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Gold Nanostructures in Medicine and Biology

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Abstract

Gold nanostructures with their unique properties (tunable surface chemistry, morphology, optical, and electronic properties) can be applied for a wide range of biological and medical applications. By using size- or shape-controlled preparation, specific surface modifications, and molecular targeting, it appears that the properties of gold nanostructures can be optimized for specific applications. Gold nanostructures are stable and relatively inert in bio-systems, leading to low reactogenicity, high biocompatibility, and general lack of toxicity. They can be applied for detection, diagnosis, and treatment of some diseases like cancers. In this chapter, some important applications of gold nanostructures including diagnostics (imaging), gene delivery/therapy, drug delivery, and cancer diagnosis/therapy are highlighted.

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References

  • Abadeer NS, Murphy CJ. Recent progress in cancer thermal therapy using gold nanoparticles. J Phys Chem C. 2016;120:4691–716.

    Article  CAS  Google Scholar 

  • Bhana S, Lin G, Wang L, Starring H, Mishra SR, Liu G, Huang X. Near-infrared-absorbing gold nanopopcorns with iron oxide cluster core for magnetically amplified photothermal and photodynamic cancer therapy. ACS Appl Mater Interfaces. 2015;7:11637–47.

    Article  CAS  Google Scholar 

  • Braun GB, Pallaoro A, Wu G, Missirlis D, Zasadzinski JA, Tirrell M, Reich NO. Laser-activated gene silencing via gold nanoshell− siRNA conjugates. ACS Nano. 2009;3:2007–15.

    Article  CAS  Google Scholar 

  • Chakravarthy KV, et al. Gold nanorod delivery of an ssRNA immune activator inhibits pandemic H1N1 influenza viral replication. Proc Natl Acad Sci. 2010;107:10172–7.

    Article  CAS  Google Scholar 

  • Conde J, Doria G, Baptista P. Noble metal nanoparticles applications in cancer. J Drug Deliv. 2012;2012:751075.

    Article  Google Scholar 

  • Dykman L, Khlebtsov N. Gold nanoparticles in biomedical applications: recent advances and perspectives. Chem Soc Rev. 2012;41:2256–82.

    Article  CAS  Google Scholar 

  • Gandra N, Portz C, Nergiz SZ, Fales A, Vo-Dinh T, Singamaneni S. Inherently stealthy and highly tumor-selective gold nanoraspberries for photothermal cancer therapy. Sci Rep. 2015;5:10311.

    Article  CAS  Google Scholar 

  • Giljohann DA, Seferos DS, Prigodich AE, Patel PC, Mirkin CA. Gene regulation with polyvalent siRNA− nanoparticle conjugates. J Am Chem Soc. 2009;131:2072–3.

    Article  CAS  Google Scholar 

  • Guo S, et al. Enhanced gene delivery and siRNA silencing by gold nanoparticles coated with charge-reversal polyelectrolyte. ACS Nano. 2010;4:5505–11.

    Article  CAS  Google Scholar 

  • Hosomi C, Tooyama I, Inubushi T, Morikawa S, Yamada H. Gold nanoparticle composition, dna chip, near infrared absorbent, drug carrier for drug delivery system (dds), coloring agent, biosensor, cosmetic, composition for in vivo diagnosis and composition for therapeutic use. Google Patents. 2008.

    Google Scholar 

  • Hu F, Zhang Y, Chen G, Li C, Wang Q. Double-walled Au Nanocage/SiO2 Nanorattles: integrating SERS imaging, drug delivery and photothermal therapy. Small. 2015;11:985–93.

    Article  CAS  Google Scholar 

  • Hu Y, Wen C, Song L, Zhao N, Xu FJ. Multifunctional hetero-nanostructures of hydroxyl-rich polycation wrapped cellulose-gold hybrids for combined cancer therapy. J Control Release. 2017;255:154–63.

    Article  CAS  Google Scholar 

  • Huang X, Jain P, El-Sayed I, El-Sayed M. Special focus: nanoparticles for cancer diagnosis & therapeutics-review; gold nanoparticles: interesting optical properties and recent applications in cancer diagnostics and therapy. Nanomedicine. 2007;2:681–93.

    Article  CAS  Google Scholar 

  • Kim D, Yu MK, Lee TS, Park JJ, Jeong YY, Jon S. Amphiphilic polymer-coated hybrid nanoparticles as CT/MRI dual contrast agents. Nanotechnology. 2011;22:155101.

    Article  Google Scholar 

  • Kneipp J, Kneipp H, McLaughlin M, Brown D, Kneipp K. In vivo molecular probing of cellular compartments with gold nanoparticles and nanoaggregates. Nano Lett. 2006;6:2225–31.

    Article  CAS  Google Scholar 

  • Kojima C, Umeda Y, Ogawa M, Harada A, Magata Y, Kono K. X-ray computed tomography contrast agents prepared by seeded growth of gold nanoparticles in PEGylated dendrimer. Nanotechnology. 2010;21:245104.

