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Adhesion Molecules in Cancer Biology

  • Yaw Ohene-Abuakwa
  • Massimo Pignatelli
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 465)

Keywords

Cell Adhesion Molecule Colon Carcinoma Cell Line Colorectal Carcinoma Cell Line Lymphocyte Homing CD44v Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Referencen

  1. Agrez, M.V., and Bales, R.C., 1994, Colorectal cancer and the integrin family of cell adhesion receptors: current status and future directions, Euro. J. Cancer, 30A, 2166–2170.Google Scholar
  2. Akiyama, S.K., Larjava, H., and Yamada, K.M., 1990, Differences in the biosynthesis and differentiation of the fibronectin receptor in normal and transformed cultured human cells, Cancer Res., 50, 1601–1607.PubMedGoogle Scholar
  3. Albelda, S.A., and Buck, C.A., 1990, Integrins and other cell adhesion molecules, FASEB J., 4, 2868–2880.PubMedGoogle Scholar
  4. Albelda, S.M., 1991, Endothelial and epithelial cell adhesion molecules, Am J Resp Cell Biol., 4, 195–203.Google Scholar
  5. Albelda, S.M., 1993, Role of Integrins and other cell adhesion molecules in tumour progression and metastasis, Laboratory Investigation 68, 4–17.PubMedGoogle Scholar
  6. Albelda, S.M., Mette, S.A., and Elder, D.E., 1990, Integrin distribution in malignant melanoma: Association of the β3 subunit with tumour progression, Cancer Res., 50, 6757–6764.PubMedGoogle Scholar
  7. Ansari, T., Lemoine, N., Gunter, P., Liu, D., Hirano, S., Takeichi, M., Kloppel, G., and Pignatelli, M., 1994, Decreased E-cadherin expression correlates with lymph node metastasis, high grade and advanced stage in pancreatic cancer, J. Pathol., 172, A12.Google Scholar
  8. Aruffo, A., Stamenkovic, I., Melnick, M., Underhill, C.B., and Seed, B., 1990, CD44 is the principal cell surface receptor for hyaluronate, Cell, 61, 1303–1313.PubMedCrossRefGoogle Scholar
  9. Basora, N., Desloges, N., Chang, Q., Bouatrouss, Y., Gosselin, J., Poisson, J., Sheppard, D., and Beaulieu, J.-F, 1998, Expression of the α9β1 integrin in human colonic epithelial cells: Resurgence of the foetal phenotype in a subset of colonic cancers and adenocarcinoma cell lines, Int. J. Cancer, 75, 738–743.PubMedCrossRefGoogle Scholar
  10. Barlolazzi, A., Peach, R., Aruffo, A., and Stamenkovic, I., 1994, Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumour development, J. Exp. Med., 180, 53–66.Google Scholar
  11. Beckner, M.E., Krutzsch, H.C., Stracke, M.L., Williams, S.T., Gallardo, J.A., and Liotta, L.A., 1995, Identification of a new immunoglobulin superfamily protein expression in blood vessels with a heparin-binding consensus sequence, Cancer Res., 55, 2140–2149.PubMedGoogle Scholar
  12. Birch, M., Mitchell, S., and Hart, I.R., 1991, Isolation and characterisation of human melanoma cell variants expression high and low levels of CD44, Cancer Res., 51, 6660–6667.PubMedGoogle Scholar
  13. Bonkhoff, H., Stein, U., and Remberger, K., 1993, Differential expression of α6 and α2 very late antigen inte-grins in the normal hyperplastic and neoplastic prostate. Hum. Pathol., 24, 243–248.PubMedCrossRefGoogle Scholar
  14. Bringuier, P.P., Umbas, R., Schaafsma, H.W., Karthaus, H.F.M., Debruyne, F.M.J., and Schaken, J.A., 1993, Decreased E-cadherin immunoreactivity correlates with poor survival in patients with bladder tumours, Cancer Res., 53, 3241–3245.PubMedGoogle Scholar
