The Genetic Paradigm of WT1 Gene in Heart Development and Cardiac Repair

Liu, Xueqing; Chen, Min; Deng, Xiaoming; Ding, Zhaoping

doi:10.1007/978-981-13-1429-2_6

Xueqing Liu⁴,
Min Chen⁵,
Xiaoming Deng⁶ &
…
Zhaoping Ding^6,7

Part of the book series: Translational Bioinformatics ((TRBIO,volume 16))

400 Accesses

Abstract

Wilms’ tumor gene (WT1) is known as a tumor repressor gene causatively involved in not only eponymous nephroblastoma as initially described but also in many other incidences of pediatric malignancies. In recent decades, WT1 is also recognized as a master switch that tips the balance of epithelial-to-mesenchymal transition (EMT) that imparts the formation of multiple mesodermal organs in the embryonic development and tissue integrity in adulthood. In this chapter, we review the genetic paradigm and the developmental significance of WT1 and, particularly, recent findings demonstrating how the WT1-expressing cells transcriptionally contribute to the formation of the second heart field and constitute partially the cellular composition of the compact heart, including cardiomyocytes, cardiac fibroblasts, and coronary complex. Drawing on these findings, we highlight the epicardial redeployment of WT1 expression in response to ischemic injury and the reparative role of the fetal reprogramming that confers the formation of multipotent cardiac progenitors that may potentially be utilized for cell-based therapy for ischemic heart disease and heart failure.

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Acknowledgment

This study was funded by NSFC 81570244.

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Authors and Affiliations

Department of Cardiology, Danyang People’s Hospital, Danyang, Jiangsu, China
Xueqing Liu
Department of Physiology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China
Min Chen
Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai, China
Xiaoming Deng & Zhaoping Ding
Institute of Molecular Cardiology, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany
Zhaoping Ding

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Xueqing Liu
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Min Chen
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Xiaoming Deng
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Zhaoping Ding
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Correspondence to Zhaoping Ding .

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Zhongshan Hospital, Fudan University, Shanghai, China
Hong Jiang
Zhongshan Hospital, Fudan University, Shanghai, China
Ming Liu

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Liu, X., Chen, M., Deng, X., Ding, Z. (2018). The Genetic Paradigm of WT1 Gene in Heart Development and Cardiac Repair. In: Jiang, H., Liu, M. (eds) Heart Genomics. Translational Bioinformatics, vol 16. Springer, Singapore. https://doi.org/10.1007/978-981-13-1429-2_6

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DOI: https://doi.org/10.1007/978-981-13-1429-2_6
Published: 12 October 2018
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-1428-5
Online ISBN: 978-981-13-1429-2
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