair of extracellular matrix molecules. J Cell Biol 1988; 106(2):519–532.PubMedGoogle Scholar
  96. 96.
    Clement AM, Nadanaka S, Masayama K et al. The DSD-1 carbohydrate epitope depends on sulfation, correlates with chondroitin sulfate D motifs, and is sufficient to promote neurite outgrowth. J Biol Chem 1998; 273(43):28444–28453.PubMedGoogle Scholar
  97. 97.
    Maurel P, Rauch U, Flad M et al. Phosphacan, a chondroitin sulfate proteoglycan of brain that interacts with neurons and neural cell-adhesion molecules, is an extracellular variant of a receptor-type protein tyrosine phosphatase. Proc Natl Acad Sci USA 1994; 91(7):2512–2516.PubMedGoogle Scholar
  98. 98.
    Krueger NX, Saito H. A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases. Proc Natl Acad Sci USA 1992; 89(16):7417–7421.PubMedGoogle Scholar
  99. 99.
    Barnea G, Grumet M, Milev P et al. Receptor tyrosine phosphatase beta is expressed in the form of proteoglycan and binds to the extracellular matrix protein tenascin. J Biol Chem 1994; 269(20):14349–14352.PubMedGoogle Scholar
  100. 100.
    Canoll PD, Barnea G, Levy JB et al. The expression of a novel receptor-type tyrosine phosphatase suggests a role in morphogenesis and plasticity of the nervous system. Brain Res Dev Brain Res 1993; 75(2):293–298.PubMedGoogle Scholar
  101. 101.
    Canoll PD, Petanceska S, Schlessinger J et al. Three forms of RPTP-beta are differentially expressed during gliogenesis in the developing rat brain and during glial cell differentiation in culture. J Neurosci Res 1996; 44(3):199–215.PubMedGoogle Scholar
  102. 102.
    Meyer-Puttlitz B, Milev P, Junker E et al. Chondroitin sulfate and chondroitin/keratan sulfate proteoglycans of nervous tissue: Developmental changes of neurocan and phosphacan. J Neurochem 1995; 65(5):2327–2337.PubMedGoogle Scholar
  103. 103.
    Nagata S, Saito R, Yamada Y et al. Multiple variants of receptor-type protein tyrosine phosphatase beta are expressed in the central nervous system of Xenopus. Gene 2001; 262(1–2):81–88.PubMedGoogle Scholar
  104. 104.
    Maeda N, Noda M. 6B4 proteoglycan/phosphacan is a repulsive substratum but promotes morphological differentiation of cortical neurons. Development 1996; 122(2):647–658.PubMedGoogle Scholar
  105. 105.
    Meyer-Puttlitz B, Junker E, Margolis RU et al. Chondroitin sulfate proteoglycans in the developing central nervous system. II. Immunocytochemical localization of neurocan and phosphacan. J Comp Neurol 1996; 366(1):44–54.PubMedGoogle Scholar
  106. 106.
    Garwood J, Rigato F, Heck N et al. Tenascin glycoproteins and the complementary ligand DSD-1-PG/phosphacan — structuring the neural extracellular matrix during development and repair. Restor Neurol Neurosci 2001; 19(1,2):51–64.PubMedGoogle Scholar
  107. 107.
    Faissner A. Monoclonal antibody identifies a proteoglycan expressed by a subclass of glial cells. Soc Neurosci Abstr 1988; 14:920.Google Scholar
  108. 108.
    Schnadelbach O, Mandl C, Faissner A. Expression of DSD-1-PG in primary neural and glial-derived cell line cultures, upregulation by TGF-beta, and implications for cell-substrate interactions of the glial cell line Oli-neu. Glia 1998; 23(2):99–119.PubMedGoogle Scholar
  109. 109.
    Sakurai T, Friedlander DR, Grumet M. Expression of polypeptide variants of receptor-type protein tyrosine phosphatase beta: The secreted form, phosphacan, increases dramatically during embryonic development and modulates glial cell behavior in vitro. J Neurosci Res 1996; 43(6):694–706.PubMedGoogle Scholar
  110. 110.
    Engel M, Maurel P, Margolis RU et al. Chondroitin sulfate proteoglycans in the developing central nervous system. I. cellular sites of synthesis of neurocan and phosphacan. J Comp Neurol 1996; 366(1):34–43.PubMedGoogle Scholar
  111. 111.
    Rauch U, Gao P, Janetzko A et al. Isolation and characterization of developmentally regulated chondroitin sulfate and chondroitin/keratan sulfate proteoglycans of brain identified with monoclonal antibodies. J Biol Chem 1991; 266(22):14785–14801.PubMedGoogle Scholar
  112. 112.
    Heyman I, Faissner A, Lumsden A. Cell and matrix specialisations of rhombomere boundaries. Dev Dyn 1995; 204(3):301–315.PubMedGoogle Scholar
  113. 113.
