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Neuropharmacology of Valeriana Genus

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Pharmacotherapeutic Potential of Natural Products in Neurological Disorders

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Abstract

Garden valerian and garden heliotrope are the common name for this species. The plant is native to certain parts of Asia and Europe and a member of Valerianaceae. However, it has been introduced into North America. It is worthwhile to note that the amino acid, valine, has been named after V. officinalis (Fig. 19.1).

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References

  • Becker A, Felgentreff F, Schröder H, Meier B, Brattström A. The anxiolytic effects of a valerian extract is based on valerenic acid. BMC Complement Altern Med. 2014;14:267.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Benke D, Barberis A, Kopp S, Altmann KH, Schubiger M, Vogt KE, Rudolph U, Möhler H. GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacology. 2009;56:174–81.

    Article  CAS  PubMed  Google Scholar 

  • Boeters U. Treatment of control disorders of the autonomic nervous system with valepotriate (Valmane). Munch Med Wochenschr. 1969;111:1873–6.

    PubMed  CAS  Google Scholar 

  • Castillo P, Zamilpa A, Márquez J, Hernández G, Lara M, Alvarez L. Comparative study of differentiation levels and valepotriate content of in vitro cultures and regenerated and wild plants of Valeriana edulis ssp. procera. J Nat Prod. 2002;65:573–5.

    Article  CAS  PubMed  Google Scholar 

  • Cavadas C, Araújo I, Cotrim MD, Amaral T, Cunha AP, Macedo T, Ribeiro CF. In vitro study on the interaction of Valeriana officinalis L. extracts and their amino acids on GABAA receptor in rat brain. Arzneimittelforschung. 1995;45:753–5.

    PubMed  CAS  Google Scholar 

  • Del Valle-Mojica LM, Ortíz JG. Anxiolytic properties of Valeriana officinalis in the zebrafish: a possible role for metabotropic glutamate receptors. Planta Med. 2012;78:1719–24.

    Article  CAS  PubMed  Google Scholar 

  • Dominguez RA, Bravo-Valverde RL, Kaplowitz BR, Cott JM. Valerian as a hypnotic for Hispanic patients. Cultur Divers Ethnic Minor Psychol. 2000;6:84–92.

    Article  CAS  PubMed  Google Scholar 

  • Donath F, Quispe S, Diefenbach K, Maurer A, Fietze I, Roots I. Critical evaluation of the effect of valerian extract on sleep structure and sleep quality. Pharmacopsychiatry. 2000;33:47–53.

    Article  CAS  PubMed  Google Scholar 

  • Dunaev VV, Trzhetsinskii SD, Tishkin VS, Fursa NS, Linenko VI. Biological activity of the sum of the valepotriates isolated from Valeriana alliariifolia. Farmakol Toksikol. 1987;50:33–7.

    PubMed  CAS  Google Scholar 

  • Dymchenko EI. Therapeutic dose of valerian tincture. Vrach Delo. 1969;7:141–2.

    PubMed  CAS  Google Scholar 

  • Felgentreff F, Becker A, Meier B, Brattström A. Valerian extract characterized by high valerenic acid and low acetoxy valerenic acid contents demonstrates anxiolytic activity. Phytomedicine. 2012;19:1216–22.

    Article  CAS  PubMed  Google Scholar 

  • Francis AJ, Dempster RJ. Effect of valerian, Valeriana edulis, on sleep difficulties in children with intellectual deficits: randomised trial. Phytomedicine. 2002;9:273–9.

    Article  CAS  PubMed  Google Scholar 

  • Haas LF. Neurological stamp. Valeriana officinalis (garden heliotrope). J Neurol Neurosurg Psychiatry. 1996;60:255.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hassani S, Alipour A, Darvishi Khezri H, Firouzian A, Emami Zeydi A, Gholipour Baradari A, Ghafari R, Habibi WA, Tahmasebi H, Alipour F, Ebrahim Zadeh P. Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial. Psychopharmacology. 2015;232:843–50.

    Article  CAS  PubMed  Google Scholar 

  • Hölzl J, Koch U. The compounds of Valeriana alliariifolia. Planta Med. 1984;50:458.

    Article  PubMed  Google Scholar 

  • Kieswetter R, Muller M. The sedative effect of valerian root. Pharmazie. 1958;13:777–81.

    Google Scholar 

  • Liu XG, Gao PY, Wang GS, Song SJ, Li LZ, Li X, Yao XS, Zhang ZX. In vivo antidepressant activity of sesquiterpenes from the roots of Valeriana fauriei Briq. Fitoterapia. 2012;83:599–603.

    Article  CAS  PubMed  Google Scholar 

  • Malva JO, Santos S, Macedo T. Neuroprotective properties of Valeriana officinalis extracts. Neurotox Res. 2004;6:131–40.

    Article  PubMed  Google Scholar 

  • Manson JS. The therapeutic value of valerian. Br Med J. 1928;10:842.

    Article  Google Scholar 

  • Müller LG, Salles LA, Stein AC, Betti AH, Sakamoto S, Cassel E, Vargas RF, von Poser GL, Rates SM. Antidepressant-like effect of Valeriana glechomifolia Meyer (Valerianaceae) in mice. Prog Neuro-Psychopharmacol Biol Psychiatry. 2012;36:101–9.

