The Aluminium-Amyloid Cascade Hypothesis and Alzheimer’s Disease

Aluminium and β-amyloid
  • Christopher Exley
Part of the Subcellular Biochemistry book series (SCBI, volume 38)

Abstract

Aluminium (Al) is found associated with β-amyloid (Aβ) in the brain in Alzheimer’s disease. Al precipitates Aβ in vitro as distinct fibrillar structures composed of β-pleated sheets of peptide. The aetiology of their association in vivo is not known. Al is known to increase the brain Aβ burden in experimental animals and this might be due to a direct influence upon Aβ anabolism or direct or indirect affects upon Aβ catabolism. It is difficult to rationalise from an evolutionary perspective the precipitation and persistence of Aβ in vivo. However, Al has not been subject to the same evolutionary pressures as Aβ, it is a recent addition to the biotic environment, and its precipitation of Aβ may have only been subjected to natural selection in the recent past. Whether AD is also part of this ongoing selection process remains to be elucidated

Key words

Aluminium Aβ APP metabolism Aβ aggregation Aβ catabolism Aβ neurotoxicity 

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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Christopher Exley
    • 1
  1. 1.Birchall Centre for Inorganic Chemistry and Materials ScienceKeele UniversityStaffordshireUK

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