    Wintergerst ES, Faissner A, Celio MR. The proteoglycan DSD-1-PG occurs in perineuronal nets around parvalbumin-immunoreactive interneurons of the rat cerebral cortex. Int J Dev Neurosci 1996; 14(3):249–255.PubMedGoogle Scholar
  114. 114.
    Maleski M, Hockfield S. Glial cells assemble hyaluronan-based pericellular matrices in vitro. Glia 1997; 20(3):193–202.PubMedGoogle Scholar
  115. 115.
    Rauch U. Modeling an extracellular environment for axonal pathfinding and fasciculation in the central nervous system. Cell Tissue Res 1997; 290(2):349–356.PubMedGoogle Scholar
  116. 116.
    Celio MR, Blumcke I. Perineuronal nets—a specialized form of extracellular matrix in the adult nervous system. Brain Res Brain Res Rev 1994; 19(1):128–145.PubMedGoogle Scholar
  117. 117.
    Gates MA, Thomas LB, Howard EM et al. Cell and molecular analysis of the developing and adult mouse subventricular zone of the cerebral hemispheres. J Comp Neurol 1995; 361(2):249–266.PubMedGoogle Scholar
  118. 118.
    Goldman SA, Luskin MB. Strategies utilized by migrating neurons of the postnatal vertebrate forebrain. Trends Neurosci 1998; 21(3):107–114.PubMedGoogle Scholar
  119. 119.
    Thomas LB, Gates MA, Steindler DA. Young neurons from the adult subependymal zone proliferate and migrate along an astrocyte, extracellular matrix-rich pathway. Glia 1996; 17(1):1–14.PubMedGoogle Scholar
  120. 120.
    Shintani T, Watanabe E, Maeda N et al. Neurons as well as astrocytes express proteoglycan-type protein tyrosine phosphatase zeta/RPTPbeta: Analysis of mice in which the PTPzeta/RPTPbeta gene was replaced with the LacZ gene. Neurosci Lett 1998; 247(2–3):135–138.PubMedGoogle Scholar
  121. 121.
    Maeda N, Matsui F, Oohira A. A chondroitin sulfate proteoglycan that is developmentally regulated in the cerebellar mossy fiber system. Dev Biol 1992; 151(2):564–574.PubMedGoogle Scholar
  122. 122.
    Haunso A, Celio MR, Margolis RK et al. Phosphacan immunoreactivity is associated with perineuronal nets around parvalbumin-expressing neurones. Brain Res 1999; 834(1–2):219–222.PubMedGoogle Scholar
  123. 123.
    Snyder SE, Li J, Schauwecker PE et al. Comparison of RPTP zeta/beta, phosphacan, and trkB mRNA expression in the developing and adult rat nervous system and induction of RPTP zeta/beta and phosphacan mRNA following brain injury. Brain Res Mol Brain Res 1996; 40(1):79–96.PubMedGoogle Scholar
  124. 124.
    Lips K, Stichel CC, Muller HW. Restricted appearance of tenascin and chondroitin sulphate proteoglycans after transection and sprouting of adult rat postcommissural fornix. J Neurocytol 1995; 24(6):449–464.PubMedGoogle Scholar
  125. 125.
    Laywell ED, Dorries U, Bartsch U et al. Enhanced expression of the developmentally regulated extracellular matrix molecule tenascin following adult brain injury. Proc Natl Acad Sci USA 1992; 89(7):2634–2638.PubMedGoogle Scholar
  126. 126.
    Barker RA, Dunnett SB, Faissner A et al. The time course of loss of dopaminergic neurons and the gliotic reaction surrounding grafts of embryonic mesencephalon to the striatum. Exp Neurol 1996; 141(1):79–93.PubMedGoogle Scholar
  127. 127.
    Deller T, Haas CA, Frotscher M. Reorganization of the rat fascia dentata after a unilateral entorhinal cortex lesion. Role of the extracellular matrix. Ann NY Acad Sci 2000; 911:207–220.PubMedGoogle Scholar
  128. 128.
    Deller T, Haas CA, Naumann T et al. Up-regulation of astrocyte-derived tenascin-C correlates with neurite outgrowth in the rat dentate gyrus after unilateral entorhinal cortex lesion. Neuroscience 1997; 81(3):829–846.PubMedGoogle Scholar
  129. 129.
    Rauch U, Karthikeyan L, Maurel P et al. Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulfate proteoglycan of brain. J Biol Chem 1992; 267(27):19536–19547.PubMedGoogle Scholar
  130. 130.
    Oohira A, Matsui F, Katoh-Semba R. Inhibitory effects of brain chondroitin sulfate proteoglycans on neurite outgrowth from PC12D cells. J Neurosci 1991; 11(3):822–827.PubMedGoogle Scholar
  131. 131.
