Apoptin®

  • Alexandra Pietersen
  • Mathieu H. M. Noteborn
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 465)

Summary

Tumor cells are often characterized by the traithey are more resistant to apoptosis induced by e.g. cytotoxic agents than normal cells. Resistance to apoptosis induction can be a direct consequence of mutations in certain tumor-suppressor genes (p53) or of certain proto-oncogenes (Bcl-2). Therefore, new cancer therapies are under development to bypass the resistance to chemo- and radio-therapy of tumors. Apoptin acts independently of p53, is stimulated by Bcl-2 and is insensitive to BCR-ABL, which means that Apoptin can induce apoptosis in cases where present (chemo)-therapeutic agents, unfortunately, will fail. The fact that Apoptin induces apoptosis in human tumorigenic cells but not in normal diploid cells, implies that side-effects of Apoptin treatment are expected to be minor. In-vivo results with a first prototype of anti-tumor therapy based on expression of Apoptin indicate that Apoptin has low acute toxicity and is effective as an anti-tumor agent.

Keywords

Cancer Gene Therapy Chicken Anemia Virus Tumorigenic Cell Line Normal Diploid Cell Osteosarcoma Cell Line U2OS 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Alexandra Pietersen
    • 1
  • Mathieu H. M. Noteborn
    • 1
  1. 1.Leadd BV, and Apoptin Group Department of Molecular Cell BiologyLeiden University Medical CenterLeidenThe Netherlands

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