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Flavonoids and Cancer Stem Cells Maintenance and Growth

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Functional Food and Human Health

Abstract

Normal stem cells are known to possess three important characteristics of self-renewal, restriction on stem cell numbers and ability to divide and differentiate. Compared to normal stem cells, the cancer stem cells (CSCs) have no control on the stem cell numbers. CSCs constitute a miniscule number of cells in the tumour and are responsible for tumour growth, recurrence and progression. CSCs play a vital role in drug resistance, EMT and metastasis, which are responsible for approximately 90% of cancer-related deaths. Thus, targeting CSCs has now gained significant importance in the control and treatment of various cancers. Traditional cancer therapy regimens have not been successful against cancer drug resistance and metastasis. In the recent past, numerous dietary compounds derived from natural sources have been found effective in chemoprevention and treatment of various cancers. Flavonoids are one of such naturally occurring polyphenolic compounds that are found abundantly in fruits, vegetables, tea, seeds, grains, nuts and some traditional medicinal herbs. Various flavonoids have also been shown to have an inhibitory effect on the self-renewal potential and survival of cancer stem cells of different origins. The aim of this chapter is to focus on cancer stem cells and their role in tumour progression and drug resistance and how chemoprevention using flavonoids can become an effective tool to control cancer growth.

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Acknowledgements

The fellowships from UGC to KK, CSIR to AS and DST INSPIRE to HA and Ramanujan Fellowship Award from DST to UCSY are thankfully acknowledged.

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Authors and Affiliations

  1. School of Life Sciences, Central University of Gujarat, Gandhinagar, Gujarat, India

    Kushal Kandhari, Hina Agraval, Arpana Sharma & Umesh C. S. Yadav

  2. Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India

    Rana P. Singh

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  1. Kushal Kandhari
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  2. Hina Agraval
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  4. Umesh C. S. Yadav
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Correspondence to Rana P. Singh .

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  1. Department of Biotechnology, Jaypee Institute of Information Technology, Noida, Uttar Pradesh, India

    Vibha Rani

  2. School of Life Sciences, Central University of Gujarat, Gandhinagar, Gujarat, India

    Umesh C. S. Yadav

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Kandhari, K., Agraval, H., Sharma, A., Yadav, U.C.S., Singh, R.P. (2018). Flavonoids and Cancer Stem Cells Maintenance and Growth. In: Rani, V., Yadav, U. (eds) Functional Food and Human Health. Springer, Singapore. https://doi.org/10.1007/978-981-13-1123-9_26

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