    Milev P, Friedlander DR, Sakurai T et al. Interactions of the chondroitin sulfate proteoglycan phosphacan, the extracellular domain of a receptor-type protein tyrosine phosphatase, with neurons, glia, and neural cell adhesion molecules. J Cell Biol 1994; 127(6 Pt 1):1703–1715.PubMedGoogle Scholar
  132. 132.
    Friedlander DR, Milev P, Karthikeyan L et al. The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth. J Cell Biol 1994; 125(3):669–680.PubMedGoogle Scholar
  133. 133.
    Brittis PA, Canning DR, Silver J. Chondroitin sulfate as a regulator of neuronal patterning in the retina. Science 1992; 255(5045):733–736.PubMedGoogle Scholar
  134. 134.
    Fichard A, Verna JM, Olivares J et al. Involvement of a chondroitin sulfate proteoglycan in the avoidance of chick epidermis by dorsal root ganglia fibers: a study using beta-D-xyloside. Dev Biol 1991; 148(1):1–9.PubMedGoogle Scholar
  135. 135.
    Grumet M, Flaccus A, Margolis RU. Functional characterization of chondroitin sulfate proteoglycans of brain: interactions with neurons and neural cell adhesion molecules. J Cell Biol 1993; 120(3):815–824.PubMedGoogle Scholar
  136. 136.
    Miller B, Sheppard AM, Pearlman AL. Developmental expression of keratan sulfate-like immunoreactivity distinguishes thalamic nuclei and cortical domains [published erratum appears in J Comp Neurol 1997 Sep 1;385(3):490–1]. J Comp Neurol 1997; 380(4):533–552.PubMedGoogle Scholar
  137. 137.
    Cole GJ, McCabe CF. Identification of a developmentally regulated keratan sulfate proteoglycan that inhibits cell adhesion and neurite outgrowth. Neuron 1991; 7(6):1007–1018.PubMedGoogle Scholar
  138. 138.
    Carbonetto S, Gruver MM, Turner DC. Nerve fiber growth in culture on fibronectin, collagen, and glycosaminoglycan substrates. J Neurosci 1983; 3(11):2324–2335.PubMedGoogle Scholar
  139. 139.
    Verna JM. In vitro analysis of interactions between sensory neurons and skin: Evidence for selective innervation of dermis and epidermis. J Embryol Exp Morphol 1985; 86:53–70.PubMedGoogle Scholar
  140. 140.
    Muir D, Engvall E, Varon S et al. Schwannoma cell-derived inhibitor of the neurite-promoting activity of laminin. J Cell Biol 1989; 109(5):2353–2362.PubMedGoogle Scholar
  141. 141.
    O’Brien TF, Faissner A, Schachner M et al. Afferent-boundary interactions in the developing neostriatal mosaic. Brain Res Dev Brain Res 1992; 65(2):259–267.PubMedGoogle Scholar
  142. 142.
    Crossin KL, Hoffman S, Tan SS et al. Cytotactin and its proteoglycan ligand mark structural and functional boundaries in somatosensory cortex of the early postnatal mouse. Dev Biol 1989; 136(2):381–392.PubMedGoogle Scholar
  143. 143.
    Inatani M, Honjo M, Otori Y et al. Inhibitory effects of neurocan and phosphacan on neurite outgrowth from retinal ganglion cells in culture. Invest Ophthalmol Vis Sci 2001; 42(8):1930–1938.PubMedGoogle Scholar
  144. 144.
    Chung KY, Taylor JS, Shum DK et al. Axon routing at the optic chiasm after enzymatic removal of chondroitin sulfate in mouse embryos. Development 2000; 127(12):2673–2683.PubMedGoogle Scholar
  145. 145.
    Moon L, Asher R, Rhodes K et al. Regeneration of CNS axons back to their target following treatment of adult rat brain with chondroitinase ABC. Nat Neurosci 2001; 4:465–466.PubMedGoogle Scholar
  146. 146.
    Emerling DE, Lander AD. Inhibitors and promoters of thalamic neuron adhesion and outgrowth in embryonic neocortex: functional association with chondroitin sulfate. Neuron 1996; 17(6):1089–1100.PubMedGoogle Scholar
  147. 147.
    Sheppard AM, Hamilton SK, Pearlman AL. Changes in the distribution of extracellular matrix components accompany early morphogenetic events of mammalian cortical development. J Neurosci 1991; 11(12):3928–3942.PubMedGoogle Scholar
  148. 148.
    Bicknese AR, Sheppard AM, O’Leary DD et al. Thalamocortical axons extend along a chondroitin sulfate proteoglycan-enriched pathway coincident with the neocortical subplate and distinct from the efferent path. J Neurosci 1994; 14(6):3500–3510.PubMedGoogle Scholar
  149. 149.
    Fukuda T, Kawano H, Ohyama K et al. Immunohistochemical localization of neurocan and L1 in the formation of thalamocortical pathway of developing rats. J Comp Neurol 1997; 382(2):141–152.PubMedGoogle Scholar
  150. 150.
