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Preventing Muscle Atrophy Following Strokes: A Reappraisal

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Book cover Muscle Atrophy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1088))

Abstract

Muscle atrophy leading to muscle weakness accounts for major cause of disabilities among stroke survivors. It amounts to compromised gait and prevails to viscous cycle of diminished physical capacities and compromised participation in rehabilitative tasks. There is predisposition to recurrent strokes due to added risk of developing metabolic syndrome. Therefore, beyond the shadow of doubt, there is ripple effect of rehabilitation and thereby muscle protection in these subsets of patients. Herein, we highlight upon the newer insights with regard to preventing muscle atrophy following strokes.

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References

  1. Fried L, Ettinger W, Lind B, Newman A, Gardin J (1994) Physical disability in older adults: a physiological approach. J Clin Epidemiol 47(7):747–760

    Article  CAS  Google Scholar 

  2. Gresham G, Fitzpatrick T, Wolf P, McNamara P, Kannel W, Dawber T (1975) Residual disability in survivors of stroke — the Framingham study. N Engl J Med 293(19):954–956

    Article  CAS  Google Scholar 

  3. Roger V, Go A, Lloyd-Jones D, Benjamin E, Berry J, Borden W, Bravata D, Dai S, Ford E, Fox C, Fullerton H, Gillespie C, Hailpern S, Heit J, Howard V, Kissela B, Kittner S, Lackland D, Lichtman J, Lisabeth L, Makuc D, Marcus G, Marelli A, Matchar D, Moy C, Mozaffarian D, Mussolino M, Nichol G, Paynter N, Soliman E, Sorlie P, Sotoodehnia N, Turan T, Virani S, Wong N, Woo D, Turner M (2011) Heart disease and stroke statistics--2012 update: a report from the American Heart Association. Circulation 125(1):e2–e220

    PubMed  PubMed Central  Google Scholar 

  4. Wade D, Hewer R (1987) Functional abilities after stroke: measurement, natural history and prognosis. J Neurol Neurosurg Psychiatry 50(2):177–182

    Article  CAS  Google Scholar 

  5. Duncan P, Richards L, Wallace D, Stoker YJ, Pohl P, Luchies C, Ogle A, Studenski S (1998) A randomized controlled pilot study of a home-based exercise program for individuals with mild and moderate stroke. Stroke 29(10):2055–2060

    Article  CAS  Google Scholar 

  6. Kumar S, Roy G, Kar S (2012) Disability and rehabilitation services in India: Issues and challenges. J Fam Med Prim Care 1(1):69. https://doi.org/10.4103/2249-4863.94458

    Article  CAS  Google Scholar 

  7. Scherbakov N, von HS, Anker S, Dirnagl U, Doehner W (2013) Stroke induced sarcopenia: muscle wasting and disability after stroke. Int J Cardiol 170(2):89–94. https://doi.org/10.1016/j.ijcard.2013.10.031

    Article  PubMed  Google Scholar 

  8. Hunter R, Stevenson E, Koncarevic A, Mitchell FH, Essig D, Kandarian S (2002) Activation of an alternative NF-κB pathway in skeletal muscle during disuse atrophy. FASEB J 16(6):529–538

    Article  CAS  Google Scholar 

  9. Hafer MC, Yu S, Ryan A, Ivey F, Macko R (2005) Elevated tumor necrosis factor- in skeletal muscle after stroke. Stroke 36(9):2021–2023

    Article  Google Scholar 

  10. De DP, Hafer MC, Ivey F, Ryan A, Macko R (2004) Muscle molecular phenotype after stroke is associated with gait speed. Muscle Nerve 30(2):209–215

    Article  Google Scholar 

  11. Landin S, Hagenfeldt L, Saltin B, Wahren J (1977) Muscle metabolism during exercise in hemiparetic patients. Clin Sci 53(3):257–269

    Article  CAS  Google Scholar 

  12. Ivey F, Gardner A, Dobrovolny C, Macko R (2004) Unilateral impairment of leg blood flow in chronic stroke patients. Cerebrovasc Dis 18(4):283–289

