Abstract
Gastric cancer remains one of the most common cancers in the world, being the third most common cause of cancer death and the fifth most common malignancy. Incidence rate of gastric cancer is highest in East Asia including Japan, Korea, and China. More than half of new gastric cancer cases in the world have been diagnosed in East Asia. Gastric cancer is not a disease of the past in Japan like other developed Western countries. Although mortality and morbidity rates of gastric cancer have been dramatically declining in Japan, the absolute number of gastric cancer deaths has remained constant for a few decades. The number of deaths has begun to decline in recent years. Interestingly, gastric cancers detected in Japan have characteristic features. Mortality rates in Japan are considerably lower than incidence rates due to the impact of diagnosis and treatment of early-stage gastric cancers.
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References
Center for cancer control and information service, National cancer center, Japan. https://ganjoho.jp/reg_stat/statistics/stat/summary.html.
Tajima K. An outline of epidemiological features of gastric cancer in Japan. Nihon Rinsho. 2014;72(Suppl 1):39–46. Japanese.
Asaka M, Kimura T, Kudo M, et al. Relationship of Helicobacter pylori to serum pepsinogens in an asymptomatic Japanese population. Gastroenterology. 1992;102(3):760–6.
National institute of population and social security research, Japan. http://www.ipss.go.jp/index-e.asp.
Katanoda K, Kamo K, Saika K, et al. Short-term projection of cancer incidence in Japan using an age-period interaction model with spline smoothing. Jpn J Clin Oncol. 2014;44:36–41.
Tsuda M, Asaka M, Kato M, et al. Effect on Helicobacter pylori eradication therapy against gastric cancer in Japan. Helicobacter. 2017;22(5).
Joossens JV, Hill MJ, Elliott P, et al. Dietary salt, nitrate and stomach cancer mortality in 24 countries. European Cancer Prevention (ECP) and the INTERSALT Cooperative Research Group. Int J Epidemiol. 1996;25(3):494–504.
Nobuta A, Asaka M, Sugiyama T, et al. Helicobacter pylori infection in two areas in Japan with different risks for gastric cancer. Aliment Pharmacol Ther. 2004;20(Suppl 1):1–6.
IARC H. pylori Working Group. H. pylori eradication as a strategy for preventing gastric cancer. International Agency for Research on Cancer (IARC Working Group Reports, No 8). 2014;8.
Fukutomi H, Sakita T. Analysis of early gastric cancer cases collected from major hospitals and institutes in Japan. Jpn J Clin Oncol. 1984;14(2):169–79.
Matsui T, Nagahama T, Chounan A, et al. Natural history of early gastric cancer—multicenter follow-up study. Stomach Intestine. 2008;43(12):1798–809. Japanese.
Tsukuma H, Oshima A, Narahara H, et al. Natural history of early gastric cancer: a non-concurrent, long term, follow up study. Gut. 2000;47(5):618–21.
Stolte M. The new Vienna classification of epithelial neoplasia of the gastrointestinal tract: advantages and disadvantages. Virchows Arch. 2003;442:99–106.
Bosman FT, Carneiro F, Hruban RH, et al. WHO classification of tumours of the digestive system. 4th ed. 2010.
Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma: 3rd English edition. Gastric Cancer. 2011;14:101–12.
Schlemper RJ, Riddell RH, Kato Y, et al. The Vienna classification of gastrointestinal epithelial neoplasia. Gut. 2000;47(2):251–5.
Dixon MF. Gastrointestinal epithelial neoplasia: Vienna revisited. Gut. 2002;51(1):130–1.
Honda M, Wong SL, Healy MA, et al. Long-term Trends in Primary Sites of Gastric Adenocarcinoma in Japan and the United States. J Cancer. 2017;8(11):1935–42.
Inoue M, Tsugane S. Epidemiology of gastric cancer in Japan. Postgrad Med J. 2005;81(957):419–24.
Asaka M, Kato M, Kudo M, et al. Atrophic changes of gastric mucosa are caused by Helicobacter pylori infection rather than aging: studies in asymptomatic Japanese adults. Helicobacter. 1996;1(1):52–6.
Egi Y, Ito M, Tanaka S, et al. Role of Helicobacter pylori infection and chronic inflammation in gastric cancer in the cardia. Jpn J Clin Oncol. 2007;37(5):365–9.
Kato M, Asaka M. Recent knowledge of the relationship between Helicobacter pylori and gastric cancer and recent progress of gastroendoscopic diagnosis and treatment for gastric cancer. Jpn J Clin Oncol. 2010;40(9):828–37.
Ueda J, Gosho M, Inui Y, et al. Prevalence of Helicobacter pylori infection by birth year and geographic area in Japan. Helicobacter. 2014;19(2):105–10.
Kikuchi S, Nakajima T, Kobayashi O, et al. Effect of age on the relationship between gastric cancer and Helicobacter pylori. Tokyo Research Group of Prevention for Gastric Cancer. Jpn J Cancer Res. 2000;91(8):774–9.
Fujimoto Y, Furusyo N, Toyoda K, et al. Intrafamilial transmission of Helicobacter pylori among the population of endemic areas in Japan. Helicobacter. 2007;12(2):170–6.
Kamada T, Tanaka A, Yamanaka Y, et al. Nodular gastritis with Helicobacter pylori infection is strongly associated with diffuse-type gastric cancer in young patients. Dig Endosc. 2007;19:180–4.
Tsugane S, Sasazuki S. Diet and the risk of gastric cancer: review of epidemiological evidence. Gastric Cancer. 2007;10(2):75–83. Epub 2007 Jun 25.
Tsugane S. Salt, salted food intake, and risk of gastric cancer: epidemiologic evidence. Cancer Sci. 2005;96(1):1–6.
Kato S, Tsukamoto T, Mizoshita T, Tanaka H, Kumagai T, Ota H, Katsuyama T, Asaka M, Tatematsu M. High salt diets dose-dependently promote gastric chemical carcinogenesis in Helicobacter pylori-infected Mongolian gerbils associated with a shift in mucin production from glandular to surface mucous cells. Int J Cancer. 2006;119(7):1558–66.
Nishino Y, Inoue M, Tsuji I, Wakai K, Nagata C, Mizoue T, Tanaka K, Tsugane S. Tobacco smoking and gastric cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the japanese population. Jpn J Clin Oncol. 2006;36(12):800–7.
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Mototsugu, K. (2019). Japan. In: Shiotani, A. (eds) Gastric Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-13-1120-8_1
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DOI: https://doi.org/10.1007/978-981-13-1120-8_1
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