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Modelling Details for Electric Field Simulations of Deep Brain Stimulation

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World Congress on Medical Physics and Biomedical Engineering 2018

Part of the book series: IFMBE Proceedings ((IFMBE,volume 68/1))

Abstract

Deep brain stimulation is a well-established technique for symptomatic treatment of e.g. Parkinson’s disease and essential tremor. Computer simulations using the finite element method (FEM) are widely used to estimate the affected area around the DBS electrodes. For the reliability of the simulations, it is important to match used simulation parameters with experimental data. One such parameter is the electric field magnitude threshold EFt required for axon stimulation. Another is the conductivity of the perielectrode space (PES) around the electrode. At the acute stage after surgery the PES will be characterized by an increased conductivity due to inflammation and edema while the later chronic stage will be characterized by a lower conductivity due to gliosis and minor scar formation. In this study, the EFt and the electric conductivity of the PES have been estimated by comparing FEM simulations with clinical studies of activation distance, pulse length and electrode impedance. The resulting estimates are an EFt of 0.2 V/mm at the common pulse width of 60 µs and a chronaxie of 62 µs. Estimated electric conductivities for the PES are 0.14 S/m in the acute stage and 0.05 S/m in the chronic stage, assuming a PES width of 250 µm. These values are thus experimentally justified to use in FEM simulations of DBS.

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Acknowledgements

This work is funded by the Swedish Research Council (Vetenskapsrådet, Dnr. 2016-03564), the Swedish Foundation for Strategic Research (Project BD15-0032), and the Knut and Alice Wallenberg Foundation (Project Seeing Organ Function). The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Linköping University, Linköping, Sweden

    Johannes D. Johansson, Fabiola Alonso & Karin Wårdell

Authors
  1. Johannes D. Johansson
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  2. Fabiola Alonso
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  3. Karin Wårdell
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Correspondence to Johannes D. Johansson .

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Editors and Affiliations

  1. CIIRC, Czech Technical University in Prague, Prague, Czech Republic

    Lenka Lhotska

  2. Institute of Clinical and Experimental Medicine, Prague, Czech Republic

    Lucie Sukupova

  3. Faculty of Electrical Engineering and Computing, University of Zagreb, Zagreb, Croatia

    Igor Lacković

  4. Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Geoffrey S. Ibbott

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Johansson, J.D., Alonso, F., Wårdell, K. (2019). Modelling Details for Electric Field Simulations of Deep Brain Stimulation. In: Lhotska, L., Sukupova, L., Lacković, I., Ibbott, G.S. (eds) World Congress on Medical Physics and Biomedical Engineering 2018. IFMBE Proceedings, vol 68/1. Springer, Singapore. https://doi.org/10.1007/978-981-10-9035-6_120

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  • DOI: https://doi.org/10.1007/978-981-10-9035-6_120

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