Overview of Management of Differentiated Thyroid Carcinoma in Patients with Negative Whole Body Radioiodine Scans and Elevated Serum Thyroglobulin Levels

  • Ernest L. Mazzaferri

Keywords

Thyroid Cancer Papillary Thyroid Carcinoma Differentiate Thyroid Cancer Differentiate Thyroid Carcinoma Thyroid Remnant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bachelot, A, AF Cailleux, M Klain, E Baudin, M Ricard, N Bellon, B Caillou, JP Travagli, and M Schlumberger. 2002. Relationship between tumor burden and serum thyroglobulin level in patients with papillary and follicular thyroid carcinoma. Thyroid. 12:707–711.CrossRefPubMedGoogle Scholar
  2. Bal, CS, A Kumar, P Chandra, SN Dwivedi, and S Mukhopadhyaya. 2004. Is chest x-ray or high-resolution computed tomography scan of the chest sufficient investigation to detect pulmonary metastasis in pediatric differentiated thyroid cancer? Thyroid. 14:217–225.CrossRefPubMedGoogle Scholar
  3. Bal, CS, AK Padhy, and A Kumar. 2001. Clinical features of differentiated thyroid carcinoma in children and adolescents from a sub-Himalayan iodine-deficient endemic zone. Nucl Med Commun 22:881–887.CrossRefPubMedGoogle Scholar
  4. Baloch, Z, P Carayon, B Conte-Devolx, LM Demers, U Feldt-Rasmussen, JF Henry, VA LiVosli, P Niccoli-Sire, R John, J Ruf, PP Smyth, CA Spencer, and JR Stockigt. 2003. Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease. Thyroid 13:3–126.PubMedGoogle Scholar
  5. Barbaro, D, G Boni, G Meucci, U Simi, P Lapi, P Orsini, C Pasquini, F Piazza, M Caciagli, and G Mariani. 2003. Radioiodine treatment with 30 mCi after recombinant human thyrotropin stimulation in thyroid cancer: effectiveness for postsurgical remnants ablation and possible role of iodine content in L-thyroxine in the outcome of ablation. J Clin Endocrinol Metab 88:4110–4115.CrossRefPubMedGoogle Scholar
  6. Baudin, E, CD Cao, AF Cailleux, S Leboulleux, JP Travagli, and M Schlumberger. 2003. Positive predictive value of serum thyroglobulin levels, measured during the first year of follow-up after thyroid hormone withdrawal, in thyroid cancer patients. J Clin Endocrinol Metab 88:1107–1111.CrossRefPubMedGoogle Scholar
  7. Berg, G, G Lindstedt, M Suurkula, and S Jansson. 2002. Radioiodine ablation and therapy in differentiated thyroid cancer under stimulation with recombinant human thyroid-stimulating hormone. J Endocrinol Invest 25:44–52.PubMedGoogle Scholar
  8. Cailleux, AF, E Baudin, JP Travagli, M Ricard, and M Schlumberger. 2000. Is diagnostic iodine-131 scanning useful after total thyroid ablation for differentiated thyroid cancer? J Clin Endocrinol Metab 85:175–178.CrossRefPubMedGoogle Scholar
  9. Casara, D, D Rubello, G Saladini, G Masarotto, A Favero, ME Girelli, and B Busnardo. 1993. Different features of pulmonary metastases in differentiated thyroid cancer: natural history and multivariate statistical analysis of prognostic variables. J Nucl Med 34:1626–1631.PubMedGoogle Scholar
  10. de Keizer, B, HP Koppeschaar, PM Zelissen, CJ Lips, PP Van Rijk, A van Dijk, and JM de Klerk. 2001. Efficacy of high therapeutic doses of iodine-131 in patients with differentiated thyroid cancer and detectable serum thyroglobulin. Eur J Nucl Med 28:198–202.PubMedGoogle Scholar