    Ring C, Lemmon V, Halfter W. Two chondroitin sulfate proteoglycans differentially expressed in the developing chick visual system. Dev Biol 1995; 168(1):11–27.PubMedGoogle Scholar
  151. 151.
    McAdams BD, McLoon SC. Expression of chondroitin sulfate and keratan sulfate proteoglycans in the path of growing retinal axons in the developing chick. J Comp Neurol 1995; 352(4):594–606.PubMedGoogle Scholar
  152. 152.
    Streit A, Nolte C, Rasony T et al. Interaction of astrochondrin with extracellular matrix components and its involvement in astrocyte process formation and cerebellar granule cell migration. J Cell Biol 1993; 120(3):799–814.PubMedGoogle Scholar
  153. 153.
    Iijima N, Oohira A, Mori T et al. Core protein of chondroitin sulfate proteoglycan promotes neurite outgrowth from cultured neocortical neurons. J Neurochem 1991; 56(2):706–708.PubMedGoogle Scholar
  154. 154.
    Oohira A, Matsui F, Matsuda M et al. Occurrence of three distinct molecular species of chondroitin sulfate proteoglycan in the developing rat brain. J Biol Chem 1988; 263(21):10240–10246.PubMedGoogle Scholar
  155. 155.
    Sakurai T, Lustig M, Nativ M et al. Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta. J Cell Biol 1997; 136(4):907–918.PubMedGoogle Scholar
  156. 156.
    Peles E, Nativ M, Campbell PL et al. The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin. Cell 1995; 82(2):251–260.PubMedGoogle Scholar
  157. 157.
    Peles E, Nativ M, Lustig M et al. Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions. Embo J 1997; 16(5):978–988.PubMedGoogle Scholar
  158. 158.
    Streit A, Yuen CT, Loveless RW et al. The Le(x) carbohydrate sequence is recognized by antibody to L5, a functional antigen in early neural development. J Neurochem 1996; 66(2):834–844.PubMedGoogle Scholar
  159. 159.
    Damon DH, D’Amore PA, Wagner JA. Sulfated glycosaminoglycans modify growth factor-induced neurite outgrowth in PC12 cells. J Cell Physiol 1988; 135(2):293–300.PubMedGoogle Scholar
  160. 160.
    Hantaz-Ambroise D, Vigny M, Koenig J. Heparan sulfate proteoglycan and laminin mediate two different types of neurite outgrowth. J Neurosci 1987; 7(8):2293–2304.PubMedGoogle Scholar
  161. 161.
    Fernaud-Espinosa I, Nieto-Sampedro M, Bovolenta P. Differential effects of glycosaminoglycans on neurite outgrowth from hippocampal and thalamic neurones. J Cell Sci 1994; 107(Pt 6):1437–1448.PubMedGoogle Scholar
  162. 162.
    Lafont F, Prochiantz A, Valenza C et al. Defined glycosaminoglycan motifs have opposite effects on neuronal polarity in vitro. Dev Biol 1994; 165(2):453–468.PubMedGoogle Scholar
  163. 163.
    Lafont F, Rouget M, Triller A et al. In vitro control of neuronal polarity by glycosaminoglycans. Development 1992; 114(1):17–29.PubMedGoogle Scholar
  164. 164.
    Nadanaka S, Clement A, Masayama K et al. Characteristic hexasaccharide sequences in octasaccharides derived from shark cartilage chondroitin sulfate D with a neurite outgrowth promoting activity. J Biol Chem 1998; 273(6):3296–3307.PubMedGoogle Scholar
  165. 165.
    Clement AM, Sugahara K, Faissner A. Chondroitin sulfate E promotes neurite outgrowth of rat embryonic day 18 hippocampal neurons. Neurosci Lett 1999; 269(3):125–128.PubMedGoogle Scholar
  166. 166.
    Faissner A, Kruse J. J1/tenascin is a repulsive substrate for central nervous system neurons. Neuron 1990; 5(5):627–637.PubMedGoogle Scholar
  167. 167.
    Gotz B, Scholze A, Clement A et al. Tenascin-C contains distinct adhesive, anti-adhesive, and neurite outgrowth promoting sites for neurons. J Cell Biol 1996; 132(4):681–699.PubMedGoogle Scholar
  168. 168.
    Lochter A, Vaughan L, Kaplony A et al. J1/tenascin in substrate-bound and soluble form displays contrary effects on neurite outgrowth. J Cell Biol 1991; 113(5):1159–1171.PubMedGoogle Scholar
  169. 169.
    Snow DM, Letourneau PC. Neurite outgrowth on a step gradient of chondroitin sulfate proteoglycan (CS-PG). J Neurobiol 1992; 23(3):322–336.PubMedGoogle Scholar
  170. 170.
