Chromogranins: Current Concepts

Structural and Functional Aspects
  • Dominique Aunis
  • Marie-Hélène Metz-Boutigue
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 482)

Conclusion

Although a large amount of work has been carried out since the discovery of the first chromogranin more than thirty years ago, many questions have yet to be answered. The structure, expression and localization of the chromogranin/secretogranin proteins are now well established. However, the crucial questions concern the biological function of these proteins and/or the peptides derived from them.

As an example vasostatin-I represent a multifacet component since a variety of different properties seem to be associated to this peptide. Therefore, the true challenge for the next years is to define the specific receptors on target cells and to understand how the peptide penetrates and kills bacteria and fungi. What could be the membrane interacting domains involved in sorting and aggregation, is also an important question to address, for the vasostatins and all granin-derived peptides that are generated in endocrine cells and neurons.

New vistas concern the role of CG-derived peptides in the neuroimmune field. The recent findings converge to point out major functions, opening the field and serving as challenges for future investigations.

Keywords

Secretory Granule Chromaffin Cell Adrenal Medulla Chromaffin Granule Glycan Moiety 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Dominique Aunis
    • 1
  • Marie-Hélène Metz-Boutigue
    • 1
  1. 1.Unité Biologie de la Communication Cullulaire, INSERM U-338StrasbourgFrance

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