Phosphatidylinositol 3-kinase, Phosphoinositides and Apoptosis

Polyphosphoinositol phosphatase and apoptosis
  • Gabriella Sarmay
Chapter
Part of the Subcellular Biochemistry book series (SCBI, volume 36)

Keywords

Focal Adhesion Kinase PTEN Expression Human Breast Carcinoma Cell Integrin Link Kinase Focal Adhesion Kinase Phosphorylation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aman, M.J., Lamkin, T.D., Okada, H., Kurosaki, T., and Ravichandran, K.S., 1998, The inositol phosphatase SHIP inhibits Akt/PKB activation in B cells. J. Biol. Chem. 273: 33922–33928.PubMedCrossRefGoogle Scholar
  2. Aman, M.J., Walk, S.F., March, M.E., Su, H-P. Carver, D.J., and Ravichandran, K.S., 2000, Essential role for the C-terminal noncatalytic region of SHIP in FcRIIb1 mediated inhibitory signaling. Mol. Cell. Biol. 20: 3576–3589.PubMedCrossRefGoogle Scholar
  3. Anderson, K.E., Coadwell, J., Stephens, L.R., and Hawkins, P.T., 1998, Translocation of PDK1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B. Curr. Biol., 8:684–691.PubMedCrossRefGoogle Scholar
  4. Borlando, L.R., Redondo, C., Alvarez, B., Jimenez, C., Criado, L.M., Flores, J., Marcos, M.A. Martinez, A.C., Balomenos D., and Carrera, A.C., Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo. (2000) FASEB J. 14: 895–903.Google Scholar
  5. Brauweiler, A., Tamir, I., Dal Porto, J., Benschop, R.J., Helgason, C.D., Humphries, R.K., Freed, J.H. and Cambier, J.C., 2000, Differential regulation of B cell development, activation, and death by the Src homology 2 domain-containing 5′inositol phosphatase (SHIP). J. Exp. Med. 191: 1545–1554.PubMedCrossRefGoogle Scholar
  6. Cantley, L.C., and Neel, B., 1999, New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/Akt pathway. Proc. Natl. Acad. Sci. 96: 4240–4245.PubMedCrossRefGoogle Scholar
  7. Cantrell, D.A., 2001, Phosphoinositide 3-kinase signaling pathways. J. Cell Science, 114: 1439–1445.PubMedGoogle Scholar
  8. Cardone, M.H., Roy N., Stennicke, H.R., Salvesen, G.S., Franke, T.F., Stanbridge, E., Frisch, S., and Reed, J.C., 1998, Regulation of cell death protease caspase-9 by phosphorylation. Science, 282: 1318–1321PubMedCrossRefGoogle Scholar
  9. Carpenter, C. L., and Cantley, L. C., 1996, Phosphoinositide 3-kinase and the regulation of cell growth. Biochim. Biophys. Acta, 1288: M11–16.PubMedGoogle Scholar
  10. Carson, J.P., Kulik, G., Weber, M.J. 1999, Antiapoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of phosphatidylinositol 3′-kinase and Akt/protein kinase B. Cancer Res Apr 59: 1449–1453Google Scholar
  11. Carver, D.J., Aman, M.J., and Ravichandran, K.S., 2000, SHIP inhibits Akt activation in B cells through regulation of Akt membrane localization. Blood, 96: 1449–1456.PubMedGoogle Scholar
  12. Clement S, Krause U, Desmedt F, Tanti J.F, Behrends J., Pesesse X., Sasaki T., Penninger J., Doherty M., Malaisse W., Dumont J.E., Le Marchand-Brustel Y., Erneux C., Hue L., and Schurmans S., 2001 The lipid phosphatase SHIP2 controls insulin sensitivity. Nature, 409:92–97.PubMedGoogle Scholar
  13. Chacko GW, Tridandapani S, Damen, J.E., Liu L., Krystal G., and Coggeshall, K.M., 1996, Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa isositol polyphosphate 5-phosphatase, SHIP. J Immunol 157: 2234–2238.PubMedGoogle Scholar
  14. Cockroft, S., and Thomas, G.M.H., 1992, Inositol lipid specific phospholipase C isoenzymes and their differential regulation by receptors. Biochem. J. 288: 1–14.Google Scholar