    Walsh FS, Doherty P. Neural cell adhesion molecules of the immunoglobulin superfamily: role in axon growth and guidance. Annu Rev Cell Dev Biol 1997; 13:425–456.PubMedGoogle Scholar
  171. 171.
    Adamsky K, Schilling J, Garwood J et al. Glial tumor cell adhesion is mediated by binding of the FNIII domain of receptor protein tyrosine phosphatase beta (RPTPbeta) to tenascin C. Oncogene 2001; 20(5):609–618.PubMedGoogle Scholar
  172. 172.
    Kawachi H, Fujikawa A, Maeda N et al. Identification of GIT1/Cat-1 as a substrate molecule of protein tyrosine phosphatase zeta /beta by the yeast substrate-trapping system. Proc Natl Acad Sci USA 2001; 98(12):6593–6598.PubMedGoogle Scholar
  173. 173.
    Kawachi H, Tamura H, Watakabe I et al. Protein tyrosine phosphatase zeta/RPTPbeta interacts with PSD-95/SAP90 family. Brain Res Mol Brain Res 1999; 72(1):47–54. bin/cas/tree/store/bresm/cas_sub/browse/browse.cgi?year=1999&volume=1972&issue=1991&aid=72194.PubMedGoogle Scholar
  174. 174.
    Ranscht B. Sequence of contactin, a 130-kD glycoprotein concentrated in areas of interneuronal contact, defines a new member of the immunoglobulin supergene family in the nervous system. J Cell Biol 1988; 107(4):1561–1573.PubMedGoogle Scholar
  175. 175.
    Gennarini G, Cibelli G, Rougon G et al. The mouse neuronal cell surface protein F3: A phosphatidylinositol-anchored member of the immunoglobulin superfamily related to chicken contactin. J Cell Biol 1989; 109(2):775–788.PubMedGoogle Scholar
  176. 176.
    Gennarini G, Durbec P, Boned A et al. Transfected F3/F11 neuronal cell surface protein mediates intercellular adhesion and promotes neurite outgrowth. Neuron 1991; 6(4):595–606.PubMedGoogle Scholar
  177. 177.
    Milev P, Maurel P, Haring M et al. TAG-1/axonin-1 is a high-affinity ligand of neurocan, phosphacan/protein-tyrosine phosphatase-zeta/beta, and N-CAM. J Biol Chem 1996; 271(26):15716–15723.PubMedGoogle Scholar
  178. 178.
    Roberts C, Platt N, Streit A et al. The L5 epitope: An early marker for neural induction in the chick embryo and its involvement in inductive interactions. Development 1991; 112(4):959–970.PubMedGoogle Scholar
  179. 179.
    Streit A, Faissner A, Gehrig B et al. Isolation and biochemical characterization of a neural proteoglycan expressing the L5 carbohydrate epitope. J Neurochem 1990; 55(5):1494–1506.PubMedGoogle Scholar
  180. 180.
    Allendoerfer KL, Magnani JL, Patterson PH. FORSE-1, an antibody that labels regionally restricted subpopulations of progenitor cells in the embryonic central nervous system, recognizes the Le(x) carbohydrate on a proteoglycan and two glycolipid antigens. Mol Cell Neurosci 1995; 6(4):381–395.PubMedGoogle Scholar
  181. 181.
    Milev P, Meyer-Puttlitz B, Margolis RK et al. Complex-type asparagine-linked oligosaccharides on phosphacan and protein-tyrosine phosphatase-zeta/beta mediate their binding to neural cell adhesion molecules and tenascin. J Biol Chem 1995; 270(42):24650–24653.PubMedGoogle Scholar
  182. 182.
    Zeng L, D’Alessandri L, Kalousek MB et al. Protein tyrosine phosphatase alpha (PTPalpha) and contactin form a novel neuronal receptor complex linked to the intracellular tyrosine kinase fyn. J Cell Biol 1999; 147(4):707–714.PubMedGoogle Scholar
  183. 183.
    Rios JC, Melendez-Vasquez CV, Einheber S et al. Contactin-associated protein (Caspr) and contactin form a complex that is targeted to the paranodal junctions during myelination. J Neurosci 2000; 20(22):8354–8364.PubMedGoogle Scholar
  184. 184.
    Fujikawa A, Watanabe E, Sakaguchi G et al. Dopaminergic dysfunction in the mice lacking the receptor tyrosine phosphatase zeta/RPTP-beta gene. Soc Neurosci Abstr 2001; 31:539.514.Google Scholar
  185. 185.
    Ratcliffe CF, Qu Y, McCormick KA et al. A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase beta. Nat Neurosci 2000; 3(5):437–444.PubMedGoogle Scholar
  186. 186.
    Milev P, Chiba A, Haring M et al. High affinity binding and overlapping localization of neurocan and phosphacan/protein-tyrosine phosphatase-zeta/beta with tenascin-R, amphoterin, and the heparin-binding growth-associated molecule. J Biol Chem 1998; 273(12):6998–7005.PubMedGoogle Scholar
  187. 187.