    Article  Google Scholar 

  13. Hafer MC (2008) Skeletal muscle changes after hemiparetic stroke and potential beneficial effects of exercise intervention strategies. J Rehabil Res Dev 45(2):261–272

    Article  Google Scholar 

  14. Ivey F, Ryan A, Hafer MC, Garrity B, Sorkin J, Goldberg A, Macko R (2006) High prevalence of abnormal glucose metabolism and poor sensitivity of fasting plasma glucose in the chronic phase of stroke. Cerebrovasc Dis 22(5-6):368–371

    Article  CAS  Google Scholar 

  15. Ivey F, Macko R, Ryan A, Hafer MC (2005) Cardiovascular health and fitness after stroke. Top Stroke Rehabil 12(1):1–16

    Article  CAS  Google Scholar 

  16. Mol V, Baker C (1991) Activity intolerance in the geriatric stroke patient. Rehabil Nurs 16(6):337–343

    Article  CAS  Google Scholar 

  17. Ivey F, Hafer MC, Macko R (2006) Exercise rehabilitation after stroke. NeuroRx 3(4):439–450

    Article  Google Scholar 

  18. Desgeorges M, Devillard X, Toutain J, Divoux D, Castells J, Bernaudin M, Touzani O, Freyssenet D (2015) Molecular mechanisms of skeletal muscle atrophy in a mouse model of cerebral ischemia. Stroke 46(6):1673–1680. https://doi.org/10.1161/STROKEAHA.114.008574

    Article  CAS  PubMed  Google Scholar 

  19. Coelho JH, Gambassi B, Diniz T, Fernandes I, Caperuto É, Uchida M, Lira F, Rodrigues B (2016) Inflammatory mechanisms associated with skeletal muscle sequelae after stroke: role of physical exercise. Mediat Inflamm:1–19. https://doi.org/10.1155/2016/3957958

    Article  Google Scholar 

  20. Kortebein P, Ferrando A, Lombeida J, Wolfe R, Evans W (2007) Effect of 10 Days of bed rest on skeletal muscle in healthy older adults. JAMA 297(16):1769

    Article  Google Scholar 

  21. Dobkin B (2007) Fatigue versus activity-dependent fatigability in patients with central or peripheral motor impairments. Neurorehabil Neural Repair 22(2):105–110

    Article  Google Scholar 

  22. Barritt A, Smithard D (2011) Targeting fatigue in stroke patients. ISRN Neurol 2011:1–6

    Article  Google Scholar 

  23. Berenpas F, Martens A, Weerdesteyn V, Geurts A, van AN (2017) Bilateral changes in muscle architecture of physically active people with chronic stroke: a quantitative muscle ultrasound study. Clin Neurophysiol 128(1):115–122. https://doi.org/10.1016/j.clinph.2016.10.096

    Article  PubMed  Google Scholar 

  24. Mattlage A, Rippee M, Sandt J, Billinger S (2016) Decrease in insulin-like growth factor-1 and insulin-like growth factor-1 ratio in the first week of stroke is related to positive outcomes. J Stroke Cerebrovasc Dis 25(7):1800–1806. https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.03.054

    Article  PubMed  PubMed Central  Google Scholar 

  25. Scherbakov N, Knops M, Ebner N, Valentova M, Sandek A, Grittner U, Dahinden P, Hettwer S, Schefold J, von HS, Anker S, Joebges M, Doehner W (2015) Evaluation of C-terminal Agrin Fragment as a marker of muscle wasting in patients after acute stroke during early rehabilitation. J Cachexia Sarcopenia Muscle 7(1):60–67. https://doi.org/10.1002/jcsm.12068

    Article  PubMed  PubMed Central  Google Scholar 

  26. Albers G, Marks M, Kemp S, Christensen S, Tsai J, Ortega GS, McTaggart R, Torbey M, Kim TM, Leslie MT, Sarraj A, Kasner S, Ansari S, Yeatts S, Hamilton S, Mlynash M, Heit J, Zaharchuk G, Kim S, Carrozzella J, Palesch Y, Demchuk A, Bammer R, Lavori P, Broderick J, Lansberg M (2018) Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N Engl J Med 378(8):708–718. https://doi.org/10.1056/NEJMoa1713973