  11. Fatourechi, V, ID Hay, H Javedan, GA Wiseman, BP Mullan, and CA Gorman. 2002. Lack of impact of radioiodine therapy in Tg-positive, diagnostic whole-body scan-negative patients with follicular cell-derived thyroid cancer. J Clin Endocrinol Metab 87:1521–1526.PubMedGoogle Scholar
  12. Jarzab, B, D Handkiewicz-Junak, J Roskosz, Z Puch, Z Wygoda, A Kukulska, B Jurecka-Lubieniecka, K Hasse-Lazar, M Turska, and A Zajusz. 2003. Recombinant human TSH-aided radioiodine treatment of advanced differentiated thyroid carcinoma: a single-centre study of 54 patients. Eur J Nucl Med Mol Imaging 30:1077–1086.PubMedGoogle Scholar
  13. Koh, JM, ES Kim, JS Ryu, SJ Hong, WB Kim, and YK Shong. 2003. Effects of therapeutic doses of 131I in thyroid papillary carcinoma patients with elevated thyroglobulin level and negative 131I whole-body scan: comparative study. Clin Endocrinol (Oxford) 58:421–427.CrossRefGoogle Scholar
  14. Koong, SS, JC Reynolds, EG Movius, AM Keenan, KB Ain, MC Lakshmanan, and J Robbins. 1999. Lithium as a potential adjuvant to 131I therapy of metastatic, well differentiated thyroid carcinoma. J Clin Endocrinol Metab 84:912–916.CrossRefPubMedGoogle Scholar
  15. Mazzaferri, EL. 1995. Treating high thyroglobulins with radioiodine. A magic bullet or a shot in the dark? J Clin Endocrinol Metab 80:1485–1487.CrossRefPubMedGoogle Scholar
  16. Mazzaferri, EL, and RT Kloos. 2000. Using recombinant human TSH in the management of well-differentiated thyroid cancer: current strategies and future directions. Thyroid 10:767–778.PubMedGoogle Scholar
  17. Mazzaferri, EL, and RT Kloos. 2001. Current approaches to primary therapy for papillary and follicular thyroid cancer. J Clin Endocrinol Metab 86:1447–1463.CrossRefPubMedGoogle Scholar
  18. Mazzaferri, EL, and RT Kloos. 2002. Is diagnostic iodine-131 scanning with recombinant human TSH (rhTSH) useful in the follow-up of differentiated thyroid cancer after thyroid ablation? J Clin Endocrinol Metab 87:1490–1498.CrossRefPubMedGoogle Scholar
  19. Mazzaferri, EL, RJ Robbins, CA Spencer, LE Braverman, F Pacini, L Wartofsky, BR Haugen, SI Sherman, DS Cooper, GD Braunstein, S Lee, TF Davies, BM Arafah, PW Ladenson, and A Pinchera. 2003. A consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma. J Clin Endocrinol Metab 88:1433–1441.PubMedGoogle Scholar
  20. McDougall, IR. 1997. 131I treatment of 131I negative whole body scan, and positive thyroglobulin in differentiated thyroid carcinoma: what is being treated? Thyroid 7:669–672.PubMedGoogle Scholar
  21. Pachucki, J, and LA Burmeister. 1997. Evaluation and treatment of persistent thyroglobulinemia in patients with well-differentiated thyroid cancer. Eur J Endocrinol 137:254–261.CrossRefPubMedGoogle Scholar
  22. Pacini, F, L Agate, R Elisei, M Capezzone, C Ceccarelli, F Lippi, E Molinaro, and A Pinchera. 2001. Outcome of differentiated thyroid cancer with detectable serum Tg and negative diagnostic 131-I whole body scan: comparison of patients treated with high 131-I activities versus untreated patients. J Clin Endocrinol Metab 86:4092–4097.PubMedGoogle Scholar
  23. Pacini, F, F Lippi, N Formica, R Elisei, S Anelli, and C Ceccarelli. 1987. Therapeutic doses of iodine-131 reveal undiagnosed metastases in thyroid cancer patients with detectable serum thyroglobulin levels. J Nucl Med 28:1888–1891.PubMedGoogle Scholar
