Abstract
Bacterial pathogens coordinate the expression of multiple virulence factors and formation of biofilms in cell density dependent manner, through a phenomenon named quorum sensing (QS). Protected in the biofilm community, bacterial cells resist the antibiotic treatment and host immune responses, ultimately resulting in difficult to treat infections. The high incidence of biofilm-related infections is a global concern related with increased morbidity and mortality in healthcare facilities, prolonged time of hospitalization and additional financial cost. This has led to the urgent need for innovative strategies to control bacterial diseases and drug resistance. In this review, we outline the disruption of QS pathways as a novel strategy for attenuation of bacterial virulence and prevention of resistant biofilms formation on medical devices and host tissues. Unlike the traditional antibiotics, inhibiting the QS signaling in bacteria will not kill the pathogen or affect its growth, but will block the targeted genes expression, making the cells less virulent and more vulnerable to host immune response and lower dosage of antimicrobials. We summarize the recent successes and failures in the development of novel anti-QS drugs as well as their application in controlling bacterial infections in healthcare facilities. The inhibitory targeting of the production of QS signals, their transduction and recognition by the other cells in the surrounding are discussed. Special focus is also given to the anti-QS nanomaterials with improved effectiveness and specificity towards the pathogens.
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References
Antunes LCM, Ferreira RBR, Buckner MMC, Finlay BB (2010) Quorum sensing in bacterial virulence. Microbiology 156:2271–2282. https://doi.org/10.1099/mic.0.038794-0
Bahari S, Zeighami H, Mirshahabi H, Roudashti S, Haghi F (2017) Inhibition of Pseudomonas aeruginosa quorum sensing by subinhibitory concentrations of curcumin with gentamicin and azithromycin. J Global Antimicrob Resis 10:21–28. https://doi.org/10.1016/j.jgar.2017.03.006
Bar-Rogovsky H, Hugenmatter A, Tawfik AS (2013) The evolutionary origins of detoxifying enzymes: the mammalian serum paraoxonases (PONs) relate to bacterial homoserine lactonases. J Biol Chem 288:23914–23927. https://doi.org/10.1074/jbc.M112.427922
Beceiro A, Tomás M, Bou G (2013) Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world? Clin Microbiol Rev 26:185–230. https://doi.org/10.1128/CMR.00059-12
Bijtenhoorn P, Mayerhofer H, Muller-Dieckmann J, Utpatel C, Schipper C, Hornung C, Szesny M, Grond S, Thurmer A, Brzuszkiewicz E, Daniel R, Dierking K, Schulenburg H, Streit WR (2011) A novel metagenomic short-chain dehydrogenase/reductase attenuates Pseudomonas aeruginosa biofilm formation and virulence on Caenorhabditis elegans. PLoS One 6:e26278. https://doi.org/10.1371/journal.pone.0026278
Bortolotti D, Le Maoult J, Trapella C, Di Luca D, Carosella ED, Rizzo R (2015) Pseudomonas aeruginosa quorum sensing molecule N-(3-oxododecanoyl)-L-homoserine-lactone induces HLA-G expression in human immune cells. Infect Immun 83:3918–3925. https://doi.org/10.1128/IAI.00803-15
Brackman G, Cos P, Maes L, Nelis HJ, Coenye T (2011) Quorum sensing inhibitors increase the susceptibility of bacterial biofilms to antibiotics in vitro and in vivo. Antimicrob Agents Chemother 55:2655–2661. https://doi.org/10.1128/AAC.00045-11
Brackman G, Breyne K, De Rycke R, Vermote A, Van Nieuwerburgh F, Meyer E, Van Calenbergh S, Coenye T (2016) The quorum sensing inhibitor hamamelitannin increases antibiotic susceptibility of Staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release. Sci Rep 6:20321. https://doi.org/10.1038/srep20321
