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Drug-Induced Nephrotoxicity

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Critical Care Pediatric Nephrology and Dialysis: A Practical Handbook

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Abstract

A 6-year-old female with a history of spina bifida is admitted for presumed acute pyelonephritis with fevers, vomiting, and abdominal pain. Her urine culture and sensitivity results are pending. She has a past medical history significant for a ventriculoperitoneal (VP) shunt, gastrostomy tube, and neurogenic bladder. She has been admitted several times in the past for pyelonephritis with bacteremia. Her baseline renal function equates to an estimated glomerular filtration rate (eGFR) of approximately 60 mL/min/1.73 m2. You are consulted by the hospitalist to provide input regarding the choice of antibiotic and dosage to be prescribed.

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Suggested Readings

  1. Pierson-Marchandise M, Gras V, Moragny J, Micallef J, Gaboriau L, Picard S, Choukroun G, Masmoudi K, Liabeuf S, French National Network of Pharmacovigilance Centres. The drugs that mostly frequently induce acute kidney injury: a case - noncase study of a pharmacovigilance database. Br J Clin Pharmacol. 2017;83(6):1341–9. https://doi.org/10.1111/bcp.13216.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Aronoff G, Berns J, Brier M, et al. Drug prescribing in renal failure. 4th ed. Philadelphia: American College of Physicians; 1999. p. 1–12.

    Google Scholar 

  3. Abouelkheir M, Alsubaie S. Acute kidney injury induced by concomitant use of vancomycin and piperacillin-tazobactam in pediatrics. Pediatr Int. 2018;60(2):136–41.

    Article  CAS  Google Scholar 

  4. Wu H, Huang J. Drug-induced nephrotoxicity: pathogenic mechanisms, biomarkers and prevention strategies. Curr Drug Metab. 2018;19(7):559–67.

    Article  CAS  Google Scholar 

  5. Nolin TD, Himmelfarb J. Mechanisms of drug-induced nephrotoxicity. In: Uetrecht J, editor. Adverse drug reactions. Handbook of experimental pharmacology, vol. 196. Berlin: Springer; 2010. p. 111–30.

    Chapter  Google Scholar 

  6. Schetz M, Dasta J, Goldstein S, Golper T. Drug-induced acute kidney injury. Curr Opin Crit Care. 2005;11(6):555–65.

    Article  Google Scholar 

  7. Pannu N, Nadim MK. An overview of drug-induced acute kidney injury. Crit Care Med. 2008;36(4 Suppl):S216–23. https://doi.org/10.1097/CCM.0b013e318168e375.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Abbvie, University of Illinois College of Medicine, Chicago, IL, USA

    Deepa H. Chand

  2. Research and Development, Abbvie, Inc., North Chicago, IL, USA

    Meenal Patwardhan

Authors
  1. Deepa H. Chand
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  2. Meenal Patwardhan
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Editor information

Editors and Affiliations

  1. Kidney & Urology Institute, Medanta, The Medicity Kidney & Urology Institute, Gurugram, Haryana, India

    Sidharth Kumar Sethi

  2. Department of Nephrology, Cleveland Clinic Akron General Medical center and Akron Children’s Hospital, Akron, OH, USA

    Rupesh Raina

  3. Red Cross War Memorial Children’s Hospital, University of Cape Town, Cape Town, South Africa

    Mignon McCulloch

  4. Pediatric Nephrology, Children’s Hospital of Richmond at the Virginia Commonwealth University, Richmond, VA, USA

    Timothy E. Bunchman

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© 2019 Springer Nature Singapore Pte Ltd.

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Chand, D.H., Patwardhan, M. (2019). Drug-Induced Nephrotoxicity. In: Sethi, S., Raina, R., McCulloch, M., Bunchman, T. (eds) Critical Care Pediatric Nephrology and Dialysis: A Practical Handbook. Springer, Singapore. https://doi.org/10.1007/978-981-13-2276-1_18

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  • DOI: https://doi.org/10.1007/978-981-13-2276-1_18

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-2275-4

  • Online ISBN: 978-981-13-2276-1

  • eBook Packages: MedicineMedicine (R0)

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