  24. Pineda, JD, T Lee, K Ain, J Reynolds, and J Robbins. 1995. Iodine-131 therapy for thyroid cancer patients with elevated thyroglobulin and negative diagnostic scan. J. Clin. Endocrinol. Metab. 80:1488–1492.CrossRefPubMedGoogle Scholar
  25. Robbins, RJ, SM Larson, N Sinha, A Shaha, C Divgi, KS Pentlow, R Ghossein, and RM Tuttle. 2002. A retrospective review of the effectiveness of recombinant human TSH as a preparation for radioiodine thyroid remnant ablation. J Nucl Med 43:1482–1488.PubMedGoogle Scholar
  26. Ronga, G, A Fiorentino, E Paserio, A Signore, V Todino, MA Tummarello, M Filesi, and I Baschieri. 1990. Can iodine-131 whole-body scan be replaced by thyroglobulin measurement in the post-surgical follow-up of differentiated thyroid carcinoma? J Nucl Med 31:1766–1771.PubMedGoogle Scholar
  27. Samuel, AM, B Rajashekharrao, and DH Shah. 1998. Pulmonary metastases in children and adolescents with well-differentiated thyroid cancer. J Nucl Med 39:1531–1536.PubMedGoogle Scholar
  28. Schaap, J, CF Eustatia-Rutten, M Stokkel, TP Links, M Diamant, EA van der Velde, JA Romijn, and JW Smit. 2002. Does radioiodine therapy have disadvantageous effects in non-iodine accumulating differentiated thyroid carcinoma? Clin Endocrinol (Oxford) 57:117–124.CrossRefGoogle Scholar
  29. Scheumann, GFW, H Seeliger, TJ Musholt, O Gimm, G Wegener, H Dralle, H Hundeshagen, and R Pichlmayr. 1996. Completion thyroidectomy in 131 patients with differentiated thyroid carcinoma. Acta Chir Eur J Surg 162:677–684.Google Scholar
  30. Schlumberger, MJ. 1999. Diagnostic follow-up of well-differentiated thyroid carcinoma: historical perspective and current status. J Endocrinol Invest 22(Suppl. 11):3–7.PubMedGoogle Scholar
  31. Schlumberger, M, O Arcangioli, JD Piekarski, M Tubiana, and C Parmentier. 1988. Detection and treatment of lung metastases of differentiated thyroid carcinoma in patients with normal chest X-rays. J Nucl Med 29:1790–1794.PubMedGoogle Scholar
  32. Schlumberger, M, G Berg, O Cohen, L Duntas, F Jamar, B Jarzab, E Limbert, P Lind, F Pacini, C Reiners, FS Franco, A Toft, and WM Wiersinga. 2004. Follow-up of low-risk patients with differentiated thyroid carcinoma: a European perspective. Eur J Endocrinol 150:105–112.CrossRefPubMedGoogle Scholar
  33. Schlumberger, M, F Mancusi, E Baudin, and F Pacini. 1997. 131-I therapy for elevated thyroglobulin levels. Thyroid 7:273–276.PubMedGoogle Scholar
  34. Sisson, JC, TJ Giordano, DA Jamadar, EA Kazerooni, B Shapiro, MD Gross, SA Zempel, and SA Spaulding. 1996. 131-I treatment of micronodular pulmonary metastases from papillary thyroid carcinoma. Cancer 78:2184–2192.CrossRefPubMedGoogle Scholar
  35. Van Tol, KM, PL Jager, EG De Vries, DA Piers, HM Boezen, WJ Sluiter, RP Dullaart, and TP Links. 2003. Outcome in patients with differentiated thyroid cancer with negative diagnostic whole-body scanning and detectable stimulated thyroglobulin. Eur J Endocrinol 148:589–596.PubMedGoogle Scholar
  36. Yeh, MW, O Demircan, P Ituarte, and OH Clark. 2004. False-negative fine-needle aspiration cytology results delay treatment and adversely affect outcome in patients with thyroid carcinoma. Thyroid 14:207–215.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Ernest L. Mazzaferri
    • 1
    • 2
  1. 1.Department of MedicineUniversity of Florida College of MedicineUSA
  2. 2.Ohio State UniversityUSA

Personalised recommendations