  15. Cannistra, S.A., Kansas, G.S., Niloff, J., DeFranzo, B., Kim, Y., and Ottensmeier, C., 1993. Binding of ovarian cancer cells to peritoneal mesothelium in vitro is partly mediated by CD44H, Cancer Res., 53, 3830–3838.PubMedGoogle Scholar
  16. Carter, B.S., Eing, C.M., Ward, W.S., Treiger, B.F., Aalders, T.W., Schalken, J.A., Epstein, J.I., and Isaacs, W.B., 1990, Allelic loss of chromosome I6q and l0q in human prostate cancer, Prco. Natl. Acad. Sci., 87, 8751–8755.Google Scholar
  17. Chan, B.M., 1991, In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells, Science. 251, 1600–1602.PubMedGoogle Scholar
  18. Davies, B.R., Worsley, S.D., and Ponder, B.A., 1998, Expression of E-cadherin, α-catenin and β-catenin in normal ovarian surface epithelial and epithelial ovarian cancer, Histopathology, 32, 69–80.PubMedCrossRefGoogle Scholar
  19. De La Coste, A., Romagnolo, B., Billuart, P., Renard, C.-A., Buendia, M.-A., Soubrane, O., Fabre, M., Chelly, J., Beldjord, C., Khan, A., and Perret, C., 1998, Somatic mutation of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas, Proc. Natl. Acad. Sci. USA, 95, 8847–8851.CrossRefGoogle Scholar
  20. Edelman, G.M., and Crossin, K.L., 1991, Cell adhesion molecules: implications for molecular histology, Annu. Rev. Biochem., 60, 155–190.PubMedCrossRefGoogle Scholar
  21. Elices, M.J., Osborn, L., Takada, Y., et al., 1990, VCAM-1 on activated endothelium interacts with the leukocytes integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell, 60, 577–584.PubMedCrossRefGoogle Scholar
  22. Falconi, R., Sacchi, A., Reseau, J., and Kennel, S.J., 1988, Monoclonal antibody to human carcinoma-associated protein complex: quantitation in normal and tumour tissue, Cancer Res., 48, 816–821.Google Scholar
  23. Fearon, E.R., Cho, K.R., Nigro, J.M., Kern, S.E., Simmons, J.W., Ruppert, J.M., Hamilton. S.R., Preisinger, A.C., Thomas, G., Kinzler, K.W., and Volgestein, B., 1990, Identification of chromosome 18q gene that is altered in colorectal cancers, Science, 247, 49–56.PubMedGoogle Scholar
  24. Frisch, S.M., and Ruoslahti, E., 1997, Integrins and anoikis, Curr. Opin. in Cell Biol., 9, 701–706.Google Scholar
  25. Garin-Chesa, P., Fellinger, E.J., Huvos, A.G., Beresford, H.R., Melamed, M.R., Triche, T.J., and Rettig, W.J.. 1991, Immunohistochemical analysis of neural cell adhesion molecules, Am. J. Pathol., 139, 275–286.PubMedGoogle Scholar
  26. Giancotti, F.G., and Ruoslahti, E., 1990, Elevated levels of the α5β1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells, Cell, 60, 849–859.PubMedCrossRefGoogle Scholar
  27. Gui, G.P.H., Puddefoot, J.R., Vinson, G.P., Wells, C.A., and Carpenter, R., 1997, Altered cell-matrix contact: a prerequisite for breast cancer metastasis? Br. J. Cancer, 75, 623–633PubMedGoogle Scholar
  28. Gumbiner, B.M., and McCrea, P.D., 1993, Catenins as mediators of the cytoplasmic functions of cadherins, J. Cell Sci. Suppl, 17, 155–158.PubMedGoogle Scholar
  29. Gunthert, U., Hofmann, M., Rudy, W., Reber, S., Zoller, M., Haubmann, I., Matzku, S., Wenbel, A., Ponta, H., and Herrlich, A., 1991, A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells, Cell, 65, 13–24.PubMedCrossRefGoogle Scholar
  30. Hall, P.A., Coates, P., Lemoine, N.R., and Horton, M.A., 1991, Characterisation of integrin chains in normal and neoplastic human pancreas, J. Pathol., 165, 33–41.PubMedGoogle Scholar
  31. Hatta, K., and Takeichi, M., 1987, Expression of N-cadherin adhesion molecules associated with early morphogenic events in chick development, Nature, 320, 447–449.Google Scholar
