Regulation of E-Cadherin-Mediated Cell-Cell Adhesion by Rho Family GTPases

  • Masato Nakagawa
  • Nanae Izumi
  • Kozo Kaibuchi
Chapter
Part of the Molecular Biology Intelligence Unit book series (MBIU)

Abstract

Cell-cell adhesions are rearranged dynamically during tissue development and tumor metastasis. Recently, Rho-family GTPases, including RhoA, Rac1, and Cdc42, have emerged as key regulators of cadherin-mediated cell-cell adhesion. Following the identification and characterization of regulators and effectors of Rho GTPases, signal transduction pathways from cadherin to Rho GTPases and, in turn, from Rho GTPases to cadherin are beginning to be clarified.

Keywords

Guanine Nucleotide Exchange Factor Epithelial Phenotype Curr Opin Cell Biol MDCKII Cell Cadherin Superfamily 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Eurekah.com and Kluwer Academic / Plenum Publishers 2005

Authors and Affiliations

  • Masato Nakagawa
    • 1
  • Nanae Izumi
    • 1
  • Kozo Kaibuchi
    • 1
  1. 1.Department of Cell PharmacologyNagoya University, Graduate School of MedicineShowa, NagoyaJapan

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