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Inflammatory and Infectious Ocular Disorders pp 19–27Cite as

Punctate Inner Choroidopathy

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Abstract

Punctate inner choroidopathy (PIC) is a relatively uncommon idiopathic inflammatory multifocal chorioretinopathy, which occurs at the level of the outer retina, retinal pigment epithelium (RPE), and inner choroid. PIC was first described in 1984 by Watzke and colleagues in a series of 10 young myopic women who presented with blurred central vision, photopsia, and paracentral scotomas (Watzke et al. 1984). PIC is considered one of the “white dot syndromes” and is reported as having a considerable overlap with acute zonal occult outer retinopathy (Gass 2003; Ahnood et al. 2017; Francis et al. 2005). The development of various imaging modalities has led to a better understanding of PIC, but whether PIC is truly a separate disease entity or simply a subset of the so-called PIC/MCP spectrum is still controversial (Jampol and Becker 2003; Spaide et al. 2013).

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References

  • Ahnood D, Madhusudhan S, Tsaloumas MD, Waheed NK, Keane PA, Denniston AK. Punctate inner choroidopathy: a review. Surv Ophthalmol. 2017;62(2):113–26.

    Article  PubMed  Google Scholar 

  • Amer R, Lois N. Punctate inner choroidopathy. Surv Ophthalmol. 2011;56(1):36–53.

    Article  PubMed  Google Scholar 

  • Arcinue CA, Ma F, Barteselli G, Sharpsten L, Gomez ML, Freeman WR. One-year outcomes of aflibercept in recurrent or persistent neovascular age-related macular degeneration. Am J Ophthalmol. 2015;159(3):426–436.e422.

    Article  CAS  PubMed  Google Scholar 

  • Brouzas D, Charakidas A, Rotsos T, Moschos MM, Loukianou H, Koutsandrea C, Ladas I, Baltatzis S. Choroidal neovascularization due to punctate inner choroidopathy: long-term follow-up and review of literature. Clin Ophthalmol (Auckland, NZ). 2010;4:871.

    Article  Google Scholar 

  • Brueggeman RM, Noffke AS, Jampol LM. Resolution of punctate inner choroidopathy lesions with oral prednisone therapy. Arch Ophthalmol. 2002;120(7):996.

    Article  PubMed  Google Scholar 

  • Chan W-M, Lai TY, Lau TT, Lee VY, Liu DT, Lam DS. Combined photodynamic therapy and intravitreal triamcinolone for choroidal neovascularization secondary to punctate inner choroidopathy or of idiopathic origin: one-year results of a prospective series. Retina. 2008;28(1):71–80.

    Article  PubMed  Google Scholar 

  • Channa R, Ibrahim M, Sepah Y, Turkcuoglu P, Lee JH, Khwaja A, Hatef E, Bittencourt M, Heo J, Do DV. Characterization of macular lesions in punctate inner choroidopathy with spectral domain optical coherence tomography. J Ophthalmic Inflamm Infect. 2012;2(3):113–20.

    Article  PubMed  PubMed Central  Google Scholar 

  • Chatterjee S, Gibson J. Photodynamic therapy: a treatment option in choroidal neovascularisation secondary to punctate inner choroidopathy. Br J Ophthalmol. 2003;87(7):925–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cirino AC, Mathura JR, Jampol LM. Resolution of activity (choroiditis and choroidal neovascularization) of chronic recurrent punctate inner choroidopathy after treatment with interferon B-1A. Retina. 2006;26(9):1091–2.

    Article  PubMed  Google Scholar 

  • Ehlers JP, Maldonado R, Sarin N, Toth CA. Treatment of non-age-related macular degeneration submacular diseases with macular translocation surgery. Retina. 2011;31(7):1337–46.

    Article  PubMed  Google Scholar 

  • Essex RW, Tufail A, Bunce C, Aylward GW. Two-year results of surgical removal of choroidal neovascular membranes related to non-age-related macular degeneration. Br J Ophthalmol. 2007;91(5):649–54.

    Article  PubMed  PubMed Central  Google Scholar 

  • Essex RW, Wong J, Fraser-Bell S, Sandbach J, Tufail A, Bird AC, Dowler J. Punctate inner choroidopathy: clinical features and outcomes. Arch Ophthalmol. 2010;128(8):982–7.

