Tumor Ablation pp 182-191 | Cite as

Image Guidance and Control of Thermal Ablation

  • Ferenc A. Jolesz

Abstract

The physical and biologic principles of localized high-temperature thermal therapy are well understood. If the targeted tissue volume is heated beyond 57° to 60°C, the threshold for protein denaturation, then coagulation necrosis occurs. This type of thermal treatment results in irreversible cell damage in both normal and neoplastic tissues. Since heat energy deposited above this critical level is not selective, thermal ablation is more comparable to surgery than to the more selective hyperthermia. In the case of cryoablation, the underlying physical and biologic principles are less well understood; nevertheless multiple freezings at a relatively low temperature also result in cell death.

Keywords

Image Guidance Magn Reson Image Thermal Ablation Thermal Therapy Percutaneous Cryoablation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bleier AR, Jolesz FA, Cohen MS, et al. Real time magnetic resonance imaging of laser heat deposition in tissue. Magn Reson Med 1991;21:132–137.PubMedCrossRefGoogle Scholar
  2. 2.
    Puccini S, Bar, N-K, Bublat M, Kahn T, Busse H. Simulations of thermal tissue coagulation and their value for the planning and monitoring of laser-induced interstitial theremotherapy (LITT). Magn Reson Med 2003;49:351–362.PubMedCrossRefGoogle Scholar
  3. 3.
    Livraghi L, Goldberg SN, Lazzaroni S, Meloni F, Solbiati L, Gazelle GS. Small hepatocellular carcinoma: treatment with radio-frequency ablation versus ethanol injection. Radiology 1999;210:655–661.PubMedCrossRefGoogle Scholar
  4. 4.
    Goldberg SN, Stein MC, Gazelle GS, Sheiman RG, Kruskal JB, Clouse ME. Percutaneous radiofrequency tissue ablation: optimization of pulsed-radiofrequency technique to increase coagulation necrosis. J Vase Intervent Radiol 1999;10:907–916.CrossRefGoogle Scholar
  5. 5.
    Silverman SG, Tuncali K, Adams DF, et al. MR imaging-guided percutaneous cryotherapy of liver tumors: initial experience. Radiology 2000;217:657–664.PubMedCrossRefGoogle Scholar
  6. 6.
    Matsumoto R, Mulkern RV, Hushek SG, Jolesz FA. Tissue temperature monitoring for thermal interventional therapy: comparison of Tl-weighted MR sequences. J Magn Reson Imaging 1994;4:65–70.PubMedCrossRefGoogle Scholar
  7. 7.
    Jolesz FA, Hynynen K. Magnetic resonance image-guided focused ultrasound surgery. Cancer J 2002;8(suppl l):S100–12.PubMedGoogle Scholar
  8. 8.
    Hynynen K, Pomeroy O, Smith DN, et al. MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast: a feasibility study. Radiology 2001;219:176–185.PubMedCrossRefGoogle Scholar
  9. 9.
    Jolesz FA. Image-guided procedures and the operating room of the future. Radiology 1997;204:601–612.PubMedCrossRefGoogle Scholar
  10. 10.
    Jolesz FA, Nabavi A, Kikinis R. Integration of interventional MRI with computer-assisted surgery. J Magn Reson Imaging 2001;13:69–77.PubMedCrossRefGoogle Scholar
  11. 11.
    Kuroda K, Chung AH, Hynynen K, Jolesz FA. Calibration of water proton chemical shift with temperature for noninvasive temperature imaging during focused ultrasound surgery. J Magn Reson Imaging 1998;8:175–181.PubMedCrossRefGoogle Scholar
  12. 12.
    Stollberger R, Ascher PW, Huber D, Renhart W, Radner H, Ebner F. Temperature monitoring of interstitial thermal tissue coagulation using MR phase images. J Magn Reson Imaging 1997;8:188–196.CrossRefGoogle Scholar
  13. 13.
    Chung AH, Hynynen K, Colucci V, Oshio K, Cline HE, Jolesz FA. Optimization of spoiled gradient-echo phase imaging for in vivo localization of a focused ultrasound beam. Magn Reson Med 1996;36:745–752.PubMedCrossRefGoogle Scholar
  14. 14.
    Kuroda K, Abe K, Tsutsumi S, Ishihara Y, Suzuki Y, Sato K. Water proton magnetic resonance spectroscopic imaging. Biomed Thermol 1994;13:43–62.Google Scholar
  15. 15.
    Jolesz FA, Bleier AR, Jakab P, Ruenzel PW, Huttl K, Jako GJ. MR imaging of laser-tissue interactions. Radiology 1988;168:249–253.PubMedCrossRefGoogle Scholar
  16. 16.
    Lewin JS, Connell CF, Duerk JL, et al. Interactive MRI-guided radiofrequency interstitial thermal ablation of abdominal tumors: clinical trial for evaluation of safety and feasibility. J Magn Reson Imaging 1998;8:40–45.PubMedCrossRefGoogle Scholar
  17. 17.
    Steiner P, Botnar R, Dubno B, Zimmermann GG, Gazelle GS, Debatin JF. Radio-frequency-induced thermoablation: monitoring with Tl-weighted and proton-frequency-shift MR imaging in an interventional 0.5 T environment. Radiology 1998;206:803–810.PubMedCrossRefGoogle Scholar
  18. 18.
    Zhang Q, Chung YC, Lewin JS, Duerk JL. A method for simultaneous RF ablation and MRI. J Magn Reson Imaging 1998;8:110–114.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Ferenc A. Jolesz
    • 1
  1. 1.Division of MRI and Image Guided Therapy Program, Department of RadiologyBrigham and Women’s HospitalBostonUSA

Personalised recommendations