Broderick A, Stacy DM, Tal-Gan Y, Kratochvil MJ, Blackwell HE, Lynn DM (2014) Surface coatings that promote rapid release of peptide-based agrC inhibitors for attenuation of quorum sensing in Staphylococcus aureus. Adv Healthc Mater 3:97–105. https://doi.org/10.1002/adhm.201300119
Cao Y, He S, Zhou Z, Zhang M, Mao W, Zhang H, Yao B (2012) Orally administered thermostable N-Acyl homoserine lactonase from bacillus sp. strain ai96 attenuates aeromonas hydrophila infection in zebrafish. Appl Environ Microbiol 78:1899–1908. https://doi.org/10.1128/AEM.06139-11
Chang CY, Krishnan T, Wang H, Chen Y, Yin W-F, Chong Y-M, Tan LY, Chong TM, Chan K-G (2014) Non-antibiotic quorum sensing inhibitors acting against N -acyl homoserine lactone synthase as drug gable target. Sci Rep 4:7245. https://doi.org/10.1038/srep07245
Cheng G, Hao H, Xie S, Wang X, Dai M, Huang L, Yuan Z (2014) Antibiotic alternatives: the substitution of antibiotics in animal husbandry? Front Microbiol 5:217. https://doi.org/10.3389/fmicb.2014.00217
Cheung GYC, Joo HS, Chatterjee SS, Otto M (2014) Phenol-soluble modulins – critical determinants of staphylococcal virulence. FEMS Microbiol Rev 38:698–719. https://doi.org/10.1111/1574-6976.12057
Christensen LD, Van Gennip M, Jakobsen TH, Alhede M, Hougen HP, Høiby N, Bjarnsholt T, Givskov M (2012) Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model. J Antimicrob Chemother 67:1198–1206. https://doi.org/10.1093/jac/dks002
Cirioni O, Ghiselli R, Minardi D, Orlando F, Mocchegiani F, Silvestri C, Muzzonigro G, Saba V, Scalise G, Balaban N, Giacometti A (2007) RNAIII-inhibiting peptide affects biofilm formation in a rat model of staphylococcal ureteral stent infection. Antimicrob Agents Chemother 51:4518–4520. https://doi.org/10.1128/AAC.00808-07
Czajkowski R, Krzyzanowska D, Karczewska J, Atkinson S, Przysowa S, Lojkowska E, Williams P, Jafra S (2011) Inactivation of AHLs by Ochrobactrum Sp. A44 depends on the activity of a novel class of AHL acylase. Environ Microbiol Rep 3:59–68. https://doi.org/10.1111/j.1758-2229.2010.00188
De Lamo Marin S, Xu Y, Meijler MM, Janda KD (2007) Antibody catalyzed hydrolysis of a quorum sensing signal found in Gram-negative bacteria. Bioorg Med Chem Lett 17:1549–1552. https://doi.org/10.1016/j.bmcl.2006.12.118
Dey D, Ghosh S, Ray R, Hazra B (2016) Polyphenolic secondary metabolites synergize the activity of commercial antibiotics against clinical isolates of β-lactamase-producing Klebsiella pneumoniae. Phytother Res 30:272–282. https://doi.org/10.1002/ptr.5527
Dong YH, Wang LH, Xu JL, Zhang HB, Zhang XF, Zhang LH (2001) Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase. Nature 411:813–817. https://doi.org/10.1038/35081101
Fernandes MM, Ivanova K, Francesko A, Rivera D, Burgues J-T, Gedanken A, Mendonza E, Tzanov T (2016) Escherichia coli and Pseudomonas aeruginosa eradication by nano-penicillin G. Nanomed: Nanotechnol Biol Med 12:2061–2069. https://doi.org/10.1016/j.nano.2016.05.018
Fernandes MM, Ivanova K, Hoyo J, Pérez-Rafael S, Francesko A, Tzanov T (2017) Nanotransformation of vancomycin overcomes the intrinsic resistance of Gram-negative bacteria. ACS Appl Mater Interfaces 9:15022–15030. https://doi.org/10.1021/acsami.7b00217
Francesko A, Fernandes MM, Ivanova K, Amorimb S, Reis RL, Pashkuleva I, Mendozad E, Pfeifer A, Heinze T, Tzanov T (2016) Bacteria-responsive multilayer coatings comprising polycationic nanospheres for bacteria biofilm prevention on urinary catheters. Acta Biomater 33:203–212. https://doi.org/10.1016/j.actbio.2016.01.020
Furiga A, Lajoie B, El Hage S, Baziard G, Roques C (2016) Impairment of Pseudomonas aeruginosa biofilm resistance to antibiotics by combining the drugs with a new quorum-sensing inhibitor. Antimicrob Agents Chemother 60:1676–1686. https://doi.org/10.1128/AAC.02533-15