    Article  PubMed  Google Scholar 

  • Flaxel CJ, Owens SL, Mulholland B, Schwartz SD, Gregor ZJ. The use of corticosteroids for choroidal neovascularisation in young patients. Eye. 1998;12(2):266–72.

    Article  PubMed  Google Scholar 

  • Francis P, Marinescu A, Fitzke F, Bird A, Holder G. Acute zonal occult outer retinopathy: towards a set of diagnostic criteria. Br J Ophthalmol. 2005;89(1):70–3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Galor A, Jabs DA, Leder HA, Kedhar SR, Dunn JP, Peters GB, Thorne JE. Comparison of antimetabolite drugs as corticosteroid-sparing therapy for noninfectious ocular inflammation. Ophthalmology. 2008;115(10):1826–32.

    Article  PubMed  Google Scholar 

  • Gass JD. Are acute zonal occult outer retinopathy and the white spot syndromes (AZOOR complex) specific autoimmune diseases? Am J Ophthalmol. 2003;135(3):380–1.

    Article  PubMed  Google Scholar 

  • Gerstenblith AT, Thorne JE, Sobrin L, Do DV, Shah SM, Foster CS, Jabs DA, Nguyen QD. Punctate inner choroidopathy: a survey analysis of 77 persons. Ophthalmology. 2007;114(6):1201–1204. e1204.

    Article  PubMed  Google Scholar 

  • Hua R, Liu L, Chen L. Evaluation of the progression rate of atrophy lesions in punctate inner choroidopathy (PIC) based on autofluorescence analysis. Photodiagn Photodyn Ther. 2014;11(4):565–9.

    Article  Google Scholar 

  • Ip M, Gorin MB. Recurrence of a choroidal neovascular membrane in a patient with punctate inner choroidopathy treated with daily doses of thalidomide. Am J Ophthalmol. 1996;122(4):594–5.

    Article  CAS  PubMed  Google Scholar 

  • Jampol LM, Becker KG. White spot syndromes of the retina: a hypothesis based on the common genetic hypothesis of autoimmune/inflammatory disease. Am J Ophthalmol. 2003;135(3):376–9.

    Article  PubMed  Google Scholar 

  • Kedhar SR, Thorne JE, Wittenberg S, Dunn JP, Jabs DA. Multifocal choroiditis with panuveitis and punctate inner choroidopathy: comparison of clinical characteristics at presentation. Retina. 2007;27(9):1174–9.

    Article  PubMed  Google Scholar 

  • Leslie T, Lois N, Christopoulou D, Olson J, Forrester J. Photodynamic therapy for inflammatory choroidal neovascularisation unresponsive to immunosuppression. Br J Ophthalmol. 2005;89(2):147–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Leung AK, Weisbrod DJ, Schwartz C. Intravitreal ranibizumab in the treatment of choroidal neovascular membrane secondary to punctate inner choroidopathy. Can J Ophthalmol. 2010;45(3):300–1.

    Article  PubMed  Google Scholar 

  • Levison AL, Baynes KM, Lowder CY, Kaiser PK, Srivastava SK. Choroidal neovascularisation on optical coherence tomography angiography in punctate inner choroidopathy and multifocal choroiditis. Br J Ophthalmol. 2017;101(5):616–22. https://doi.org/10.1136/bjophthalmol-2016-308806.

    Article  PubMed  Google Scholar 

  • Levy J, Shneck M, Klemperer I, Lifshitz T. Punctate inner choroidopathy: resolution after oral steroid treatment and review of the literature. Can J Ophthalmol. 2005;40(5):605–8.

    Article  PubMed  Google Scholar 

  • Lim JI, Flaxel CJ, LaBree L. Photodynamic therapy for choroidal neovascularisation secondary to inflammatory chorioretinal disease. Ann Acad Med Singapore. 2006;35(3):198.

    PubMed  Google Scholar 

  • Madhusudhan S, Keane PA, Denniston AK. Adjunctive use of systematic retinal thickness map analysis to monitor disease activity in punctate inner choroidopathy. J Ophthalmic Inflamm Infect. 2016;6(1):9.