  15. Coggeshall, K.M., 1998, Inhibitory signaling by B cell FeγR∐b, Curr. Op. Immunol. 10: 306–312Google Scholar
  16. Craven, S.E., and Bredt, D.S., 1998, PDZ proteins organize synaptic signaling pathways. Cell, 93: 495–498.PubMedCrossRefGoogle Scholar
  17. Dahia, P.L., Aquiar, R.C., Alberta, J., Kum, J.B., Caron, S., Sill, H., Marsh, D.J., Ritz, J., Freedman, A., Stiles, C., and Eng, C., 1999, PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin hemeatological malignancies. Hum. Mol. Genet. 8: 185–193PubMedCrossRefGoogle Scholar
  18. Damen, J.E., Liu, L, Rosten, P., Humphries, R.K., Jefferson, A.B., Majerus, P., and Krystal, G., 1996, The 145 kDa protein induce to associate with Shc by multiple cytokines is an inositol tetraphosohate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase. Proc. Natl. Acad. Sci. USA 93: 1689–1693.PubMedCrossRefGoogle Scholar
  19. Damen, J.E., Liu, L, Ware, M.D., Ermolaeva, M., Majerus, P.W., and Krystal, G., 1998, Multiple forms of the SH2-containing inositol phosphatase, SHIP, are generated by C-terminal truncation. Blood, 92: 1199–1205.PubMedGoogle Scholar
  20. Damen, J.E. Ware, M.D., Kalesnikoff, J., Hughes, M.R. and Krystal, G., 2001, SHIP’S C terminus is essential for ist hydrolysis of PIP3 and inhibition of mast cell-degranulation. Blood, 97: 1343–1351.PubMedCrossRefGoogle Scholar
  21. Di Cristofano, A., Pesce, B., Cordon-Cardo, C., Pandolfi, P.P., 1998, Pten is essential for embryonic development and tumor suppression. Nat. Genet., 19: 348–355.PubMedGoogle Scholar
  22. Divecha, N., and Irvine, R.F., 1995, Phospholipid signaling. Cell, 80: 269–278.PubMedCrossRefGoogle Scholar
  23. Drachman, J.G., Griffin, J.D., and Kaushansky, K., 1995, The c-Mpl ligand (thrombopoetin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl. J. Biol. Chem., 270: 4979–4982.PubMedGoogle Scholar
  24. Erneux, C., Goaverts, C., Communi, D., and Pesesse, X., 1998, The diversity and possible functions of the inositolpolyphosphate 5-phosphatase. Biochim. Biophys. Acta 1436: 185–199.PubMedGoogle Scholar
  25. Franke, T.F., Kaplan, D.R., and Cantley, L.C., 1997, PI3K: Downstream action blocks apoptosis. Cell, 88: 435–437.PubMedCrossRefGoogle Scholar
  26. Furnari, F.B., Huang, H.J., Cavenee, W.K., 1998, The phosphatidylinositol phosphatase activity of PTEN mediates a serum-sensititve G1 growth arrest in glioma cells. Cancer Res, 58: 5002–5008.PubMedGoogle Scholar
  27. Ge, N.L., and Rudikoff, S., 2000, Expression of PTEN in PTEN-deficient multiple myeloma cells abolishes tumor growth in vivo. Oncogene 19: 4091–4095.PubMedCrossRefGoogle Scholar
  28. Geier, S.J., Algate, P.A., Carlberg, K., Flowers, D., Friedman, C., Trask, B., and Rohrschneider, L.R. 1997, The human SHIP gene is differentially expressed in cell lineages of the bone marrow and blood. Blood, 89: 1876–1885.PubMedGoogle Scholar
  29. Gold, M.R., Ingham, R.J., McLeod, S.J., Christian, S.L., Scheid, M.P., Duronio, V., Santos, L., and Matsuuchi, L., 2000, Targets of B cell antigen receptor signaling: the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3 signaling pathway and the Rapl GTPase. J. Exp. Med. 176: 47–68.Google Scholar
  30. Ghosh, A.K., Grigorieva, I., Steele, R., Hoover, R.G., Ray, R.B., 1999, PTEN transcriptionally modulates c-myc gene expression in human breast carcinoma cells and is involved in cell growth regulation. Gene, 235: 85–91.PubMedCrossRefGoogle Scholar
