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Mitochondria in Health and in Sickness pp 71–82Cite as

Crosstalk Between Oxidative Stress and Mitochondrial Damage: Focus on Amyotrophic Lateral Sclerosis

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1158))

Abstract

Proteins oxidation by reactive species is implicated in the aetiology or progression of a panoply of disorders and diseases such as neurodegenerative disorders. It is becoming increasingly evident that redox imbalance in the brain mediates neurodegeneration. Free radicals, as reactive species of oxygen (ROS) but also reactive nitrogen species (RNS) and reactive sulfur species (RSS), are generated in vivo from several sources. Within the cell the mitochondria represent the main source of ROS and mitochondrial dysfunction is both the major contributor to oxidative stress (OS) as well its major consequence.

To date there are no doubts that a condition of OS added to other factors as mitochondrial damage in mtDNA or mitochondrial respiratory chain, may contribute to trigger or amplify mechanisms leading to neurodegenerative disorders.

In this chapter, we aim at illustrate the molecular interplay occurring between mitochondria and OS focusing on Amyotrophic Lateral Sclerosis, describing a phenotypic reprogramming mechanism of mitochondria in complex neurological disorder.

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Authors and Affiliations

  1. Institute of Biochemistry and Clinical Biochemistry, Università Cattolica del Sacro Cuore, Rome, Italy

    Viviana Greco & Andrea Urbani

  2. Fondazione Policlinico Universitario A. Gemelli – IRCCS, Rome, Italy

    Viviana Greco & Andrea Urbani

  3. Molecular Neurobiology Unit, Fondazione Santa Lucia-IRCCS, Rome, Italy

    Patrizia Longone & Alida Spalloni

  4. Proteomics and Metabonomics Unit, Fondazione Santa Lucia-IRCCS, Rome, Italy

    Luisa Pieroni

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  1. Viviana Greco
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  2. Patrizia Longone
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  3. Alida Spalloni
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  4. Luisa Pieroni
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  5. Andrea Urbani
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Correspondence to Andrea Urbani .

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Editors and Affiliations

  1. Institute of Biochemistry and Clinical Biochemistry, Università Cattolica del Sacro Cuore, Rome, Italy, Fondazione Policlinico Universitario A. Gemelli – IRCCS, Rome, Italy

    Andrea Urbani

  2. Department of Biochemistry, University of Regina, Regina, SK, Canada

    Mohan Babu

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Greco, V., Longone, P., Spalloni, A., Pieroni, L., Urbani, A. (2019). Crosstalk Between Oxidative Stress and Mitochondrial Damage: Focus on Amyotrophic Lateral Sclerosis. In: Urbani, A., Babu, M. (eds) Mitochondria in Health and in Sickness. Advances in Experimental Medicine and Biology, vol 1158. Springer, Singapore. https://doi.org/10.1007/978-981-13-8367-0_5

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