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Oxidative Stress in Obstructive and Restrictive Lung Diseases

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Abstract

The lung has ample and vascularized surface area constantly exposed to endogenous and environmental oxidants (in particular cigarette smoke). Thus, the imbalance between oxidants and antioxidant defenses has a pathologically important role in several lung disorders. This chapter describes the sources of free radical generation, ROS-induced signaling pathways, and mechanisms of oxidative stress damages in the pathogenesis of obstructive pulmonary diseases, idiopathic pulmonary fibrosis, and asthma. ROS are regulatory factors in different molecular pathways involved in miscellaneous lung diseases and might represent potential suggestions for therapeutic approaches. Given the limited effectiveness of current strategies, novel experimental approaches to develop improved antioxidant therapies are discussed.

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Conflict of Interest

The authors declare no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy

    Elena Bargagli

  2. Hannover Medical School, Hannover University, Hannover, Germany

    Alfonso Carleo

Authors
  1. Elena Bargagli
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  2. Alfonso Carleo
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Corresponding author

Correspondence to Elena Bargagli .

Editor information

Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Department of Internal Medicine, The Ohio State University, Columbus, OH, USA

    Narasimham L. Parinandi

  3. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Rita Ghosh

  4. Apollo Hospitals Educational & Research Foundation (AHERF), Indraprastha Apollo Hospitals, New Delhi, Delhi, India

    Nirmal K. Ganguly

  5. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Tapati Chakraborti

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Bargagli, E., Carleo, A. (2020). Oxidative Stress in Obstructive and Restrictive Lung Diseases. In: Chakraborti, S., Parinandi, N., Ghosh, R., Ganguly, N., Chakraborti, T. (eds) Oxidative Stress in Lung Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-32-9366-3_9

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