  31. Gupta, N., Scharenberg, A.M., Fruman, D.A., Cantley, L.C., Kinet, J-P., and Long, E.O., 1999, The SH2 domain containing inositol 5′-phosphatase (SHIP) recruits the p85 subunit of phosphoinositide 3-kinase during Fe□R∐bl-mediared inhibition of B cell receptor signaling. J. Biol. Chem. 274: 7489–7494.PubMedGoogle Scholar
  32. Harmer, S.L., and DeFranco, A.L., 1999, The Src homology domain 2-containing inositol phosphatase SHIP forms a ternary complex with Shc and Grb2 in antigen receptor stimulated B lymphocytes. J. Biol. Chem. 274: 12183–12191.PubMedCrossRefGoogle Scholar
  33. Helgason, C.D., Damen, J.E., Rosten, P., Grewal, R., Sorensen, P., Chappel, S.M., Borowsky, A., Jirik, F., Krystal, G. and Humphries, R.K., 1998, Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology and a shortened lifespan. Genes Dev. 12:1610–1620PubMedGoogle Scholar
  34. Helgason, C.D., Kalberer, C.P., Damen, J.E., Chappel, S.M., Pineault, N., Krystal, G., and Humphries, R.K., 2000, A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of B lymphocytes in ship-/-mice. J Exp Med. 191: 5781–5794.CrossRefGoogle Scholar
  35. Huber, M., Helgason, CD, Damen, J.E., Scheid, M., Duronio, V., Liu, L., Ware, M.D., Humphries R.K., and Krystal, G., 1999, The role of SHIP in growth factor induced signaling. Progress Biophys. Mol. Biol. (Pawson A.J. ed.) pp. 423–434. Elsevier Science, The Netherlands.Google Scholar
  36. Ingham R.J., Holgado-Madruga, M., Siu, C., Wong, A.J., and Gold, M.R., 1998, The Gab1 protein is a docking site for multiple proteins involved in signaling by the B cell antigen receptor. J. Biol. Chem. 273: 30630–30637.PubMedCrossRefGoogle Scholar
  37. Ishihara, H., Sasaoka, T., Hori, H., Wada, T., Hirai, H., Haruta, T., Langlois, W.J., and Kobayashi, M., 1999, Molecular cloning of rat SH2-containing inositol phosphatase 2 (SHIP2) and its role in the regulation of insulin siganling. Biochim. Biophys. Res. Commun. 260: 265–272.CrossRefGoogle Scholar
  38. Kennedy, S.G., Wagner, A.J., Conzen, S.D., Jordán, J., Bellacosa, A., Tsichlis, P.N. and Hay, N., 1997, The PI3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Develop. 11: 701–713.PubMedGoogle Scholar
  39. Kimura T., Sakamoto, H., Appella, E., and Siraganian, R.P. 1997. The negative signaling molecule SH2 domain containing inositol polyphosphate 5-phosphatase (SHIP) binds to the tyrosine phosphorylated β subunit of the high affinity IgE receptor. J. Bio. Chem. 272: 13991–13996.Google Scholar
  40. Kinoshita, T., Yokota, T., Arai, K., and Miyajima, A., 1995, Suppression of apoptotic death in hematopoietic cells by signaling through the IL-3/GM-CSF receptors. EMBO J., 14: 266–275.PubMedGoogle Scholar
  41. Koncz, G., Pecht, I., Gergely, J., and Sármay, G., 1999, Feγ receptor mediated inhibition of human B cell activation: the role of SHP-2 phosphatase. Eur. J. Immunol. 29: 1980–1989.PubMedCrossRefGoogle Scholar
  42. Kuroiwa, A., Yamashita, Y., Inui, M., Yuasa, T., Ono, M., Nagabukuro, A., Matsuda, Y., and Takai, T., 1998, Association of tyrosine phosphatases SHP-1 and SHP-2, inositol 5-phosphatase SHIP with gp49B1 and chromosomal assignment of the gene. J. Biol. Chem. 273: 1070–1074.PubMedCrossRefGoogle Scholar
  43. Kyrylenko, S., Roschier, M., Korhonen, P., Salminen, A. 1999, Regulation of PTEN expression in neuronal apotosis. Brain Res. Mol. Brain Res. 73: 198–202.PubMedGoogle Scholar
