Abstract
Endothelial dysfunction is a critical factor in the development of diabetes-mediated cardiovascular complications. Free fatty acids (FFA), such as palmitate, which are elevated in diabetes and obesity, have been shown to mediate endothelial dysfunction, perhaps related to oxidative stress and inflammation. Taurine ameliorates endothelial dysfunction induced by diabetes. However, there has been no reports on the effect of Loliolus beka gray meat extracts, which contain large amounts of taurine. Here, we investigated the protective effect of a hot water extract of Loliolus beka gray meat (LBM), on palmitate-induced cell damage in human umbilical vein endothelial cells (HUVEC). The LBM extract was found to inhibit palmitate-induced cytotoxicity and DNA damage. In addition, the LBM extract reduced the level of reactive oxygen species (ROS) and nitric oxide (NO), as well as pro-inflammatory cytokines in HUVEC. These results suggest that the LBM extract protects against palmitate-induced cytotoxicity in HUVECs. Therefore, potential therapeutic and/or inhibitors of vascular disease may be derived from the LBM extract.
Ginnae Ahn and Seon-Heui Cha have been equally contributed to this chapter.
Taurine theme: Taurine and Anti-oxidation and Anti-microbial.
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Acknowledgements
This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, & Future Planning (2017R1D1A1B03033794).
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Lee, W., Han, E.J., Shin, EJ., Han, HJ., Ahn, G., Cha, SH. (2019). Protective Effect of Hot Water Extract of Loliolus Beka Gray Meat Against Palmitate-Induced HUVEC Damage. In: Hu, J., Piao, F., Schaffer, S., El Idrissi, A., Wu, JY. (eds) Taurine 11. Advances in Experimental Medicine and Biology, vol 1155. Springer, Singapore. https://doi.org/10.1007/978-981-13-8023-5_62
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DOI: https://doi.org/10.1007/978-981-13-8023-5_62
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