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Hepatotoxic Effects Associated to Short and Long Term Exposure to Excess Dietary Copper in Rats

  • E. Aburto
  • A. Cribb
  • C. Fuentealba
Chapter
  • 16 Downloads

Keywords

Wilson Disease Indian Childhood Cirrhosis Copper Tolerance Hepatic Copper Copper Toxicosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aston, N., Morris, P., and Tanner, S. 1996, Retrorsine in breast milk influences copper handling in sucking rat pups, J. Hepatol.25:748–755.CrossRefGoogle Scholar
  2. Bradley, C.H. 1993, Copper poisoning in a dairy herd fed a mineral supplement, Can. Vet. J.34:287–292.PubMedPubMedCentralGoogle Scholar
  3. Cooper, G.L., Bickford, A.A., Charlton, B.R., Galey, F.D., Willoughby, D.H., and Grobner, M.A. 1996, Copper poisoning in rabbits associated with acute intravascular hemolysis, J. Vet. Diagn. Invest.8:394–396.CrossRefGoogle Scholar
  4. Fuentealba, I.C. and Bratton, G.R. 1994, The role of the liver, kidney and duodenum in tolerance in the copperloaded rat, Anal. Cell. Pathol.6:345–358.PubMedGoogle Scholar
  5. Haywood, S. 1979, The effect of the sex of weaned rats on the accumulation of dietary copper in their livers, J. Comp. Pathol.89:481–486.CrossRefGoogle Scholar
  6. Haywood, S. 1985, Copper toxicosis and tolerance in the rat. I. Changes in copper content of the liver and kidney, J. Pathol.145:149–158.CrossRefGoogle Scholar
  7. Hoff, B., Boermans, H.J., and Baird, J.D. 1998, Retrospective study of toxic metal analyses requested at a veterinary diagnostic toxicology laboratory in Ontario (1990–1995), Can. Vet. J.39:39–43.PubMedPubMedCentralGoogle Scholar
  8. Kamphues, J., Matschullat, G., and Muller, E. 1991, Copper poisoning of sheep after ad libitum supplementation of rations by a mineral feed, DTW. Dtsch. Tierarztl. Wochenschr.98:109–111.PubMedGoogle Scholar
  9. Kerr, L.A. and McGavin, H.D. 1991, Chronic copper poisoning in sheep grazing pastures fertilized with swine manure, J. Am. Vet. Med. Assoc.198:99–101.PubMedGoogle Scholar
  10. Ludwig, J., Owen, C.A., Barham, S.S., McCall, J.T., and Hardy, R.M. 1980, The liver in the inherited copper disease of Bedlington terriers, Lab. Invest.43:82–87.PubMedGoogle Scholar
  11. Müller, T., Feichtinger, H., Berger, H., and Müller, W. 1996, Endemic Tyrolean infantile cirrhosis: an ecogenetic disorder, Lancet347:877–880.CrossRefGoogle Scholar
  12. Myers, B.M., Prendergast, F.G., Holman, R., Kunts, S.M., and Larusso, N.F. 1993, Alterations in hepatocyte lysosomes in experimental hepatic copper overload in rats, Gastroenterology105:1814–1823.CrossRefGoogle Scholar
  13. Pandit, A. and Bhave, S. 1996, Present interpretation of the role of copper in the Indian childhood cirrhosis, Am. J. Clin. Nutr.63:830S–835S.CrossRefGoogle Scholar
  14. Rui, M. and Suzuki, K.T. 1997, Copper in plasma reflects its status and subsequent toxicity in the liver of LEC rats, Res. Commun. Mol. Pathol. Pharmacol.98:335–345.PubMedGoogle Scholar
  15. Sanz, N., Diez-Fernandez, C., Alvarez, A., and Cascales, M. 1997, Age-dependent modifications in rat hepatocyte antioxidant defense systems, J. Hepatol.27:525–534.CrossRefGoogle Scholar
  16. Scheinberg, I.H. and Sternlieb, I. 1994, Is non-Indian childhood cirrhosis caused by excess dietary copper?, Lancet344:1002–1004.CrossRefGoogle Scholar
  17. Scheinberg, I.H. and Sternlieb, I. 1996, Wilson disease and idiopathic copper toxicosis, Am. J. Clin. Nutr.63:842S–845S.CrossRefGoogle Scholar
  18. Shen, H.M., Shi, C.Y., Lee, H.P., and Ong, C.N. 1994, Aflatoxin B1-induced lipid peroxidation in rat liver, Toxicol. Appl. Pharmacol.127:145–150.CrossRefGoogle Scholar
  19. Sunderman, F.W., Marzouk, A., Hopfer, S., Zahaira, O., and Reid, M. 1985, Increased lipid peroxidation in tissues of nickel chloride-treated rats, Ann. Clin. Lab. Sci.15:229–236.PubMedGoogle Scholar
  20. Sugawara, N., Li, D., Sugawara, C., and Miyake, H. 1995, Response of hepatic function to hepatic copper deposition in rats fed a diet containing copper. Biol. Trace Elem. Res.49:161–169.CrossRefGoogle Scholar
  21. Wu, J., Forbes, J.R., Chen, H.S., and Cox, D.W. 1994, The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene, Nat. Genet.7:541–545.CrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • E. Aburto
    • 1
  • A. Cribb
    • 2
  • C. Fuentealba
    • 1
  1. 1.Department of Pathology and Microbiology Atlantic Veterinary CollegeUniversity of Prince Edward IslandCharlottetownCanada
  2. 2.Department of Anatomy and Physiology Atlantic Veterinary CollegeUniversity of Prince Edward IslandCharlottetownCanada

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