Cutaneous Wound Reepithelialization

A Partial and Reversible EMT
  • Valérie Arnoux
  • Christophe Côme
  • Donna F. Kusewitt
  • Laurie G. Hudson
  • Pierre Savagner
Part of the Molecular Biology Intelligence Unit book series (MBIU)

Abstract

Successful cutaneous wound repair occurs in a series of tightly coordinated and overlapping steps: (1) inflammation and clot formation, (2) keratinocyte activation and migration, (3) remodeling of the basement membrane and extracellular matrix, and (4) dermal and epidermal maturation. During the final three stages of cutaneous wound healing, restoration of an intact epidermis occurs via a complex process termed reepithelialization. In this chapter, we focus on the process of wound reepithelialization, emphasizing the resemblance of reepithelialization to epithelial-mesenchymal transition (EMT) occurring during development and tumor progression. Based on the many morphologic and molecular similarities between the two processes, we propose that wound reepithelialization represents a partial and reversible EMT.

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Copyright information

© Eurekah.com and Kluwer Academic / Plenum Publishers 2005

Authors and Affiliations

  • Valérie Arnoux
    • 1
  • Christophe Côme
    • 1
  • Donna F. Kusewitt
    • 2
  • Laurie G. Hudson
    • 3
  • Pierre Savagner
    • 4
  1. 1.EMI 0229 INSERM: Génotypes et Phénotypes TumorauxCRLC Val d’Aurelle-Paul LamarqueMontpellierFrance
  2. 2.Department of Veterinary BiosciencesThe Ohio State UniversityColumbusUSA
  3. 3.UNM Health Sciences CenterAlbuquerqueUSA
  4. 4.Génotypes et Phénotypes Tumoraux INSERM Bâtiment de Recherche en CancerologieCRLC Val d’Aurelle-Paul LamarqueMontpellier CedexFrance

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