Galloway WRJD, Hodgkinson TJ, Bowden SD, Welch M, Spring DR (2011) Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways. Chem Rev 111:28–67. https://doi.org/10.1021/cr100109t
Gamby S, Roy V, Guo M, Smith JAI, Wang J, Stewart JE, Wang X, Bentley WE, Sintim HO (2012) Altering the communication networks of multispecies microbial systems using a diverse toolbox of AI-2 analogues. ACS Chem Biol 7:1023–1030. https://doi.org/10.1021/cb200524y
García-Lara B, Saucedo-Mora MA, Roldan-Sanchez JA, Perez-Eretza B, Ramasamy M, Lee J, Coria-Jimenez R, Tapia M, Varela-GuerreroV G-CR (2015) Inhibition of quorum-sensing-dependent virulence factors and biofilm formation of clinical and environmental Pseudomonas aeruginosa strains by ZnO nanoparticles. Lett Appl Microbiol 61:299–305. https://doi.org/10.1111/lam.12456
Geske GD, Mattmann ME, Blackwell HE (2008) Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators. Bioorg Med Chem Lett 18:5978–5981. https://doi.org/10.1016/j.bmcl.2008.07.089
Grant SS, Hung DT (2013) Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response. Virulence 4:273–283. https://doi.org/10.4161/viru.23987
Gray B, Hall P, Gresham H (2013) Targeting agr- and agr-like quorum sensing systems for development of common therapeutics to treat multiple Gram-positive bacterial infections. Sensors 13:5130–5166. https://doi.org/10.3390/s130405130
Grover N, Plaks JG, Summers SR, Chado GR, Schurr MJ, Kaar JL (2016) Acylase-containing polyurethane coatings with anti-biofilm activity. Biotechnol Bioeng 113:2535–2543. https://doi.org/10.1002/bit.26019
Gupta P, Chhibber S, Harjai K (2015) Efficacy of purified lactonase and ciprofloxacin in preventing systemic spread of Pseudomonas aeruginosa in murine burn wound model Burns. Burns 41:153e162. https://doi.org/10.1016/j.burns.2014.06.009
Hawver LA, Jung SA, Ng W-L (2016) Specificity and complexity in bacterial quorum-sensing systems. FEMS Microbiol Rev 40:738–752. https://doi.org/10.1093/femsre/fuw014
Hema M, AdlinePrincy S, Sridharan V, Vinoth P, Balamurugan P, Sumana MN (2016) Synergistic activity of quorum sensing inhibitor, pyrizine-2-carboxylic acid and antibiotics against multi-drug resistant: V. cholerae. RSC Adv 6:45938–45946. https://doi.org/10.1039/c6ra04705j
Hentzer M, Givskov M (2003) Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections. J Clin Invest 112:1300–1307. https://doi.org/10.1172/JCI200320074
Hong K-W, Koh C-L, Sam C-K, Yin W-F, Chan K-G (2012) Quorum quenching revisited-from signal decays to signalling confusion. Sensors 12:4661–4696. https://doi.org/10.3390/s120404661
Huang JJ, J-In H, Zhang L-H, Leadbetter JR (2003) Utilization of acyl-homoserine lactone quorum signals for growth by a soil pseudomonad and Pseudomonas aeruginosa PAO1. Appl Environ Microbiol 69:5941–5949. https://doi.org/10.1128/AEM.69.10.5941
Ilk S, Saglamb N, Özgenc M, Korkusuz F (2017) Chitosan nanoparticles enhances the anti-quorum sensing activity of kaempferol. Int J Biol Macromol 94:653–662. https://doi.org/10.1016/j.ijbiomac.2016.10.068
Ivanova K, Fernandes MM, Tzanov T (2013) In: Mendez-Vilas A (ed) Current advances on bacterial pathogenesis inhibition and treatment strategies. Microbial pathogens and strategies for combating them: science, technology and education, vol 1. Formatex Research Center, Badajoz, pp 322–336
Ivanova K, Fernandes MM, Francesko A, Mendoza E, Guezguez J, Burnet M, Tzanov T (2015a) Quorum-quenching and matrix-degrading enzymes in multilayer coatings synergistically prevent bacterial biofilm formation on urinary catheters. ACS Appl Mater Interfaces 7:27066–27077. https://doi.org/10.1021/acsami.5b09489
Ivanova K, Fernandes MM, Mendoza E, Tzanov T (2015b) Enzyme multilayer coatings inhibit Pseudomonas aeruginosa biofilm formation on urinary catheters. Appl Microbiol Biotechnol 99:4373–4385. https://doi.org/10.1007/s00253-015-6378-7