  44. Lecoq-Lafon, C., Verdier, F., Fichelson, S., Chretien, S., Gisselbrecht, S., Lacombe, C., Mayeux, P., 1999, Erythropoietin induces the tyrosine phosphorylation of Gab1 and its association with SHC, SHP2 SHIP ans phosphatidylinositol 3-kinase. Blood, 93: 2578–2585PubMedGoogle Scholar
  45. Lemmon, M.A., Falsca, M., Ferguson, K.M., and Schlessinger, J., 1997, Regulatory recruitment of signaling molecules to the cell membrane by pleckstrin homology domains. Trends Cell. Biol., 7: 237–242.Google Scholar
  46. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S.I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S.H., Giovanella, B.C., Ittmann, M., Tycko, B., Hibshoosh, H., Wigler, M.H. and Parsons, R., 1997, PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast and prostate cancer. Science, 275:1943–1947.PubMedCrossRefGoogle Scholar
  47. Li, D.M., and Sun H., 1997, TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor. Cancer Res. 57: 2124–2129.PubMedGoogle Scholar
  48. Lioubin, M.N., Algate, P.A., Tsai, S., Carlberg, K., Aebersold, R., and Rohrschneider, L.R., 1996, pl50Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity. Genes Dev. 10: 1084–1095.PubMedGoogle Scholar
  49. Liscovitch, M. and Cantley, L.C., 1994, Lipid second messengers. Cell, 77: 329–334.PubMedCrossRefGoogle Scholar
  50. Liu L, Damen JE, Cutler RL, and Krystal G., 1994, Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc. Mol Cell Biol. 14: 6926–6935.PubMedGoogle Scholar
  51. Liu, L., Damen, J.E., Hughes, M.R., Babic, I., Jirik, F.R., and Krystal, G., 1997. The Src homology 2 (SH2) domain of SH2-containing inositol phophatase (SHIP) is essential for tyrosine phosphorylatio of SHIP, its association with Shc and its induction of apoptosis. J. Biol. Chem. 272: 8983–8988.PubMedGoogle Scholar
  52. Liu, Q., Shalaby, F., Jones, J., Bouchard, D., and Dumont, D.J., 1998, The SH2-containing inositol poliphosphate 5-phosphatase, Ship, is expressed during hematopoiesis and spermatogenesis. Blood, 91: 2753–2759.PubMedGoogle Scholar
  53. Liu, Q., Sasaki, T., Kozieradzki, I., Wakeham, A., Itie, A., Dumont, D.J., and Penninger, J.M., 1999, SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival. Genes Dev 13: 786–791.PubMedGoogle Scholar
  54. Lu, Y., Lin, Y.Z., LaPushin, R., Cuevas, B., Fang, X., Yu, S.X., Davies, M.A., Khan, H., Furui, T., Mao, M., Zinner, R., Hung, M.C., Steck, P., Siminovitch, K., and Mills, G.B., 1999, The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells. Oncogene, 18: 7034–7045.PubMedGoogle Scholar
  55. Maehama, T., and Dixon, J.E., 1998, The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273: 13375–13378.PubMedCrossRefGoogle Scholar
  56. Matsuguchi T., Salgia R, Hallek M, Eder M, Druker B, Ernst TJ, and Griffin JD., 1994, Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony-stimulating factor, interleukin-3, and Steel factor is constitutively increased by p210BCR/ABL. J. Biol. Chem. 269: 5016–5021.PubMedGoogle Scholar
  57. Mikhalap, S.W., Shlapatska L.M., Berdova, A.G., Law, C.-L., Clark, E.A, and Sidorenko, S.P., 1999, CDw 150 associates with Src-homology 2-containinng inositol phosphatase and modulates CD95-mediated apoptosis. J. Immunol. 162: 5719–5727.PubMedGoogle Scholar
