Taurine 4 pp 35-44 | Cite as

Mode of Action of Taurine and Regulation Dynamics of Its Synthesis in the CNS

  • Jang-Yen Wu
  • Weiqing Chen
  • Xiao Wen Tang
  • Hong Jin
  • Todd Foos
  • John V. Schloss
  • Kathleen Davis
  • Morris D. Faiman
  • Che-Chang Hsu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 483)

Conclusion

The regulation of taurine biosynthesis can be summarized as following: (i) When neurons are stimulated, the arrival of action potential will open the voltage-dependent Ca2+-channel, resulting in an increase of intracellular free Ca2+, [Ca2+]i, (ii) Elevation of [Ca2+]i will trigger release of taurine as well as activation of PKC, which in turn activates CSAD through protein phosphorylation; (iii) The activated CSAD then synthesizes more taurine to replenish that lost due to stimulation-mediated release; (iv) When intracellular taurine reach a certain level, it then inhibits the activation of PKC directly or indirectly (possibly through regulating Ca2+ availability), thus shutting down activation of CSAD through inhibition of CSAD phosphorylation by PKC; and (v) CSAD soon returns to its inactive state through the action of a protein phosphatase, most likely PrP-2C. The mode of action of taurine inlowering the level of [Ca2+]i, is at least partially due to its inhibition on the reverse mode of Na+-Ca2+ exchanger activity

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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Jang-Yen Wu
    • 1
    • 2
  • Weiqing Chen
    • 1
  • Xiao Wen Tang
    • 1
  • Hong Jin
    • 1
  • Todd Foos
    • 1
  • John V. Schloss
    • 3
  • Kathleen Davis
    • 1
  • Morris D. Faiman
    • 4
  • Che-Chang Hsu
    • 1
  1. 1.Dept. of Mol. Biosci.Univ. of KansasLawrenceUSA
  2. 2.Inst. ofBiol. Chem.Academia SinicaTaipeiTaiwan
  3. 3.Dept. of Med. Chem.Univ. of KansasLawrenceUSA
  4. 4.Dept. of Pharmacol. & Toxicol.Univ. of KansasLawrenceUSA

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