Dipeptidyl Peptidase IV Substrates
Many bioactive peptides qualify to be DPPIV substrates. Considering the ubiquitous presence of the enzyme - on cells, on vesicles, in fluids - it is hardly surprising that many of them are indeed found truncated in vivo. However, not all substrates are cleaved with the same efficiency. The molecular properties of DPPIV involved in substrate recognition are still poorly understood.
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