  32. Hedrick, L., Cho, K.R., and Volgelstein, B., 1995, Cell adhesion molecules as tumour suppressors, Trends Cell Biol., 3, 36–39.Google Scholar
  33. Heino, J., 1996, Biology of tumour cell invasion: interplay of cell adhesion and matrix degradation, Int. J. Cancer, 65, 717–722.PubMedCrossRefGoogle Scholar
  34. Helmer, M.E., 1990, VLA proteins in the integrin family: Structures, functions and their role on leukocytes, Annu. Rev. Immunol., 8, 549–555.Google Scholar
  35. Hermiston, M.L., and Gordon, J.I., 1995, In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation and regulation of programme cell death, J. Cell Biol., 129, 489–506.PubMedCrossRefGoogle Scholar
  36. Hiraguri, S., Godfrey, T., Nakamura, H., Graff, J., Collins, C., Shayesteh, L., Doggett, N., Johnson, K., Wheelock, M., Herman, J., Baylin, S., Pinkel, D., and Gray, J., 1998, Mecahinsm of inactivation of E-cadherin in breast cancer cell lines, Cancer Res., 58, 1972–1977.PubMedGoogle Scholar
  37. Hiroshashi, S., 1998, Inactivation of the E-cadherin mediated cell adhesion system in human cancers, Am. J. Pathol., 153, 333–339.Google Scholar
  38. Hofmann, M., Rudy, W., Zoller, M., Tolf, C., Ponta, H., Herrlich, P., and Gunthert, U., 1991, CD44 splice variant confer metastatic behaviour in rats: Homologous sequences are expressed in human tumour cell lines, Cancer Res., 51, 5292–5297.PubMedGoogle Scholar
  39. Hohne, M.W., Halatsch, M.E., Kahl, G.F., and Weinel, R.J., 1992, Frequent loss of expression of potential tumour suppressor gene DCC in ductal pancreatic adenocarcinoma, Cancer Res., 52, 2616–2619.PubMedGoogle Scholar
  40. Hong, S., Santoro, S.A., and Zutter, M.M., 1998, Downstream events in mammary gland morphogenesis mediated by re-expression of the α2β1 integrin: The role of α6 and β4 integrin subunits, Cancer Res., 58, 2224–2233.Google Scholar
  41. Howe, A., Aplin, A.E., Alahari, S.K., and Juliano, R.L., 1998, Integrin signaling and cell growth control, Curr. Opin. in Cell Biol., 10, 220–231.Google Scholar
  42. Hynes, R.O., 1992, Integrins: versatility, modulation and signalling in cell adhesion, Cell, 69, 11–25.PubMedCrossRefGoogle Scholar
  43. Hynes, R.O., and Lander, A.D., 1992, Contact and adhesive specificity in the association, migration and targeting of cells and axons, Cell, 68, 303–322.PubMedCrossRefGoogle Scholar
  44. Imai, Y., Lasky, L.A., and Rosen, S.D., 1992, Further characterisation of the interaction between L-selectin and its endothelial ligands, Glycobiology, 2, 373–381.PubMedGoogle Scholar
  45. Jalkenan, S., Joensuu, H., Soderstorm, K.O., and Klemi, P.J., 1991, Lymphocyte homing and clinical behaviour of non-Hodgkin’s lymphom, J. Clin. Invest., 87, 1835–1840.Google Scholar
  46. Joensuu, H., Klemi, P.J., Toikkanen, S., and Jalkenan, S., 1993, Glycoprotein CD44 expression and its association with survival in breast cancer, Am. J. Pathol., 143, 867–874.PubMedGoogle Scholar
  47. Johnson, J.P., Stade, B.G., Holzmann, B., Schwable, W., and Riethmuller, G., 1989, De novo expresion of intercellular-adhesion molecule in melanoma correlates with increased risk of metastasis, Proc. Natl. Acad. Sci. USA, 86, 641–644.PubMedGoogle Scholar
  48. Jones, J.L., Royall, J.E., Critchley, D.R., and Walker, R.A., 1997, Modulation of myoepithelial-associated α6β4 integrin in a breast cancer cell line alters invasive potential, Expt. Cell Res., 235, 325–333.CrossRefGoogle Scholar
