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A Review of Permanent Prostate Brachytherapy as Practiced in Japan

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Abstract

Iodine-125 permanent prostate brachytherapy (PPB) was introduced in Japan in 2003. The Japanese guidelines of radiation safety control for PPB regulate radiation safety parameters including the qualifications of the institutions and doctors to perform this treatment. To evaluate the safety and efficacy of PPB for localized prostate cancer, the nationwide Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 Seed Implantation (J-POPS) was conducted between 2005 and 2010. The J-POPS study is the largest multi-institutional prospective cohort study to achieve state-of-the-art clinical outcomes for localized prostate cancer treated using PPB. This study, along with regular training courses and joint radiation oncology-urology conferences, has promoted and achieves quality PPB. Every year, 3000 patients are treated with this modality in Japan. In this article, the early results of J-POPS and many clinical investigations are reviewed to provide the current status of PPB as practiced in Japan. This review covers planning techniques, postimplant dosimetry, toxicity, clinical outcomes, and special issues of radiation safety control.

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Author information

Authors and Affiliations

  1. Department of Radiation Oncology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan

    Atsunori Yorozu

  2. Department of Urology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan

    Shiro Saito

Authors
  1. Atsunori Yorozu
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  2. Shiro Saito
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Editors and Affiliations

  1. Radiation Oncology Department, The Cancer Institute Hospital of JFCR, Koto-ku, Tokyo, Japan

    Yasuo Yoshioka

  2. Department of Radiation Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan

    Jun Itami

  3. Radiation Oncology Department, The Cancer Institute Hospital of JFCR, Koto-ku, Tokyo, Japan

    Masahiko Oguchi

  4. Department of Radiation Oncology, Gunma University, Maebashi, Gunma, Japan

    Takashi Nakano

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Yorozu, A., Saito, S. (2019). A Review of Permanent Prostate Brachytherapy as Practiced in Japan. In: Yoshioka, Y., Itami, J., Oguchi, M., Nakano, T. (eds) Brachytherapy. Springer, Singapore. https://doi.org/10.1007/978-981-13-0490-3_12

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  • DOI: https://doi.org/10.1007/978-981-13-0490-3_12

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