Metallothionein Faciltates Zinc Absorption in Zinc Deficient Mice but Limits Absorption in Zinc Replete Mice

  • P. Coyle
  • J. C. Philcox
  • A. M. Rofe


It is concluded that Zn absorption is enhanced by Zn deficiency and this is in part facilitated by MT. The effect of MT to limit Zn absorption in the Zn replete state but enhance absorption in Zn deficiency appears to result from MT sequestering Zn in the gut and pancreas as well as in the liver. The higher levels of induction of pancreatic and small intestinal MT found in Zn deficient mice may be important to sequestering Zn, limiting its secretion.


Zinc Deficient Mouse Light Halothane Anaesthesia Intestinal Metallothionein 
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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • P. Coyle
    • 1
  • J. C. Philcox
    • 1
  • A. M. Rofe
    • 1
  1. 1.Clinical BiochemistryInstitute of Medical & Veterinary ScienceAdelaideAustralia

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