    Article  PubMed  Google Scholar 

  27. Chung C (2000) Striatocapsular haemorrhage. Brain 123(9):1850–1862

    Article  Google Scholar 

  28. Hsieh C, Chen C, Chiang Y, Chang C, Chang C (2008) Role of diffusion tensor imaging in a patient with spontaneous intracerebral hematoma treated by stereotactic evacuation. Surg Neurol 70(1):75–78

    Article  Google Scholar 

  29. Greiwe J, Cheng B, Rubin D, Yarasheski K, Semenkovich C (2001) Resistance exercise decreases skeletal muscle tumor necrosis factor α in frail elderly humans. FASEB J 15(2):475–482

    Article  CAS  Google Scholar 

  30. Duncan P, Studenski S, Richards L, Gollub S, Lai S, Reker D, Perera S, Yates J, Koch V, Rigler S, Johnson D (2003) Randomized clinical trial of therapeutic exercise in subacute stroke. Stroke 34(9):2173–2180

    Article  Google Scholar 

  31. Naritomi H, Moriwaki H, Metoki N, Nishimura H, Higashi Y, Yamamoto Y, Yuasa H, Oe H, Tanaka K, Saito K, Terayama Y, Oda T, Tanahashi N, Kondo H (2010) Effects of edaravone on muscle atrophy and locomotor function in patients with ischemic stroke. Drugs R&D 10(3):155–163

    Article  Google Scholar 

  32. Pollock A, Baer G, Campbell P, Choo P, Forster A, Morris J, Pomeroy V, Langhorne P (2014) Physical rehabilitation approaches for the recovery of function and mobility following stroke. Cochrane Database Syst Rev 4:CD001920. https://doi.org/10.1002/14651858.CD001920.pub3

    Article  Google Scholar 

  33. Gray V, Rice C, Garland S (2012) Factors that influence muscle weakness following stroke and their clinical implications: a critical review. Physiother Can 64(4):415–426. https://doi.org/10.3138/ptc.2011-03

    Article  PubMed  PubMed Central  Google Scholar 

  34. Biasin L, Sage M, Brunton K, Fraser J, Howe J, Bayley M, Brooks D, McIlroy W, Mansfield A, Inness E (2014) Integrating aerobic training within subacute stroke rehabilitation: a feasibility study. Phys Ther 94(12):1796–1806. https://doi.org/10.2522/ptj.20130404

    Article  PubMed  PubMed Central  Google Scholar 

  35. Macko R, Katzel L, Yataco A, Tretter L, DeSouza C, Dengel D, Smith G, Silver K (1997) Low-velocity graded treadmill stress testing in hemiparetic stroke patients. Stroke 28(5):988–992

    Article  CAS  Google Scholar 

  36. Wist S, Clivaz J, Sattelmayer M (2016) Muscle strengthening for hemiparesis after stroke: a meta-analysis. Ann Phys Rehabil Med 59(2):114–124. https://doi.org/10.1016/j.rehab.2016.02.001

    Article  PubMed  Google Scholar 

  37. Lomaglio M, Eng J (2005) Muscle strength and weight-bearing symmetry relate to sit-to-stand performance in individuals with stroke. Gait Posture 22(2):126–131. https://doi.org/10.1016/j.gaitpost.2004.08.002

    Article  PubMed  PubMed Central  Google Scholar 

  38. Jung J, Ko S, Lee S (2014) Immediate effects of single-leg stance exercise on dynamic balance, weight bearing and gait cycle in stroke patients. Phys Ther Rehabil Sci 3(1):49–54. https://doi.org/10.14474/ptrs.2014.3.1.49

    Article  Google Scholar 

  39. Harris LM, Forrester L, Macko R, Silver K, Smith G (2001) Hemiparetic gait parameters in overground versus treadmill walking. Neurorehabil Neural Repair 15(2):105–112. https://doi.org/10.1177/154596830101500204

    Article  Google Scholar 

  40. Song G, Heo J (2015) The effect of modified bridge exercise on balance ability of stroke patients. J Phys Ther Sci 27(12):3807–3810. https://doi.org/10.1589/jpts.27.3807