  49. Jothy, S., Yuan, S.-Y, and Shirota, K., 1993, Transcription of carcinoembryonic antigen in normal colon and colon carcinoma: in situ hybridisation study and the implication for a new in vivo functional model, Am. J. Pathol., 143, 250–257.PubMedGoogle Scholar
  50. Kennel, S.J., Foote, L.J., Falconi, R., Sonnenberg, A., Crouse, C., and Helmer, M.E., 1989, Analysis of the tumour associated antigen TSP-180: identity with α6β4 in the integrin superfamily, J. Biol., Chem., 264, 15515–15521.Google Scholar
  51. Korman, N.J., and Hrabovsky, S.L., 1993, basal cell carcinomadisplay extensive abnormalities in the hemidesmosome anchoring fibril complex, Exp. Dematol., 2, 139–144.Google Scholar
  52. Koukoulis, G.K., Virtanen, I., Moll, R., Quaranta, V., and Gould, V.E., 1993, Immunolocalisation of integrins in the normal and neoplastic colonic epithelium, Virchows Archiv. B. Cell Pathol., 63, 373–383.CrossRefGoogle Scholar
  53. Landuzzi, L., Frabetti, F., Rossi, I., Griffoni, C., De Giovanni, C., Nicoletti, G., Nanni, P., Miniero, R., Palmieri, G., Santoni, A., and Lollini, P.-L., 1996, Expression of transduced carcinoembryonic antigen gene in human rhabdomyosarcoma inhibits metastasis, Cancer Res., 56, 4503–4508.PubMedGoogle Scholar
  54. Lauri, D., Needham, L., Martin-Padura, I., and Dejana, E., 1991, Tumour cell adhesion to endothelial cells: Endothelial leukocyte adhesion molecule-1 as an inducible adhesive receptor specific for colon carcinoma cells, J. Natl. Cancer Inst., 83, 1321–1324.PubMedGoogle Scholar
  55. Li, H., Hamou, M., Tibolet, N., Jaufeerally, R., Hofmann, M., Diserens, A., and Van Meir, E.G., 1993, Variant CD44 adhesion molecules are expressed in human brain metastases but not in glioblastomas, Cancer Res., 53, 5345–5349.PubMedGoogle Scholar
  56. Liebert, M., Washington, R., Wedemeyer, G., et al., 1994, Loss of co-localisation of α6β4 integrin VII in bladder cancer, Am. J. Pathol., 144, 787–795.PubMedGoogle Scholar
  57. Liu, D., Gagliardi, G., Nasim, M.M., et al., 1994, Transforming growth factor alpha can act as morphogen and/or mitogen in colorectal carcinoma cell line, Int. J. Cancer, 56, 603–608.PubMedGoogle Scholar
  58. Lotz, M.L., Korzelius, C.A., and Mercurio, A.M., 1990, Human colon carcinoma cells use multiple receptors to adhere to laminin: involvement of α6β4 and α2β1 integrins, Cell Regul., 1, 249–257.PubMedGoogle Scholar
  59. Manie, S.N., Astier, A., Haghayeghi, N., Canty, T., Druker, B.J., Hirai, H., and Freedman, A.S.,1997, Regulation of integrin-mediated p130 cas Tyrosine phosphorylation in human B cells, J. Biol. Chem., 272, 15636–15641.Google Scholar
  60. Marchisio, P.C., Cremona, O., Savoia, P., et al., 1993, The basement membrane protein BM-600/nicein codistributes with kalinin and the integrin α6β4 in human cultured keratinocytes, Exp. Cell Res., 205, 205–212.PubMedCrossRefGoogle Scholar
  61. Matsamura, Y., and Tarin, D., 1992. Significance of CD44gene products for cancer diagnosis and disease evaluation, Lancet, 340, 1053–1058.Google Scholar
  62. Matsushita, Y., Cleary, K.R., Ota, D.A., Hoff, S.D., and Irimura, T., 1990, Sialyldomeric lewis-X antigen expressed on mucin-like glycoprotein in colorectal cancer matastases, Lab. Invest., 63, 780–791.PubMedGoogle Scholar
  63. Mayer, B., Johnson, J.P., Leitl, F., Jauch, K.W., Heiss, M.M., Schilberg, F.W., Birchmeier, W., and Funke, I., 1993, E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration, Cancer Res., 53, 1690–1695.PubMedGoogle Scholar