    Joester A, Faissner A. Evidence for combinatorial variability of tenascin-C isoforms and developmental regulation in the mouse central nervous system. J Biol Chem 1999; 274(24):17144–17151.PubMedGoogle Scholar
  188. 188.
    Joester A, Faissner A. The structure and function of tenascins in the nervous system. Matrix Biol 2001; 20(1):13–22.PubMedGoogle Scholar
  189. 189.
    Milev P, Fischer D, Haring M et al. The fibrinogen-like globe of tenascin-C mediates its interactions with neurocan and phosphacan/protein-tyrosine phosphatase-zeta/beta. J Biol Chem 1997; 272(24):15501–15509.PubMedGoogle Scholar
  190. 190.
    Meng K, Rodriguez-Pena A, Dimitrov T et al. Pleiotrophin signals increased tyrosine phosphorylation of beta—catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta /zeta [In Process Citation]. Proc Natl Acad Sci USA 2000; 97(6):2603–2608.PubMedGoogle Scholar
  191. 191.
    Lemons ML, Howland DR, Anderson DK. Chondroitin sulfate proteoglycan immunoreactivity increases following spinal cord injury and transplantation. Exp Neurol 1999; 160(1):51–65.PubMedGoogle Scholar
  192. 192.
    Li J, Tullai JW, Yu WH et al. Regulated expression during development and following sciatic nerve injury of mRNAs encoding the receptor tyrosine phosphatase HPTPzeta/RPTPbeta. Brain Res Mol Brain Res 1998; 60(1):77–88.PubMedGoogle Scholar
  193. 193.
    Wu YP, Siao CJ, Lu W et al. The tissue plasminogen activator (tPA)/plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrate. J Cell Biol 2000; 148(6):1295–1304.PubMedGoogle Scholar
  194. 194.
    Kurazono S, Okamoto M, Sakiyama J et al. Expression of brain specific chondroitin sulfate proteoglycans, neurocan and phosphacan, in the developing and adult hippocampus of Ihara’s epileptic rats. Brain Res 2001; 898(1):36–48.PubMedGoogle Scholar
  195. 195.
    Laywell ED, Steindler DA. Boundaries and wounds, glia and glycoconjugates. Cellular and molecular analyses of developmental partitions and adult brain lesions. Ann NY Acad Sci 1991; 633:122–141.PubMedGoogle Scholar
  196. 196.
    Perry VH, Brown MC. Macrophages and nerve regeneration. Curr Opin Neurobiol 1992; 2(5):679–682.PubMedGoogle Scholar
  197. 197.
    Hu S, Martella A, Anderson WR et al. Role of cytokines in lipopolysaccharide-induced functional and structural abnormalities of astrocytes. Glia 1994; 10(3):227–234.PubMedGoogle Scholar
  198. 198.
    Campbell IL. Cytokine-mediated inflammation and signaling in the intact central nervous system. Prog Brain Res 2001; 132:481–498.PubMedGoogle Scholar
  199. 199.
    Merrill JE, Benveniste EN. Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci 1996; 19(8):331–338.PubMedGoogle Scholar
  200. 200.
    Schonherr E, Jarvelainen HT, Sandell LJ et al. Effects of platelet-derived growth factor and transforming growth factor-beta 1 on the synthesis of a large versican-like chondroitin sulfate proteoglycan by arterial smooth muscle cells. J Biol Chem 1991; 266(26):17640–17647.PubMedGoogle Scholar
  201. 201.
    Redini F, Daireaux M, Mauviel A et al. Characterization of proteoglycans synthesized by rabbit articular chondrocytes in response to transforming growth factor-beta (TGF-beta). Biochim Biophys Acta 1991; 1093(2–3):196–206.PubMedGoogle Scholar
  202. 202.
    Romaris M, Heredia A, Molist A et al. Differential effect of transforming growth factor beta on proteoglycan synthesis in human embryonic lung fibroblasts. Biochim Biophys Acta 1991; 1093(2–3):229–233.PubMedGoogle Scholar
  203. 203.
    Benton HP, Tyler JA. Inhibition of cartilage proteoglycan synthesis by interleukin I. Biochem Biophys Res Commun 1988; 154(1):421–428.PubMedGoogle Scholar
  204. 204.
    Jung M, Kramer E, Grzenkowski M et al. Lines of murine oligodendroglial precursor cells immortalized by an activated neu tyrosine kinase show distinct degrees of interaction with axons in vitro and in vivo. Eur J Neurosci 1995; 7(6):1245–1265.PubMedGoogle Scholar
  205. 205.
    Fok-Seang J, Mathews GA, ffrench-Constant C et al. Migration of oligodendrocyte precursors on astrocytes and meningeal cells. Dev Biol 1995; 171(1):1–15.PubMedGoogle Scholar
  206. 206.