Jabra-Rizk MA, Meiller TF, James CE, Shirtliff ME (2006) Effect of farnesol on Staphylococcus aureus biofilm formation and antimicrobial susceptibility. Antimicrob Agents Chemother 50:1463–1469. https://doi.org/10.1128/AAC.50.4.1463–1469.2006
Kai K, Fujii H, Ikenaka R, Akagawa M, Hayashi H (2014) An acyl-SAM analog as an affinity ligand for identifying quorum sensing signal synthases. Chem Commun 50:8586–8589. https://doi.org/10.1039/c4cc03094j
Kalia VC (2015) Microbes: the most friendly beings? In: Kalia VC (ed) Quorum sensing vs quorum quenching: a battle with no end in sight. Springer India, pp 1–5. https://doi.org/10.1007/978-81-322-1982-8_1. ISBN 978-81-322-1981-1
Kasper SH, Hart R, Bergkvist M, Musah RA, Cady NC (2016) Zein nanocapsules as a tool for surface passivation, drug delivery and biofilm prevention. AIMS Microbiol 2:422–433. https://doi.org/10.3934/microbiol.2016.4.422
Kaufmann GF, Park J, Mee JM, Ulevitch RJ, Janda KD (2008) The quorum quenching antibody RS2-1G9 protects macrophages from the cytotoxic effects of the Pseudomonas aeruginosa quorum sensing signalling molecule N-3-oxo-dodecanoyl-homoserine lactone. Mol Immunol 45:2710–2714. https://doi.org/10.1016/j.molimm.2008.01.010
Khan BA, Yeh AJ, Cheung GYC, Otto M (2015) Investigational therapies targeting quorum-sensing for the treatment of Staphylococcus aureus infections. Informa Healthcare 24:1–16. https://doi.org/10.1517/13543784.2015.1019062
Kim H-S, Lee S-H, Byun Y, Park H-D (2015) 6-gingerol reduces Pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition. Sci Rep 5:8656. https://doi.org/10.1038/srep08656
Kiran S, Sharma P, Harjai K, Capalash N (2011) Enzymatic quorum quenching increases antibiotic susceptibility of multidrug resistant Pseudomonas aeruginosa. Iran J Microbiol 3:1–12
Koch G, Nadal-Jimeneza P, Reisa CR, Muntendama R, Bokhoveb M, Melilloa E, Dijkstrab BW, Coola RH, Quax WJ (2014) Reducing virulence of the human hathogen Burkholderia by altering the substrate specificity of the quorum-quenching Acylase PvdQ. Proc Nat Acad Sci 111:1568–1573. https://doi.org/10.1073/pnas.1311263111
Kuo D, Yu G, Hoch W, Gabay D, Long L, Ghannoum M, Nagy N, Harding CV, Viswanathan R, Shoham M (2015) Novel quorum-quenching agents promote methicillin-resistant Staphylococcus aureus (mrsa) wound healing and sensitize mrsa to β-lactam antibiotics. Antimicrob Agents Chemother 59:1512–1518. https://doi.org/10.1128/AAC.04767-14
Lade H, Paul D, Kweon JH (2014) Quorum quenching mediated approaches for control of membrane biofouling. Int J Biol Sci 10:550–565. https://doi.org/10.7150/ijbs.9028
LaSarre B, Federle MJ (2013) Exploiting quorum sensing to confuse bacterial pathogens. Microbiol Mol Biol Rev 77:73–111. https://doi.org/10.1128/MMBR.00046-12
Le KY, Otto M (2015) Quorum-sensing regulation in staphylococci-an overview. Front Microbiol 6:1174. https://doi.org/10.3389/fmicb.2015.01174
Lee J, Zhang L (2014) The hierarchy quorum sensing network in Pseudomonas aeruginosa. Protein Cell 6:26–41. https://doi.org/10.1007/s13238-014-0100-x
Lee K, Lee J-H, Kim S-I, Cho MH, Lee J (2014) Anti-biofilm, anti-hemolysis, and anti-virulence activities of black pepper, cananga, myrrh oils, and nerolidol against Staphylococcus aureus. Appl Microbiol Biotechnol 98:9447–9457. https://doi.org/10.1007/s00253-014-5903-4
Lee J, Lee I, Nam J, Hwang DS, Yeon K-M, Kim J (2017) Immobilization and stabilization of acylase on carboxylated polyaniline nanofibers for highly effective antifouling application via quorum quenching. ACS Appl Mater Interfaces 9:15424–15432. https://doi.org/10.1021/acsami.7b01528
Li Z, Nair SK (2012) Quorum sensing: how bacteria can coordinate activity and synchronize their response to external signals? Protein Sci 21:1403–1417. https://doi.org/10.1002/pro.2132
