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Prenatal Mesenchymal Stem Cell Secretome and Its Clinical Implication

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Perinatal Stem Cells

Abstract

Mesenchymal stem cells (MSCs) possess paracrine characteristic involving in the main therapeutic effects. The soluble factors secreted by MSCs are responsible for the paracrine activity, which have attracted more and more attention. These protein factors named secretome could be related to the biological processes such as wound healing, inflammatory response, angiogenesis, cell proliferation, chemotaxis, and neurogenesis. And they have bypassed the confounding issues of MSCs themselves. The MSC secretome in MSC-conditioned media (CM) could be manufactured and used as protein drugs. The cost of manufacturing, transport, and storage of secretome is lower than that of MSCs. Prenatal MSC secretome, especially placenta MSC secretome, has higher concentration and stronger capacities than that of other origins, which is a promising alternative to stem cell therapy for various diseases treatment.

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Author information

Authors and Affiliations

  1. Tianjin Bion Bio-tech Co., Ltd., Tianjin, China

    Lu Liang

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  1. Lu Liang
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Editor information

Editors and Affiliations

  1. Beijing Engineering Laboratory of Perinatal Stem Cells, Jiangxi Engineering Research Center for Stem Cell, Health & Biotech Co., Beijing, China

    Zhong Chao Han

  2. Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

    Tsuneo A. Takahashi

  3. State Key Lab of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin, China

    Zhibo Han

  4. School of Medicine, Nankai University, Tianjin, China

    Zongjin Li

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Liang, L. (2019). Prenatal Mesenchymal Stem Cell Secretome and Its Clinical Implication. In: Han, Z., Takahashi, T., Han, Z., Li, Z. (eds) Perinatal Stem Cells. Springer, Singapore. https://doi.org/10.1007/978-981-13-2703-2_13

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  • DOI: https://doi.org/10.1007/978-981-13-2703-2_13

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-2702-5

  • Online ISBN: 978-981-13-2703-2

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