    Flanders KC, Ren RF, Lippa CF. Transforming growth factor-betas in neurodegenerative disease. Prog Neurobiol 1998; 54(1):71–85.PubMedGoogle Scholar
  207. 207.
    Flanders KC, Ludecke G, Engels S et al. Localization and actions of transforming growth factor-beta s in the embryonic nervous system. Development 1991; 113(1):183–191.PubMedGoogle Scholar
  208. 208.
    Krieglstein K, Suter-Crazzolara C, Fischer WH et al. TGF-beta superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity. Embo J 1995; 14(4):736–742.PubMedGoogle Scholar
  209. 209.
    Krieglstein K, Rufer M, Suter-Crazzolara C et al. Neural functions of the transforming growth factors beta. Int J Dev Neurosci 1995; 13(3–4):301–315.PubMedGoogle Scholar
  210. 210.
    Unsicker K, Meier C, Krieglstein K et al. Expression, localization, and function of transforming growth factor-beta s in embryonic chick spinal cord, hindbrain, and dorsal root ganglia. J Neurobiol 1996; 29(2):262–276.PubMedGoogle Scholar
  211. 211.
    Rapraeger A. Transforming growth factor (type beta) promotes the addition of chondroitin sulfate chains to the cell surface proteoglycan (syndecan) of mouse mammary epithelia. J Cell Biol 1989; 109(5):2509–2518.PubMedGoogle Scholar
  212. 212.
    Lindholm D, Castren E, Kiefer R et al. Transforming growth factor-beta 1 in the rat brain: Increase after injury and inhibition of astrocyte proliferation. J Cell Biol 1992; 117(2):395–400.PubMedGoogle Scholar
  213. 213.
    Logan A, Berry M, Gonzalez AM et al. Effects of transforming growth factor beta 1 on scar production in the injured central nervous system of the rat. Eur J Neurosci 1994; 6(3):355–363.PubMedGoogle Scholar
  214. 214.
    Bronner-Fraser M. Neural crest cell formation and migration in the developing embryo. Faseb J 1994; 8(10):699–706.PubMedGoogle Scholar
  215. 215.
    Perris R, Johansson S. Inhibition of neural crest cell migration by aggregating chondroitin sulfate proteoglycans is mediated by their hyaluronan-binding region. Dev Biol 1990; 137(1):1–12.PubMedGoogle Scholar
  216. 216.
    Perris R, Perissinotto D, Pettway Z et al. Inhibitory effects of PG-H/aggrecan and PG-M/versican on avian neural crest cell migration. Faseb J 1996; 10(2):293–301.PubMedGoogle Scholar
  217. 217.
    Small RK, Riddle P, Noble M. Evidence for migration of oligodendrocyte—type-2 astrocyte progenitor cells into the developing rat optic nerve. Nature 1987; 328(6126):155–157.PubMedGoogle Scholar
  218. 218.
    Pringle NP, Richardson WD. A singularity of PDGF alpha-receptor expression in the dorsoventral axis of the neural tube may define the origin of the oligodendrocyte lineage. Development 1993; 117(2):525–533.PubMedGoogle Scholar
  219. 219.
    Wolswijk G, Riddle PN, Noble M. Coexistence of perinatal and adult forms of a glial progenitor cell during development of the rat optic nerve. Development 1990; 109(3):691–698.PubMedGoogle Scholar
  220. 220.
    Hardy RJ, Friedrich VL Jr. Oligodendrocyte progenitors are generated throughout the embryonic mouse brain, but differentiate in restricted foci. Development 1996; 122(7):2059–2069.PubMedGoogle Scholar
  221. 221.
    Milner R, Edwards G, Streuli C et al. A role in migration for the alpha V beta 1 integrin expressed on oligodendrocyte precursors. J Neurosci 1996; 16(22):7240–7252.PubMedGoogle Scholar
  222. 222.
    Wang C, Rougon G, Kiss JZ. Requirement of polysialic acid for the migration of the O-2A glial progenitor cell from neurohypophyseal explants. J Neurosci 1994; 14(7):4446–4457.PubMedGoogle Scholar
  223. 223.
    Wang C, Pralong WF, Schulz MF et al. Functional N-methyl-D-aspartate receptors in O-2A glial precursor cells: A critical role in regulating polysialic acid-neural cell adhesion molecule expression and cell migration. J Cell Biol 1996; 135(6 Pt 1):1565–1581.PubMedGoogle Scholar
  224. 224.
    Milner R, Anderson HJ, Rippon RF et al. Contrasting effects of mitogenic growth factors on oligodendrocyte precursor cell migration. Glia 1997; 19(1):85–90.PubMedGoogle Scholar
  225. 225.
    McKinnon RD, Piras G, Ida JA Jr et al. A role for TGF-beta in oligodendrocyte differentiation. J Cell Biol 1993; 121(6):1397–1407.PubMedGoogle Scholar
  226. 226.