    Article  PubMed  PubMed Central  Google Scholar 

  41. Macko R, Smith G, Dobrovolny C, Sorkin J, Goldberg A, Silver K (2001) Treadmill training improves fitness reserve in chronic stroke patients. Arch Phys Med Rehabil 82(7):879–884. https://doi.org/10.1053/apmr.2001.23853

    Article  CAS  PubMed  Google Scholar 

  42. Macko R, DeSouza C, Tretter L, Silver K, Smith G, Anderson P, Tomoyasu N, Gorman P, Dengel D (1997) Treadmill aerobic exercise training reduces the energy expenditure and cardiovascular demands of hemiparetic gait in chronic stroke patients: a preliminary report. Stroke 28(2):326–330

    Article  CAS  Google Scholar 

  43. Mang C, Campbell K, Ross C, Boyd L (2013) Promoting neuroplasticity for motor rehabilitation after stroke: considering the effects of aerobic exercise and genetic variation on brain-derived neurotrophic factor. Phys Ther 93(12):1707–1716. https://doi.org/10.2522/ptj.20130053

    Article  PubMed  PubMed Central  Google Scholar 

  44. Potempa K, Braun L, Tinknell T, Popovich J (1996) Benefits of aerobic exercise after stroke. Sports Med 21(5):337–346

    Article  CAS  Google Scholar 

  45. Kita K, Otaka Y, Takeda K, Sakata S, Ushiba J, Kondo K, Liu M, Osu R (2013) A pilot study of sensory feedback by transcutaneous electrical nerve stimulation to improve manipulation deficit caused by severe sensory loss after stroke. J NeuroEng Rehabi 10(1):55. https://doi.org/10.1186/1743-0003-10-55

    Article  Google Scholar 

  46. Francisco G, Boake C (2003) Improvement in walking speed in poststroke spastic hemiplegia after intrathecal baclofen therapy: a preliminary study. Arch Phys Med Rehabil 84(8):1194–1199

    Article  Google Scholar 

  47. Munakomi S, Bhattarai B, Mohan KB (2017) Role of bromocriptine in multi-spectral manifestations of traumatic brain injury. Chin J Traumatol 20(2):84–86. https://doi.org/10.1016/j.cjtee.2016.04.009

    Article  PubMed  PubMed Central  Google Scholar 

  48. Thieme H, Mehrholz J, Pohl M, Behrens J, Dohle C (2013) Mirror therapy for improving motor function after stroke. J Neurol Sci 333:e573. https://doi.org/10.1016/j.jns.2013.07.2004

    Article  Google Scholar 

  49. Gurbuz N, Afsar S, Ayaş S, Cosar S (2016) Effect of mirror therapy on upper extremity motor function in stroke patients: a randomized controlled trial. J Phys Ther Sci 28(9):2501–2506. https://doi.org/10.1589/jpts.28.2501

    Article  PubMed  PubMed Central  Google Scholar 

  50. Laver K, George S, Thomas S, Deutsch J, Crotty M (2015) Virtual reality for stroke rehabilitation. Cochrane Database Syst Rev 2:CD008349. https://doi.org/10.1002/14651858.CD008349.pub3

    Article  Google Scholar 

  51. Kahn L, Lum P, Rymer W, Reinkensmeyer D (2006) Robot-assisted movement training for the stroke-impaired arm: Does it matter what the robot does? J Rehabil Res Dev 43(5):619

    Article  Google Scholar 

  52. Scherbakov N, Ebner N, Sandek A, Meisel A, Haeusler K, von Haehling S, Anker S, Dirnagl U, Joebges M, Doehner W (2016) Influence of essential amino acids on muscle mass and muscle strength in patients with cerebral stroke during early rehabilitation: protocol and rationale of a randomized clinical trial (AMINO-Stroke Study). BMC Neurol 16(1). https://doi.org/10.1186/s12883-016-0531-5