  58. Muraille, E., Pesesse, X., Kuntz, C., and Erneux, C., 1999, Distribution of the Src homology 2 domain-containing inositol 5-phophatase, SHIP-2 in both non-hemeatopoietic and hemeopoietic cells and possible invovlvement of SHIP-2 in negative signaling of B cells. Biochem. J., 342: 697–705.PubMedCrossRefGoogle Scholar
  59. Myers, M.P., Pass, I., Batty, I.H., Van der Kaay, J., Stolarov, J.P., Hemmings, B.A., Wigler, M.H., Downes, C.P., and Tonks, N.K., 1998, The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc. Natl. Acad. Sci. USA, 95: 13513–13518.PubMedCrossRefGoogle Scholar
  60. Norvell, A., Mandik, L., and Monroe, J.G., 1995, Engagement of the antigen receptor on immature murine B lymphocytesresults in death by apoptosis. J. Immunol. 154: 4404–4413.PubMedGoogle Scholar
  61. Odai, H., Sasaki, K., Iwamatsu, A., Nakamoto, T., Ueno, H., Yamagata, T., Mitani, K., Yazaki, Y., and Hirai, H., 1997, Purification and molecular cloning of SH2 and SH3 containing inositol polyphosphat 5′ phosphatase, which is involved in the signaling pathway of granulocyte macrophage coclony stimulating factor, erythropoietin, and Bcr-Abl. Blood, 89: 2745–2756.PubMedGoogle Scholar
  62. Ono, M., Bolland, S., Tempst, P., and Ravetch, J.V., 1996, Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FcγRIIB. Nature, 383: 263–266.PubMedCrossRefGoogle Scholar
  63. Ono, M., Okada, H., Bolland, S., Yanagi, S., Kurosaki, T., and Ravetch, J.V., 1997, Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling. Cell, 90: 293–301.PubMedCrossRefGoogle Scholar
  64. Osborn, M.A., Zenner, G., Lubinus M., Zhang X., Songyang, Z., Cantley, L.C., Majerus, P., Burns, P., and Kochan, J.P., 1996, The inositol 5-phosphatase SHIP binds to the mmunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation. J. Biol. Chem. 271: 29271–29278.Google Scholar
  65. Oshimi, Y., and Miyazaki, S., 1995, Fas antigen mediated DNA fragmentation and apoptotic morphological changes are regulated by elevated cytosolic Ca2+ level. J. Immunol. 154: 599–609PubMedGoogle Scholar
  66. Pearse, R.N., Kawabe, T., Bolland, S., Guinamard, R., Kurosaki, T., and Ravetch, J.V., 1999, SHIP recruitment attenuates Fc gamma RIIB-induced B cell apoptosis. Immunity, 10: 6753–6760.CrossRefGoogle Scholar
  67. Persad, S., Attwell, S. Gray, V., Delcomenne, M., Troussard, A., Sanghera, J., and Dedhar, S., 2000, Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proc. Natl. Acad. Sci. U S A, 97: 3207–3212.PubMedCrossRefGoogle Scholar
  68. Pesesse, X., Deleu, S., De Smedt, F., Drayer, L., Erneux, C., 1997, Identification of a second SH2-domain containing protein closely related to the phosphatidyl inositol polyphosphate 5-phosphatase SHIP. Biochem. Biophys. Res. Commun. 239: 697–700.PubMedCrossRefGoogle Scholar
  69. Pesesse, X., Moreau, C., Drayer, A.L., Woscholski, R, Parker, P., and Erneux, C. 1998, The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5 trisphosphate and inositol 1,3,4,5 tetrakisphosphate 5-phosphatase activity. FEBS Lett. 437: 301–303.PubMedCrossRefGoogle Scholar
  70. Petrie, R.J., Schnetkamp, P.P., Patel, K.D., Awashtikalia M., and Deans, J.P., 2000, Transient transaction of the B cell receptor and src homology 2 domain-containing inositol 5 phosphatase to lipid rafts evidence toward a role in calcium regulation. J. Immunol. 165: 1220–1227.PubMedGoogle Scholar
  71. Podsypanina, K., Ellenson, L.H., Nemes, A., Gu, J., Tamura, M., Yamada, K.M., Cordon-Cardo, C., Catoretti, G., Fisher, P.E., and Parsons, R., 1999, Mutation of PTEN/MMAC1 in mice causes neoplasia in multiple organ sytems. Proc. Natl. Acad. Sci. USA 96: 1563–1568.PubMedCrossRefGoogle Scholar
