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Changes in the Nuclear Envelope in Laminopathies

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Book cover Biochemical and Biophysical Roles of Cell Surface Molecules

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1112))

Abstract

Double-membrane-bound nucleus is the major organelle of every metazoan cell, which controls various nuclear processes like chromatin maintenance, DNA replication, transcription and nucleoskeleton-cytoskeleton coupling. Nuclear homeostasis depends on the integrity of nuclear membrane and associated proteins. Lamins, underlying the inner nuclear membrane (INM), play a crucial role in maintaining nuclear homeostasis. In this review, we have focussed on the disruption of nuclear homeostasis due to lamin A/C mutation which produces a plethora of diseases, termed as laminopathies.

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Author information

Authors and Affiliations

  1. Biophysics & Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata, West Bengal, India

    Subarna Dutta & Kaushik Sengupta

  2. Department of Biochemistry, University of Calcutta, Kolkata, West Bengal, India

    Subarna Dutta & Maitree Bhattacharyya

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  1. Subarna Dutta
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  2. Maitree Bhattacharyya
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  3. Kaushik Sengupta
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Editors and Affiliations

  1. Centre for Protein Science, Design and Engineering, Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Mohali, Punjab, India

    Kausik Chattopadhyay

  2. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA

    Subhash C. Basu

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Dutta, S., Bhattacharyya, M., Sengupta, K. (2018). Changes in the Nuclear Envelope in Laminopathies. In: Chattopadhyay, K., Basu, S. (eds) Biochemical and Biophysical Roles of Cell Surface Molecules. Advances in Experimental Medicine and Biology, vol 1112. Springer, Singapore. https://doi.org/10.1007/978-981-13-3065-0_3

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