  53. Steinberg G, Kondziolka D, Wechsler L, Lunsford L, Coburn M, Billigen J, Kim A, Johnson J, Bates D, King B, Case C, McGrogan M, Yankee E, Schwartz N (2016) Clinical outcomes of transplanted modified bone marrow–derived mesenchymal stem cells in stroke. Stroke 47(7):1817–1824. https://doi.org/10.1161/STROKEAHA.116.012995

    Article  PubMed  PubMed Central  Google Scholar 

  54. Desgeorges M, Devillard X, Toutain J, Castells J, Divoux D, Arnould D, Haqq C, Bernaudin M, Durieux A, Touzani O, Freyssenet D (2017) Pharmacological inhibition of myostatin improves skeletal muscle mass and function in a mouse model of stroke. Sci Rep 7(1):14000

    Article  Google Scholar 

  55. Nowak D, Grefkes C, Ameli M, Fink G (2009) Interhemispheric competition after stroke: brain stimulation to enhance recovery of function of the affected hand. Neurorehabil Neural Repair 23(7):641–656. https://doi.org/10.1177/1545968309336661

    Article  PubMed  Google Scholar 

  56. Barros GS, Borba CSR, Borba SP, Cabral M, Monte SK (2014) Efficacy of coupling repetitive transcranial magnetic stimulation and physical therapy to reduce upper-limb spasticity in patients with stroke: a randomized controlled trial. Arch Phys Med Rehabil 95(2):222–229. https://doi.org/10.1016/j.apmr.2013.10.023

    Article  Google Scholar 

  57. Velozo C, Woodbury M (2011) JSP: translating measurement findings into rehabilitation practice: an example using Fugl-Meyer assessment-upper extremity with patients following stroke. J Rehabil Res Dev 48(10):3

    Article  Google Scholar 

  58. www.who.int/disabilities/world_report/2011/chapter4.pdf

  59. Chumbler N, Rose D, Griffiths P, Quigley P, McGee HN, Carlson K, Vandenberg P, Morey M, Sanford J, Hoenig H (2010) Study protocol: home-based telehealth stroke care: a randomized trial for veterans. Trials 11(1). https://doi.org/10.1186/1745-6215-11-74

  60. Johnson M, Rai R, Barathi S, Mendonca R, Bustamante VK (2017) Affordable stroke therapy in high-, low- and middle-income countries: from theradrive to rehab CARES, a compact robot gym. J Rehabil Assistive Technol Eng 4:205566831770873. https://doi.org/10.1177/2055668317708732

    Article  Google Scholar 

  61. Pang M, Eng J, Dawson A, McKay H, Harris J (2005) A community-based fitness and mobility exercise program for older adults with chronic stroke: a randomized, controlled trial. J Am Geriatr Soc 53(10):1667–1674

    Article  Google Scholar 

  62. Eng J, Chu K, Maria KC, Dawson A, Carswell A, Hepburn K (2003) A community-based group exercise program for persons with chronic stroke. Med Sci Sports Exerc 35(8):1271–1278. https://doi.org/10.1111/j.1532-5415.2005.53521.x

    Article  PubMed  PubMed Central  Google Scholar 

  63. Hankey G, Jamrozik K, Broadhurst R, Forbes S, Anderson C (2002) Long-term disability after first-ever stroke and related prognostic factors in the Perth community stroke study, 1989–1990. Stroke 33(4):1034–1040

    Article  Google Scholar 

  64. Chu KS, Eng JJ, Dawson AS, Harris JE, Ozkaplan A, Gylfadóttir S (2004) A randomized controlled trial of water-based exercise for cardiovascular fitness in individuals with chronic stroke. Arch Phys Med Rehabil 85(6):870–874

    Article  Google Scholar 

  65. Brinkmann J, Hoskins T (1979) Physical conditioning and altered self-concept in rehabilitated hemiplegic patients. Phys Ther 59(7):859–865

    Article  CAS  Google Scholar 

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Munakomi, S. (2018). Preventing Muscle Atrophy Following Strokes: A Reappraisal. In: Xiao, J. (eds) Muscle Atrophy. Advances in Experimental Medicine and Biology, vol 1088. Springer, Singapore. https://doi.org/10.1007/978-981-13-1435-3_28

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