  64. Nigam, A.K., Pignatelli, M., and Boulos, P.B., 1994, Current concepts in metastasis, Gut, 35, 996–1000. Nigam, A.K., Savage, F.J., Boulos, P.S., Stamp, G.W.H., Liu, D., and Pignatelli, M., 1993, Loss of cell-cell andPubMedGoogle Scholar
  65. Nigam, A.K., Savage, F.J., Boulos, P.S., Stam, G.W.H., Liu, D., and Pignelli, M.,1993, Loss of cell-cell an cell-matrix adhesion molecules in colorectal cancer, Br. J. Cancer, 68, 507–514.Google Scholar
  66. Oyama, T., Kanai, Y, Ochiai, A., Akimoto, S., Oda, T., Yanagihara, K., Nagafuchi, A., Tsukita, S., Shibamoto, S., Ito, F., Takeichi, M., Matsuda, H., and Hirohashi, S., 1994, A truncated β-catenin disrupts the interaction between E-cadherin and α-catenin Acause of loss of intercellular adhesiveness in human cancer cell lines, Cancer Res., 54, 6282–6287.PubMedGoogle Scholar
  67. Paget, S., 1989, The distribution of secondary growths in cancer of the breast, Lancet, 1, 571–573.Google Scholar
  68. Paul, R., Ewing, C.M., Jarrard, D.F., and Isaacs, W.B., 1998, Mechanisms of inactivation of the cadherin-catenin pathway include LOH, gene deletion and gene promoter hypermethylation, Br. J. Urol. Suppl, 1, 37–43.Google Scholar
  69. Pignatelli, M., 1993, E-cadherin: a biological marker of tumour differentiation, J. Pathol., 171, 81–82.PubMedCrossRefGoogle Scholar
  70. Pignatelli, M., and Bodmer, W.F., 1988, Genetics and biochemistry of collagen binding triggered glandular differentiation in human colon carcinoma cell lines, Proc. Natl. Acad. Sci. USA, 85, 5561–5565.PubMedGoogle Scholar
  71. Pignatelli, M., and Bodmer, W.F., 1990, Integrin cell adhesion molecules in colorectal cancer, J. Pathol., 162, 95–97.PubMedCrossRefGoogle Scholar
  72. Pignatelli, M., Durbin, H., and Bodmer, W.F., 1990a, Carcinoembryonic antigen functions as an accessory adhesion molecule mediating colon epithelial cell-collagen interactions, Proc. Natl. Acad. Sci. USA, 87, 1541–1545.Google Scholar
  73. Pignatelli, M., Hanby, A.M., and Stamp, G.W.H., 1991, Low expression of β1, α2 and α3 subunits of VLA integrins in malignant mammary tumours, J. Pathol., 165, 25–32.PubMedCrossRefGoogle Scholar
  74. Pignatelli, M., Smith, M.E.F., and Bodmer, W.F., 1990b, Low expression of collagen receptors in moderate and poorly differentiated colorectal adenocarcinomas, Br. J. Cancer, 61, 636–638.PubMedGoogle Scholar
  75. Ruoslahti, E., and Reed, J., 1994, Anchorage independence, integrins and apoptosis, Cell, 77, 477–478.PubMedCrossRefGoogle Scholar
  76. Sato, T., Akiyama, F., Sakamoto, G., Kasumi, F., and Nakamura, Y., 1991, Accumulation of genetic alterations and progression of primary breast cancer, Cancer Res., 51, 5794–5799.PubMedGoogle Scholar
  77. Schipper, J.H., Frixen, U.H., Behrens, J., Unger, A., Jahnke, K., and Birchmeier, W., 1991, E-cadherin expression in squamous cell carcinomas of the head and neck: inverse correlation with tumour dedifferentiation and lymph node metastasis, Cancer Res., 51,6328–6337.PubMedGoogle Scholar
  78. Slagle, B.L., Zhou, Y.-Z., Birchmeier, W., Scorsone, K.A., 1993, Deletion of the E-cadherin gene in hepatitis virus-posirive Chinese hepatocellular carcinomas, Hepatology, 18, 757–762.PubMedGoogle Scholar
  79. Sleeg, P., Bevilacqua, G., Sobel, M., and Liotta, L., 1994, Invasion and metastasis in: molecular genetics in cancer diagnosis, pp 49–53, Ed., Jeffrey Cossman, Elsevier.Google Scholar