    Article  PubMed  PubMed Central  Google Scholar 

  • Mansour AM, Arevalo JF, Ziemssen F, Mehio-Sibai A, Mackensen F, Adan A, Chan W-M, Ness T, Banker AS, Dodwell D. Long-term visual outcomes of intravitreal bevacizumab in inflammatory ocular neovascularization. Am J Ophthalmol. 2009;148(2):310–316.e312.

    Article  CAS  PubMed  Google Scholar 

  • Nussenblatt RB, Coleman H, Jirawuthiworavong G, Davuluri G, Potapova N, Dahr SS, Ragheb JA, Levy-Clarke G. The treatment of multifocal choroiditis associated choroidal neovascularization with sirolimus (rapamycin). Acta Ophthalmol. 2007;85(2):230–1.

    Article  Google Scholar 

  • Olsen TW, Capone A, Sternberg P, Grossniklaus HE, Martin DF, Aaberg TM. Subfoveal choroidal neovascularization in punctate inner choroidopathy: surgical management and pathologic findings. Ophthalmology. 1996;103(12):2061–9.

    Article  CAS  PubMed  Google Scholar 

  • Rouvas A, Petrou P, Douvali M, Ntouraki A, Vergados I, Georgalas I, Markomichelakis N. Intravitreal ranibizumab for the treatment of inflammatory choroidal neovascularization. Retina. 2011;31(5):871–9.

    Article  CAS  PubMed  Google Scholar 

  • Spaide RF, Goldberg N, Freund KB. Redefining multifocal choroiditis and panuveitis and punctate inner choroidopathy through multimodal imaging. Retina. 2013;33(7):1315–24.

    Article  PubMed  Google Scholar 

  • Tiffin P, Maini R, Roxburgh S, Ellingford A. Indocyanine green angiography in a case of punctate inner choroidopathy. Br J Ophthalmol. 1996;80(1):90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Turkcuoglu P, Chang PY, Rentiya ZS, Channa R, Ibrahim M, Hatef E, Sophie R, Sadaka A, Wang J, Sepah YJ. Mycophenolate mofetil and fundus autofluorescence in the management of recurrent punctate inner choroidopathy. Ocul Immunol Inflamm. 2011;19(4):286–92.

    Article  CAS  PubMed  Google Scholar 

  • Wachtlin J, Heimann H, Behme T, Foerster MH. Long-term results after photodynamic therapy with verteporfin for choroidal neovascularizations secondary to inflammatory chorioretinal diseases. Graefes Arch Clin Exp Ophthalmol. 2003;241(11):899–906.

    Article  CAS  PubMed  Google Scholar 

  • Watzke RC, Packer AJ, Folk JC, Benson WE, Burgess D, Ober RR. Punctate inner choroidopathy. Am J Ophthalmol. 1984;98(5):572–84.

    Article  CAS  PubMed  Google Scholar 

  • Zhang H, Liu Z-L, Sun P, Gu F. Intravitreal bevacizumab as primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy: results of a 1-year prospective trial. Retina. 2012;32(6):1106–13.

    Article  CAS  PubMed  Google Scholar 

  • Zhang X, Wen F, Zuo C, Li M, Chen H, Huang S, Luo G. Clinical features of punctate inner choroidopathy in Chinese patients. Retina. 2011;31(8):1680–91.

    Article  PubMed  Google Scholar 

  • Zhang X, Zuo C, Li M, Chen H, Huang S, Wen F. Spectral-domain optical coherence tomographic findings at each stage of punctate inner choroidopathy. Ophthalmology. 2013;120(12):2678–83.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea

    Hyeong Gon Yu & Dae Joong Ma

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  1. Hyeong Gon Yu
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Correspondence to Hyeong Gon Yu .

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  1. Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea (Republic of)

    Hyeong Gon Yu

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Yu, H.G., Ma, D.J. (2020). Punctate Inner Choroidopathy. In: Yu, H. (eds) Inflammatory and Infectious Ocular Disorders. Retina Atlas. Springer, Singapore. https://doi.org/10.1007/978-981-13-8546-9_3

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  • DOI: https://doi.org/10.1007/978-981-13-8546-9_3

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