Brain Repair pp 177-190 | Cite as

The Collagenous Wound Healing Scar in the Injured Central Nervous System Inhibits Axonal Regeneration

  • Susanne Hermanns
  • Nicole Klapka
  • Marcia Gasis
  • Hans Werner Müller
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 557)

Abstract

Following traumatic injuries of the central nervous system (CNS) a wound healing scar, resembling the molecular structure of a basement membrane and mainly composed of Collagen type IV and associated glycoproteins and proteoglycans, is formed. It is well known that CNS fibers poorly regenerate after traumatic injuries. In this article we summarize data showing that prevention of collagen scar formation enables severed axons in brain and spinal cord to regrow across the lesion site and to elongate in uninjured CNS tissue. We observed that regenerating fibers grow back to their former target where they develop chemical synapses, become remyelinated by resident oligodendrocytes and conduct action potentials.

Keywords

Connective Tissue Growth Factor Lesion Site Injured Spinal Cord Basement Membrane Lesion Core 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Eurekah.com and Kluwer Academic / Plenum Publishers 2006

Authors and Affiliations

  • Susanne Hermanns
    • 1
  • Nicole Klapka
    • 2
  • Marcia Gasis
    • 2
  • Hans Werner Müller
    • 2
  1. 1.NEURAXO BIOTEC GmbHDüsseldorfGermany
  2. 2.Molecular Neurobiology Laboratory Department of NeurologyHeinrich-Heine-UniversityDüsseldorfGermany

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