    Frost E, Kiernan BW, Faissner A et al. Regulation of oligodendrocyte precursor migration by extracellular matrix: evidence for substrate-specific inhibition of migration by tenascin-C. Dev Neurosci 1996; 18(4):266–273.PubMedGoogle Scholar
  227. 227.
    Luckenbill-Edds L. Laminin and the mechanism of neuronal outgrowth. Brain Res Brain Res Rev 1997; 23(1–2):1–27.PubMedGoogle Scholar
  228. 228.
    Lee EC, Lotz MM, Steele GD Jr et al. The integrin alpha 6 beta 4 is a laminin receptor. J Cell Biol 1992; 117(3):671–678.PubMedGoogle Scholar
  229. 229.
    Delwel GO, Hogervorst F, Kuikman I et al. Expression and function of the cytoplasmic variants of the integrin alpha 6 subunit in transfected K562 cells. Activation-dependent adhesion and interaction with isoforms of laminin. J Biol Chem 1993; 268(34):25865–25875.PubMedGoogle Scholar
  230. 230.
    Muller U, Bossy B, Venstrom K et al. Integrin alpha 8 beta 1 promotes attachment, cell spreading, and neurite outgrowth on fibronectin. Mol Biol Cell 1995; 6(4):433–448.PubMedGoogle Scholar
  231. 231.
    Varnum-Finney B, Venstrom K, Muller U et al. The integrin receptor alpha 8 beta 1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-C. Neuron 1995; 14(6):1213–1222.PubMedGoogle Scholar
  232. 232.
    Yokosaki Y, Palmer EL, Prieto AL et al. The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin. J Biol Chem 1994; 269(43):26691–26696.PubMedGoogle Scholar
  233. 233.
    Bauvois B, Van Weyenbergh J, Rouillard D et al. TGF-beta 1-stimulated adhesion of human mononuclear phagocytes to fibronectin and laminin is abolished by IFN-gamma: Dependence on alpha 5 beta 1 and beta 2 integrins. Exp Cell Res 1996; 222(1):209–217.PubMedGoogle Scholar
  234. 234.
    Kumar NM, Sigurdson SL, Sheppard D et al. Differential modulation of integrin receptors and extracellular matrix laminin by transforming growth factor-beta 1 in rat alveolar epithelial cells. Exp Cell Res 1995; 221(2):385–394.PubMedGoogle Scholar
  235. 235.
    Paulus W, Sage EH, Jellinger K et al. Type VIII collagen in the normal and diseased human brain. Acta Histochem Suppl 1992; 42:195–199.PubMedGoogle Scholar
  236. 236.
    Iida J, Skubitz AP, Furcht LT et al. Coordinate role for cell surface chondroitin sulfate proteoglycan and alpha 4 beta 1 integrin in mediating melanoma cell adhesion to fibronectin. J Cell Biol 1992; 118(2):431–444.PubMedGoogle Scholar
  237. 237.
    Milner R, Ffrench-Constant C. A developmental analysis of oligodendroglial integrins in primary cells: changes in alpha v-associated beta subunits during differentiation. Development 1994; 120(12):3497–3506.PubMedGoogle Scholar
  238. 238.
    Palecek SP, Loftus JC, Ginsberg MH et al. Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness. Nature 1997; 385(6616):537–540.PubMedGoogle Scholar
  239. 239.
    Revest JM, Faivre-Sarrailh C, Maeda N et al. The interaction between F3 immunoglobulin domains and protein tyrosine phosphatases zeta/beta triggers bidirectional signalling between neurons and glial cells. Eur J Neurosci 1999; 11(4):1134–1147.PubMedGoogle Scholar
  240. 240.
    Snow DM, Brown EM, Letourneau PC. Growth cone behavior in the presence of soluble chondroitin sulfate proteoglycan (CSPG), compared to behavior on CSPG bound to laminin or fibronectin. Int J Dev Neurosci 1996; 14(3):331–349.PubMedGoogle Scholar
  241. 241.
    Dobbertin A, Rhodes KE, Garwood J et al. Regulation of RPTPbeta/phosphacan expression and glycosaminoglycan epitopes in injured brain and cytokine-treated glia. Mol Cell Neurosci 2003; 24(4):951–971.PubMedGoogle Scholar

Copyright information

© Eurekah.com and Kluwer Academic / Plenum Publishers 2006

Authors and Affiliations

  • Andreas Faissner
    • 1
  • Nicolas Heck
    • 2
  • Alexandre Dobbertin
    • 3
  • Jeremy Garwood
    • 4
  1. 1.Department of Cell Morphology and Molecular NeurobiologyRuhr-UniversityBochumGermany
  2. 2.Institute of Physiology and PathophysiologyUniversity of MainzMainzGermany
  3. 3.INSERM U686Centre Universitaire des Saints-PéresParisFrance
  4. 4.Centre de Neurochimie du CNRSStrasbourgFrance

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