The Human NUDT Family of Nucleotide Hydrolases

Enzymes of diverse substrate specificity
  • Alexander G. Mclennan
  • Jared L. Cartwright
  • Lakhdar Gasmi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 486)


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bessman, M.J., Frick, D.N., and O’Handley, S.F., 1996, The MutT proteins or “nudix” hydrolases, a family of versatile, widely distributed, “housecleaning” enzymes. J. Biol. Chem 271: 25059–25062.PubMedGoogle Scholar
  2. 2.
    McLennan, A.G., 1999, The MutT motif family of nucleotide phosphohydrolases in man and human pathogens. Int. J. Mol. Med. 4: 79–89.PubMedGoogle Scholar
  3. 3.
    Fujikawa, K., Kamiya, H., Yakushiji, H., Fujii, Y., Nakabeppu, Y., and Kasai, H., 1999, The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein. J. Biol. Chem. 274: 18201–18205.CrossRefPubMedGoogle Scholar
  4. 4.
    Gasmi, L., Cartwright, J.L. and McLennan, A.G. unpublished dataGoogle Scholar
  5. 5.
    Thorne, N.M.H., Hankin, S., Wilkinson, M.C., Nuñez, C., Barraclough, R. and McLennan, A.G., 1995, Human diadenosine 5′, 5‴-P1, P4-tetraphosphate pyrophosphohydrolase is a member of the MutT family of nucleotide pyrophosphatases, Biochem. J., 311:717–721.PubMedGoogle Scholar
  6. 6.
    McLennan, A.G., 2000, Dinucleoside polyphosphates — friend or foe? Pharmacol. Ther., in press.Google Scholar
  7. 7.
    Safrany, S.T., Ingram, S.W., Cartwright, J.L., Falck, J.R., McLennan, A.G., Barnes, L.D. and Shears, S.B., 1999, The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase — Overlapping substrate specificities in a MutT-type protein. J. Biol. Chem. 274: 21735–21740.CrossRefPubMedGoogle Scholar
  8. 8.
    Caffrey, J. J., Safrany, S.T., Yang, X., and Shears, S.B., 2000, Discovery of molecular and catalytic diversity among human diphosphoinositol polyphosphate phosphohydrolases: an expanding NUDT family. J. Biol. Chem. 275: 12730–12736.PubMedGoogle Scholar
  9. 9.
    Gasmi, L., Cartwright, J.L., and McLennan, A.G., 1999, Cloning, expression and characterization of YSA1H, a human adenosine 5′-diphosphosugar pyrophosphatase possessing a MutT motif. Biochem. J. 344: 331–337.CrossRefPubMedGoogle Scholar
  10. 10.
    Murphy, P.R., and Knee, R.S., 1994, Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene. Mol. Endocrinol. 8: 852–859.CrossRefPubMedGoogle Scholar
  11. 11.
    Frick, D.N., and Bessman, M.J., 1995, Cloning, purification, and properties of a novel NADH pyrophosphatase — Evidence for a nucleotide pyrophosphatase catalytic domain in MutT-like enzymes. J. Biol. Chem. 270: 1529–1534.PubMedGoogle Scholar
  12. 12.
    Gaudon, C., Chambon, P., and Losson, R., 1999, Role of the essential yeast protein PSU1 in transcriptional enhancement by the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J. 18: 2229–2240.CrossRefPubMedGoogle Scholar
  13. 13.
    Dunckley, T., and Parker, R., 1999, The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif. EMBO J. 18: 541l–5422.CrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Alexander G. Mclennan
    • 1
  • Jared L. Cartwright
    • 1
  • Lakhdar Gasmi
    • 1
  1. 1.School of Biological SciencesUniversity of LiverpoolLiverpoolUK

Personalised recommendations