Sequence-Dependent Variability of B-DNA

An Update on Bending and Curvature
  • Victor B. Zhurkin
  • Michael Y. Tolstorukov
  • Fei Xu
  • Andrew V. Colasanti
  • Wilma K. Olson
Part of the Molecular Biology Intelligence Unit book series (MBIU)


DNA bending is universal in biology—both the storage and the retrieval of information encoded in the base-pair sequence require significant deformations, particularly bending, of the double helix. The A-tract curvature, which modulates these processes, has thus been a subject of long-standing interest. Here we describe the ongoing evolution of models developed to account for the sequence-dependent bending and curvature of DNA, namely the AA-wedge, junction, and flexible anisotropic dimer models. We further show that recent high-resolution NMR structures of DNA A-tracts are consistent with crystallographically observed structures, and that the combined data provide a realistic basis for describing the behavior of curved DNA in solution.


Roll Angle Minor Groove Major Groove Bend Angle Protein Data Bank Entry 
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Copyright information

© and Springer Science+Business Media 2005

Authors and Affiliations

  • Victor B. Zhurkin
    • 1
  • Michael Y. Tolstorukov
    • 1
  • Fei Xu
    • 2
  • Andrew V. Colasanti
    • 2
  • Wilma K. Olson
    • 2
  1. 1.Laboratory of Experimental and Computational BiologyNational Cancer Institute, NIHBethesdaUSA
  2. 2.Wright-Rieman LaboratoriesRutgers UniversityPiscatawayUSA

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