    Article  Google Scholar 

  • Liu Y, Yuan H, Fales AM, Register JK, Vo-Dinh T. Multifunctional gold nanostars for molecular imaging and cancer therapy. Front Chem. 2015;3:51.

    Article  Google Scholar 

  • Luo X, Liu X, Pei Y, Ling Y, Wu P, Cai C. Leakage-free polypyrrole–Au nanostructures for combined Raman detection and photothermal cancer therapy. J Mater Chem B. 2017;5:7949–62.

    Article  CAS  Google Scholar 

  • Ma N, et al. Shape-dependent radiosensitization effect of gold nanostructures in cancer radiotherapy: comparison of gold nanoparticles, nanospikes, and nanorods. ACS Appl Mater Interfaces. 2017;9:13037–48.

    Article  CAS  Google Scholar 

  • Maier-Hauff K, et al. Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme. J Neuro-Oncol. 2011;103:317–24.

    Article  Google Scholar 

  • McGrath AJ, et al. Gold over branched palladium nanostructures for photothermal cancer therapy. ACS Nano. 2015;9:12283–91.

    Article  CAS  Google Scholar 

  • Murali K, Neelakandan MS, Thomas S. Biomedical applications of gold nanoparticles. JSM Nanotechnol Nanomed. 2018;6:1064.

    Google Scholar 

  • Ou YC, et al. Gold nanoantenna-mediated photothermal drug delivery from thermosensitive liposomes in breast cancer. ACS Omega. 2016;1:234–43.

    Article  CAS  Google Scholar 

  • Qiu P, Yang M, Qu X, Huai Y, Zhu Y, Mao C. Tuning photothermal properties of gold nanodendrites for in vivo cancer therapy within a wide near infrared range by simply controlling their degree of branching. Biomaterials. 2016;104:138–44.

    Article  CAS  Google Scholar 

  • Rand D, Ortiz V, Liu Y, Derdak Z, Wands JR, Tatíček M, Rose-Petruck C. Nanomaterials for X-ray imaging: gold nanoparticle enhancement of X-ray scatter imaging of hepatocellular carcinoma. Nano Lett. 2011;11:2678–83.

    Article  CAS  Google Scholar 

  • Rengan AK, Bukhari AB, Pradhan A, Malhotra R, Banerjee R, Srivastava R, De A. In vivo analysis of biodegradable liposome gold nanoparticles as efficient agents for photothermal therapy of cancer. Nano Lett. 2015;15:842–8.

    Article  CAS  Google Scholar 

  • Samadian H, Hosseini-Nami S, Kamrava SK, Ghaznavi H, Shakeri-Zadeh A. Folate-conjugated gold nanoparticle as a new nanoplatform for targeted cancer therapy. J Cancer Res Clin Oncol. 2016;42:2217–29.

    Article  Google Scholar 

  • Selvaraj V, Alagar M. Analytical detection and biological assay of antileukemic drug 5-fluorouracil using gold nanoparticles as probe. Int J Pharm. 2007;337:275–81.

    Article  CAS  Google Scholar 

  • Song J, et al. Ultrasmall gold nanorod vesicles with enhanced tumor accumulation and fast excretion from the body for cancer therapy. Adv Mater. 2015;27:4910–7.

    Article  CAS  Google Scholar 

  • Sun M, et al. Thermally triggered in situ assembly of gold nanoparticles for cancer multimodal imaging and photothermal therapy. ACS Appl Mater Interfaces. 2017;9:10453–60.

    Article  CAS  Google Scholar 

  • Tiwari PM, Vig K, Dennis VA, Singh SR. Functionalized gold nanoparticles and their biomedical applications. Nano. 2011;1:31–63.

    CAS  Google Scholar 

  • Turcheniuk K, et al. Plasmonic photothermal cancer therapy with gold nanorods/reduced graphene oxide core/shell nanocomposites. RSC Adv. 2016;6:1600–10.

    Article  CAS  Google Scholar 

  • Wang Y, et al. Photoacoustic tomography of a nanoshell contrast agent in the in vivo rat brain. Nano Lett. 2004;4:1689–92.

    Article  CAS  Google Scholar 

  • Zhang J, Fu Y, Mei Y, Jiang F, Lakowicz JR. Fluorescent metal nanoshell probe to detect single miRNA in lung cancer cell. Anal Chem. 2010;82:4464–71.

    Article  CAS  Google Scholar 

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Iravani, S., Soufi, G.J. (2020). Gold Nanostructures in Medicine and Biology. In: Shukla, A. (eds) Nanoparticles in Medicine. Springer, Singapore. https://doi.org/10.1007/978-981-13-8954-2_6

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  • DOI: https://doi.org/10.1007/978-981-13-8954-2_6

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-8953-5

  • Online ISBN: 978-981-13-8954-2

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