  80. Soler, A.P., Harner, G.D., Knudsen, K.A., McBrearty, F.X., Grujic, E., Salazar, H., Han, A.C., and Keshgegian, A.A., 1997, Expression of P-cadherin identifies prostate specific-antigen-negative cells in epithelial tissues of male sexual accessory organs and in prostatic carcinomas, Am. J. Path., 151, 471–478.PubMedGoogle Scholar
  81. Soler, A.P., Knudsen, K.A., Tecson-Miguel, A., McBrearty, F.X., Han, A.C., Salazar, H., 1995, The differential expression of N-cadherin and E-cadherin distinguishes pleural mesotheliomas from lung adeno-carcinomas, Hum. Path., 26, 1363–1369.Google Scholar
  82. Springer, T.A., 1990, Adhesion receptors of the immune system, Nature, 346, 425–435.PubMedCrossRefGoogle Scholar
  83. St. Croix, B., Sheehan, C., Rak, J.W., Florense, V.A., Slingerland, J.M., and Kerbel, R.S., 1998, E-cadherin-dependent growth suppression is mediated by cyclin-dependent kinase inhibitor p27KJP J. Cell Biol., 142, 557–571.PubMedCrossRefGoogle Scholar
  84. Stamenkovic, I., Amiot, M., Pesando, J.M., and Seed, B., 1989, A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family, Cell, 56, 1057–1062.PubMedCrossRefGoogle Scholar
  85. Stamenkovic, I., Aruffo, A., Amiot, M., and Seed, B., 1991, The hematopoietic and epithelial forms of CD44 are distinct polypeptydes with different adhesion potentials for hyaluronate bearing cells, EMBO J., 10, 343–348.PubMedGoogle Scholar
  86. Stamp, G.W.H., and Pignatelli, M., 1991, Distribution of β1, α1, α2 and α3 integrin chain in basal cell carcinomas, J. Pathol., 163, 307–313.PubMedCrossRefGoogle Scholar
  87. Tuszynski, G.P., Wang, T.N., and Berger, D., 1997, Adhesive protein and the hematogenous spread of cancer, Acta Haematologica, 97, 29–39.PubMedCrossRefGoogle Scholar
  88. Valizadeh, A., Karayiannakis, A.J., El-Hariry, I., Kimot, W., and Pignatelli, M., 1997, Expression of E-cadherin-associated molecules (α-,β- and γ-catenins and p120) in colorectal polyps, Am. J-Path., 150, 1977–1984.PubMedGoogle Scholar
  89. Varner, J.A., and Cheresh, D.A., 1996, Integrins and cancer, Curr Opin in Cell Biol., 8, 742–730.Google Scholar
  90. Vessey, C.J., Wilding, J., Folarin, N., Hirano, S., Takeichi, M., Soutter, P., Stamp, G.W.H., and Pignatelli, M., 1995, Altered expression and function of E-cadherin in cervical intraepithelial neoplasia and invasive squamous cell carcinoma, J. Pathol., 176, 151–159PubMedCrossRefGoogle Scholar
  91. Wielenga, V.J.M., Heider, K.-H., Offerhaus, G.J.A., Adolf, G.R., van der Berg, F.M., Ponta, H., Herrlick, P., and Pals, S.T., 1993, Expression of CD44 variant protein in human colorectal cancer is related to tumour progression, Cancer Res., 53, 4754–4756.PubMedGoogle Scholar
  92. Wu, S.Q., Storer, B.E., Bookland, E.A., et al., 1991, Nonrandom chromosome losses in stepwise neoplastic transformation in vitro of human uroepithelial cells, Cancer Res., 51, 3323–3326.PubMedGoogle Scholar
  93. Yap, A.S., Niessen, C.M., and Gumbiner, B.M., 1998, The juxtamembrane region of the cadherin cytoplasmic tail support lateral clustering, adhesive strengthening, and interaction with p120 cin J. Cell Biol., 141, 779–789.PubMedCrossRefGoogle Scholar
  94. Zutter, M.M., Krigman, H.R., and Santoro, S.A., 1993, Altered integrin expression in adenocarcinoma of the breast,Am. J. Pathol., 142, 1439–1448.PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Yaw Ohene-Abuakwa
    • 1
  • Massimo Pignatelli
    • 1
  1. 1.Division of Investigative ScienceImperial College School of MedicineLondon

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