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Tumor-Targeted Salmonella

Highly Selective Delivery Vectors
  • David Bermudes
  • Brooks Low
  • John Pawelek
Chapter
First Online:
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 465)

Summary

Genetically engineered Salmonella offer an intriguing new approach to selectively target solid tumors, including melanoma, lung, colon, breast, kidney and liver. These bacteria target tumors after systemic administration and selectively replicate within them. Specificity for tumors is often more than 1,000 times greater than for any other tissue. Auxotrophic mutations make these bacteria highly safe and form the basis for maintaining tumor specificity. An altered lipid greatly reduces the potential for septic shock yet also retains the antitumor properties of these bacteria. These bacteria have innate antitumor activity towards both primary and metastatic tumors and the ability to deliver proteins capable of activating chemotherapeutic agents directly within tumors. The delay in tumor growth results in mice that survive up to twice as long. These bacteria are susceptible to a wide range of antibiotics, allowing external control of the vector after administration. The combination of these features within a single vector seems especially surprising considering their unlikely source.

Keywords

Thymidine Kinase Cancer Gene Therapy Inhibit Tumor Metastasis Stealth Liposome Amino Acid Auxotrophy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • David Bermudes
    • 1
  • Brooks Low
    • 2
  • John Pawelek
    • 3
  1. 1.Vion Pharmaceuticals, Inc.New HavenUSA
  2. 2.Department of Therapeutic RadiologyYale University School of MedicineNew HavenUSA
  3. 3.Department of Therapeutic DermatologyYale University School of MedicineNew HavenUSA

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