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Mature B-Cell Acute Lymphoblastic Leukemia

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Pediatric Acute Lymphoblastic Leukemia

Abstract

Mature B-cell acute lymphoblastic leukemia (ALL), which is known as Burkitt leukemia, is included in Burkitt lymphoma according to the WHO classification. Approximately 80% of mature B-cell ALL is associated with t(8;14)(q24;q32). The Lymphoma Malignancy B and Berlin–Frankfurt–Munster studies have showed that intensive multiagent chemotherapy improves the outcome of mature B-cell ALL, and that the long-term event-free survival rate of advanced stage mature B-cell non-Hodgkin lymphoma (B-NHL), including mature B-cell leukemia, is 80–85%. However, the prognosis of relapsed or refractory B-NHL is poor. The short-term overall survival of patients with relapsed or refractory B-NHL has been reported to be approximately 20–30%, even though hematopoietic stem cell transplantation has been adopted. The efficacy of rituximab, an anti-CD20 antibody, has been established for adults with B-NHL. Recently, the safety and efficacy of rituximab for pediatric B-NHL has also been reported. Thus, it is expected that rituximab combined with chemotherapy will be established as the standard treatment for high-risk pediatric patients with B-NHL as well as for adults with B-NHL, and this therapy is believed to improve the outcome of mature B-cell leukemia.

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Authors and Affiliations

  1. Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan

    Reiji Fukano

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  1. Reiji Fukano
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Correspondence to Reiji Fukano .

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Editors and Affiliations

  1. Department of Transplantation and Cell Therapy, Children’s Cancer, Center National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan

    Motohiro Kato

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Fukano, R. (2020). Mature B-Cell Acute Lymphoblastic Leukemia. In: Kato, M. (eds) Pediatric Acute Lymphoblastic Leukemia. Springer, Singapore. https://doi.org/10.1007/978-981-15-0548-5_8

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  • DOI: https://doi.org/10.1007/978-981-15-0548-5_8

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  • Publisher Name: Springer, Singapore

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  • Online ISBN: 978-981-15-0548-5

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