  72. Poque, S.L., Kurosaki, T., Bolen, J., Herbst, R., 2000, B cell antigen receptor-induced activation of Akt promotes B cell survival and is dependent on Syk kinase. J. Immunol. 165: 1300–1306.Google Scholar
  73. Pumphrey N.J., Taylor, V.; Freeman, S.; Douglas, MR.; Bradfield, PF.; Young, SP.; Lord, JM.; Wakelam, MJ.; Bird, IN.; Salmon, M.; Buckley, CD., 1999, Differential association of cytoplasmic signaling molecules SHP-1, SHP-2 SHIP and phospholipase Cγl with PECAM1/CD31. FEBS Lett. 450: 77–83.PubMedCrossRefGoogle Scholar
  74. Rameh, L.E., and Cantley, L.C., 1999, The role of phosphoinositide 3-kinase lipid products in cell function. J. Biol. Chem. 274: 8347–83550.PubMedCrossRefGoogle Scholar
  75. Ravichandran, K.S., Lee, K.K., Songyang, Z., Cantley, L.C., Burn, P., and Burakoff, S.J., 1993, Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation. Science, 262: 902–905PubMedGoogle Scholar
  76. Sakurada, A., Hamada, H., Fukushige, S., Yokoyama, T., Yoshinaga, K., Furukawa, T., Sato, S., Yaiima, A., Sato, M., Fujimura, S., and Horii, A., 1999, Adenovirus-mediated delivery of the PTEN gene inhibits cell growth by induction of apoptosis in endometrial cancer. Int. J. Oncol. 15: 1069–1074PubMedGoogle Scholar
  77. Sámmy, G., Koncz, G. and Gergely, J., 1996, Human type II Fcγ receptors inhibit B cell activation by interacting with the p21tas-dependent pathway. J. Biol. Chem. 271: 30499–30504.Google Scholar
  78. Sármay, G., Koncz, G., Pecht, I., and Gergely, J., 1999, Cooperation between SHP-2 phosphatidyl inositol 3-kinase and phosphoinosito 15-phosphatase in the FcγRIIb mediated B cell regulation. 1mm. Lett. 68: 25–34.Google Scholar
  79. Sattler, M., Salgia, R., Shrikhande, G., Verma, S., Choi, J.L., Rohrschneider, L.R., and Griffin, J.D., 1997, The phosphatidylinositol polyphosphate 5-phosphatase SHIP and the protein tyrosine phosphatase SHP-2 form a complex in hematopoietic cells which can be regulated by BCR/ABL and growth factors. Oncogene, 15: 2379–2384.PubMedCrossRefGoogle Scholar
  80. Saxton, T.M., Oostween, I., Bowtell, D., Aebersold R., and Gold, M.R., 1994, B cell antigen receptor crosslinking induces phosphorylation of the ras activators SHC and mSOS1 as well as the assembly of complexes containing SHC, Grb2 and SOS1 and a 145 kDa tyrosine phosphorylated protein. J. Immunol. 153: 623–636.PubMedGoogle Scholar
  81. Sayos, J., Wu, C., Morra, M., Wang, N., Zhang, X., Allen, D., van Schaik, S., Notarangelo, L., Geha, R., Roncarolo, M.G., Oettgen, H., De Vries, J.E. and Terhorst, C., 1998, The X-linked lymphoproliferative disease gene product, SAP regulates signals induced through the co-receptor, SLAM. Nature, 395: 462–464.PubMedCrossRefGoogle Scholar
  82. Smit, L., de Vries-Smits, A.M.M., Bos, J.L., and Borst, J., 1994, B cell antigen receptor stimulation induces formation of a Shc-Grb2 complex containing multiple tyrosine-phosphorylated proteins. J. Biol. Chem. 269: 20209–20212PubMedGoogle Scholar
  83. Stambolic, V., Suzuki, A., de la Pompa, J.L., Brothers, G.M., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J.M., Siderovski, D.P., and Mak, T.W., 1998, Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell, 95: 29–39.PubMedCrossRefGoogle Scholar
