Abstract
In the current chapter, we provide an overview of the CAP (cyclase-associated protein) and its salient features in regulating the actin-mediated gliding motility. It is one of the highly conserved, multi-domain proteins involved in regulating the actin dynamics. Unlike the eukaryotic counterparts, CAPs in apicomplexan do not possess different isoform and lack the upstream N-terminal domain indicating a differential regulatory function. As observed in our study, CAP in apicomplexan showed lack of unique consensus motif important for actin binding except for Plasmodium vivax.
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6.1 Supplementary Electronic Material
ST_CAP-1
Sequence comparison identity matrix for CAP proteins used in the current study (XLSX 62 kb)
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Pathak, S., Gauba, R., Dantu, S.C., Kale, A. (2019). CAP (Cyclase-Associated Protein): The Silent Worker. In: Kale, A. (eds) Actin Polymerization in Apicomplexan. Springer, Singapore. https://doi.org/10.1007/978-981-13-7450-0_6
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