Genomic Structure of Galectin-9 Gene
Elucidation of the genomic structure of the first human electrogenic urate transporting protein will facilitate investigation of its pathogenetic relevance in primary hyperuricemia. Seven missense mutations in 6 exons of galectin-9 gene have been identified so far Their functional consequences remain to be established.
KeywordsGenomic Structure Urate Transport Renal Urate Uric Acid Clearance Renal Uric Acid
Unable to display preview. Download preview PDF.
- 1.Werner, D., Guisan, B, and Roch-Ramel, F, 1991, Urate transport in the proximal tubule of human kidney. Adv Exp Med Biol, 177–180.Google Scholar
- 3.Roch-Ramel, F. and Diezi, J., 1997, Renal transport of organic ions and uric acid. In Diseases of the kidney, (R.W. Schrier, C.W. Gottschalk, eds.), Little Brown, Boston, USA: pp.231–249.Google Scholar
- 5.Spitzenberger, F., Graessler J., and Schroeder H-E., 1999, Molecular characterization of renal ion transport systems — cloning of a putative urate transporter/channel from cultured LLC-PK1 kidney epithelial cells and human kidney. Cell Mol Biol Lett, 4(3): 475–476.Google Scholar
- 8.Graessler, J., Spitzenberger, F., Graessler, A., Parpart, B., Kuhlisch, E., Kopprasch, S., and Schroeder, H-E., 2000, Galectin-9 gene: genomic structure and mutation analysis of a putative human urate channel, submittedGoogle Scholar