  84. Steck, P.A., Pershouse, M.A., Jasser, S.A., Yung, W.K., Lin, H., Ligon, A.H., Langford, L.A., Baumgard, M.L., Hattier, T., Davies, T., 1997, Identification of a candidate tumor suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet. 15: 356–362.PubMedCrossRefGoogle Scholar
  85. Suzuki, A., de la Pompa, J.L., Stambolic, V., Elia, A.J., Sasaki, T., del Barco Barrantes, I., Ho, A., Wakeham, A., Itie, A., Khoo, W., Fukumoto, M., and Mak, T.W., 1998, High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr. Biol. 8: 1169–1178.PubMedCrossRefGoogle Scholar
  86. Tamir, I., Stlopa, J.C., Helgason, C.D., Nakamura, K., Bruhns, P., Daeron, M., and Cambier, J.C., 2000, The RasGAP-binding protein p62 dok is a mediator of inhibitory FcγRIIb signals in B cells. Immunity, 12: 347–358.PubMedCrossRefGoogle Scholar
  87. Tamura, M., Gu, J., Danen, E.H., Takino, T., Miyamoto, S., Yamada, KM., 1999, PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. J Biol Chem 274: 20693–20703.PubMedGoogle Scholar
  88. Tian, X.X., Pang, J.C., To, S.S., Ng, H.K., 1999, Restoration of wild type PTEN expression leads to apaotosis, induces differentiation, and reduces telomerase activity in human glyoma cells. J. Neuropathol. Exp. Neurol. 58: 472–479.PubMedGoogle Scholar
  89. Tridandapani, S., Kelley, T., Cooney, D., Pradhan, M., and Coggeshall, K.M., 1997, Negative signaling in B cells: SHIP, Grbs, Shc. Immunol. Today, 18: 424–427.PubMedCrossRefGoogle Scholar
  90. Yamanashi Y., Tamura, T., Kanamori, T., Yamane, H., Nariuchi, H., Yamamoto, T., and Baltimore, D., 2000, Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor mediated signaling. Genes and Dev. 14: 11–16.PubMedGoogle Scholar
  91. Vanhaesebroeck, B., Leevers, S.J., Panayotou, G., and Waterfield, M.D., 1997, Phosphoinositide 3-kinases: A conserved family of signal transducers, Trends Biochem. Sci. 22:267–272.PubMedCrossRefGoogle Scholar
  92. Wada T, Sasaoka T, Funaki M, Hori H, Murakami S, Ishiki M, Haruta T, Asano T, Ogawa W, Ishihara H, Kobayashi M. 2001, Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5′-phosphatase catalytic activity. Mol. Cell. Biol. 21: 1633–1646.PubMedCrossRefGoogle Scholar
  93. Wang, J., Koizumi, T., and Watanabe, T., 1996, Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice. J.Exp. Med. 184: 831–838.PubMedGoogle Scholar
  94. Wang, X., Gjörloff-Wingren, A., Saxena, M., Pathan, M., Reed, J.C., and Mustelin, T. 2000. The tumor suppressor PTEN regulates T cell survival and antigen receptor signaling by acting as a phosphatidylinositol 3-phosphatase. J Immunol. 164: 1934–1939.PubMedGoogle Scholar
  95. Wick, W., Furnar, F.B., Naumann. U., Cavenee, W.K., Weller, M. 1999, PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis. Oncogene 18:3936–3943.PubMedCrossRefGoogle Scholar
  96. Wisniewski D, Strife A, Swendeman S, Erdjument-Bromage H, Geromanos S, Kavanaugh WM, Tempst P, Clarkson B., 1999, A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells. Blood, 93: 2707–2720.PubMedGoogle Scholar
  97. Wu, Y., Dowbenko, D., Spencer, S., Laura, R., Lee, J., Gu Q., Lasky L.A. Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase 2000, J. Biol. Chem. 275: 21477–21485PubMedGoogle Scholar
  98. Zhang, X., and Majerus, P.W., 1998, Phosphatidylinositol signaling reactions. Semin. Cell. Dev. Biol. 9. 153–160.PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Gabriella Sarmay
    • 1
  1. 1.Lorand Eotvos UniversityBudapestHungary

Personalised recommendations