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Herbal Medicine in India pp 249–261Cite as

Spatio-Temporal Imaging and High-Resolution Mass Spectrometry Analysis: New Avenues in Herbal Drug Discovery and Plant Metabolomics

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Abstract

Plant secondary metabolites confer pharmacological activities to the plant. The identification of the secondary metabolites, their tissue specific content, and spatio-temporal distribution has opened new avenues for discovery of metabolite synthesis pathways in plants. Plant metabolomics is an emerging field in plant sciences that utilizes techniques for characterization, differentiation, and activity identification of secondary metabolites. With advancement in state-of-the art technology for the study of metabolites, researchers have focused their attention towards non-invasive and intact sample analysis by application of various imaging and mass spectrometry techniques. These techniques include micro-computed tomography (micro-CT), magnetic resonance imaging (MRI), and several systems utilizing mass spectrometry. These computationally assisted techniques help in exploration of complex interactions that exist between the spatial distribution and molecular composition of metabolites leading to biological variability in plants and their potency. Through various studies reported till date, the application of these techniques for identification of novel plant secondary metabolites that may serve as candidate new drugs is demonstrated.

This chapter focuses on the principles and applications of imaging and mass spectrometry techniques in plant metabolomics. These techniques serve as the future of molecular mapping in plants and they open new avenues for quality control and discovery in herbal medicine.

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  1. Center for Excellence in Post Harvest Technologies, The North Carolina Research Campus, North Carolina Agricultural and Technical State University, Kannapolis, NC, USA

    Yogini S. Jaiswal & Leonard L. Williams

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  1. Faculty of Pharmaceutical Science, Assam Down Town University, Guwahati, Assam, India

    Saikat Sen

  2. NEF College of Pharmacy, Lokhra Lalganesh Road, Lokhra, Guwahati, Assam, India

    Raja Chakraborty

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Jaiswal, Y.S., Williams, L.L. (2020). Spatio-Temporal Imaging and High-Resolution Mass Spectrometry Analysis: New Avenues in Herbal Drug Discovery and Plant Metabolomics. In: Sen, S., Chakraborty, R. (eds) Herbal Medicine in India. Springer, Singapore. https://doi.org/10.1007/978-981-13-7248-3_18

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