    Article  Google Scholar 

  • Müller LG, Borsoi M, Stolz ED, Herzfeldt V, Viana AF, Ravazzolo AP, Rates SM. Diene Valepotriates from Valeriana glechomifolia prevent lipopolysaccharide-induced sickness and depressive-like behaviour in mice. Evid Based Complement Alternat Med. 2015;2015:145914.

    Article  PubMed  PubMed Central  Google Scholar 

  • Neamati A, Chaman F, Hosseini M, Boskabady MH. The effects of Valeriana officinalis L. hydro-alcoholic extract on depression like behaviour in ovalbumin sensitized rats. J Pharm Bioallied Sci. 2014;6:97–103.

    PubMed  PubMed Central  Google Scholar 

  • Oliva I, González-Trujano ME, Arrieta J, Enciso-Rodríguez R, Navarrete A. Neuropharmacological profile of hydro alcohol extract of Valeriana edulis ssp. procera roots in mice. Phytother Res. 2004;18:290–6.

    Article  PubMed  Google Scholar 

  • Ortiz JG, Nieves-Natal J, Chavez P. Effects of Valeriana officinalis extracts on [3H]flunitrazepam binding, synaptosomal [3H]GABA uptake, and hippocampal [3H]GABA release. Neurochem Res. 1999;24:1373–8.

    Article  CAS  PubMed  Google Scholar 

  • Oshima Y, Matsuoka S, Ohizumi Y. Antidepressant principles of Valeriana fauriei roots. Chem Pharm Bull (Tokyo). 1995;43:169–70.

    Article  CAS  Google Scholar 

  • Pakseresht S, Boostani H, Sayyah M. Extract of valerian root (Valeriana officinalis L.) vs. placebo in treatment of obsessive-compulsive disorder: a randomized double-blind study. J Complement Integr Med. 2011;8. pii: /j/jcim.2011.8.issue-1/1553-3840.1465/1553-3840.1465.

    Google Scholar 

  • Peters FM. Autonomic dysfunction and its treatment with valerian. Hippokrates. 1953;24:567–70.

    PubMed  CAS  Google Scholar 

  • Sahu S, Ray K, Yogendra Kumar MS, Gupta S, Kauser H, Kumar S, Mishra K, Panjwani U. Valeriana wallichii root extract improves sleep quality and modulates brain monoamine level in rats. Phytomedicine. 2012;19:924–9.

    Article  PubMed  Google Scholar 

  • Salles LA, L Silva A, Rech SB, Zanatta N, von Poser GL. Constituents of Valeriana glechomifolia Meyer. Biochem Syst Ecol. 2000;28:907–10.

    Article  CAS  PubMed  Google Scholar 

  • Schulz H, Stolz C, Müller J. The effect of valerian extract on sleep polygraphy in poor sleepers: a pilot study. Pharmacopsychiatry. 1994;27:147–51.

    Article  CAS  PubMed  Google Scholar 

  • Sridharan S, Mohankumar K, Jeepipalli SP, Sankaramourthy D, Ronsard L, Subramanian K, Thamilarasan M, Raja K, Chandra VK, Sadras SR. Neuroprotective effect of Valeriana wallichii rhizome extract against the neurotoxin MPTP in C57BL/6 mice. Neurotoxicology. 2015;51:172–83.

    Article  CAS  PubMed  Google Scholar 

  • Sudati JH, Fachinetto R, Pereira RP, Boligon AA, Athayde ML, Soares FA, de Vargas Barbosa NB, Rocha JB. In vitro antioxidant activity of Valeriana officinalis against different neurotoxic agents. Neurochem Res. 2009;34:1372–9.

    Article  CAS  PubMed  Google Scholar 

  • Thies PW. Linarin-isovalerianate, a currently unknown flavonoid from Valeriana wallichii D.C. 6. Report on the active substances of Valeriana. Planta Med. 1968;16:363–71.

    Article  CAS  PubMed  Google Scholar 

  • Wasowski C, Marder M, Viola H, Medina JH, Paladini AC. Isolation and identification of 6-methylapigenin, a competitive ligand for the brain GABA(a) receptors, from Valeriana wallichii. Planta Med. 2002;68:934–6.

    Article  CAS  PubMed  Google Scholar 

  • Zhang ZX, Dou DQ, Liu K, Yao XS. Studies on the chemical constituents of Valeriana fauriei Briq. J Asian Nat Prod Res. 2006;8:397–400.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Herbal Consultant, Mohali, Punjab, India

    Amritpal Singh Saroya

  2. Department of Pharmacology, Sri Guru Ram Das Institute of Medical Science, Amritsar, Punjab, India

    Jaswinder Singh

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  1. Amritpal Singh Saroya
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  2. Jaswinder Singh
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Saroya, A.S., Singh, J. (2018). Neuropharmacology of Valeriana Genus. In: Pharmacotherapeutic Potential of Natural Products in Neurological Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-13-0289-3_19

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