Lin YH, Xu J-L, Hu J, Wang L-H, Ong SL, Leadbetter JR, Zhang L-H (2003) Acyl-homoserine lactone acylase from Ralstonia strain XJ12B represents a novel and potent class of quorum-quenching enzymes. Mol Microbiol 47:849–860. https://doi.org/10.1046/j.1365-2958.2003.03351.x
Loughlin CTO, Miller LC, Siryaporn A, Drescher K, Semmelhack MF (2013) A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation. Proc Natl Acad Sci U S A 110:17981–17986. https://doi.org/10.1073/pnas.1316981110
Miller KP, Wang L, Chen Y-P, Pellechia PJ, Benicewicz BC, Decho AW (2015) Engineering nanoparticles to silence bacterial communication. Front Microbiol 6:189. https://doi.org/10.3389/fmicb.2015.00189
Miquel S, Lagrafeuille R, Souweine B, Forestier C (2016) Anti-biofilm activity as a health issue. Front Microbiol 7:592. https://doi.org/10.3389/fmicb.2016.00592
Monnet V, Juillard V, Gardan R (2016) Peptide conversations in Gram-positive bacteria. Crit Rev Microbiol 42:339–351. https://doi.org/10.3109/1040841X.2014.948804
Montebello NA, Brecht RM, Turner DR, Ghali M, Pu X, Nagarajan R (2014) Acyl-ACP substrate recognition in Burkholderia mallei BmaI1 acyl-homoserine lactone synthase. ACS Biochem 53:6231–6242. https://doi.org/10.1021/bi5009529
Munita JM, Arias CA (2016) Mechanism of antibiotic resistance. Microbiol Spectr 4:1–37. https://doi.org/10.1128/microbiolspec.VMBF-0016-2015
Nafee N, Husari A, Maurer CK, Lu C, de Rossi C, Steinbach A, Hartmann RW, Lehr C-M, Schneider M (2014) Antibiotic-free nanotherapeutics: ultra-small, mucus-penetrating solid lipid nanoparticles enhance the pulmonary delivery and anti-virulence efficacy of novel quorum sensing inhibitors. J Control Release 192:131–140. https://doi.org/10.1016/j.jconrel.2014.06.055
Packiavathy AISV, Priya S, Karutha Pandian SK, Ravi AV (2014) Inhibition of biofilm development of uropathogens by curcumin – an anti-quorum sensing agent from Curcuma longa. Food Chem 148:453–460. https://doi.org/10.1016/j.foodchem.2012.08.002
Paczkowski JE, Mukherjee S, McCready AR, Cong J-P, Aquino CJ, Kim H, Henke BR, Smith CD, Bassler BL (2017) Flavonoids suppress Pseudomonas aeruginosa virulence through allosteric inhibition of quorum-sensing receptors. J Biol Chem 292:4064–4076. https://doi.org/10.1074/jbc.M116.770552
Papenfort K, Bassler B (2015) Quorum-sensing signal-response systems in Gram-negative bacteria. Nat Rev Microbiol 510:84–91. https://doi.org/10.1038/nrmicro.2016.89
Park J, Jagasia R, Kaufmann GF, Mathison JC, Ruiz DI, Moss JA, Meijler MM, Ulevitch RJ, Janda KD (2007) Infection control by antibody disruption of bacterial quorum sensing signaling. Chem Biol 14:1119–1127. https://doi.org/10.1016/j.chembiol.2007.08.013
Percival SL, Suleman L, Vuotto C, Donelli G (2015) Healthcare-associated infections, medical devices and biofilms: risk, tolerance and control. J Med Microbiol 64:323–334. https://doi.org/10.1099/jmm.0.000032
Pollitt EJG, West SA, Crusz SA, Burton-Chellew MN, Diggle SP (2014) Cooperation, quorum sensing, and evolution of virulence in Staphylococcus aureus. Infect Immun 82:1045–1051. https://doi.org/10.1128/IAI.01216-13
Pustelny C, Albers A, Buldt-Karentzopoulos K, Parschat K, Chhabra SR, Camara M, Williams P, Fetzner S (2009) Dioxygenase-mediated quenching of quinolone-dependent quorum sensing in Pseudomonas aeruginosa. Chem Biol 16:1259–1267. https://doi.org/10.1016/j.chembiol.2009.11.013
Rampioni G, Leoni L, Williams P (2014) The art of antibacterial warfare: deception through interference with quorum sensing-mediated communication. Bioorg Chem 55:60–68. https://doi.org/10.1016/j.bioorg.2014.04.005
Reuter K, Steinbach A, Helms V (2016) Interfering with bacterial quorum sensing. Perspect Medicin Chem 8:1–15. https://doi.org/10.4137/PMC.S13209
Rezzonico F, Smits THM, Duffy B (2012) Detection of AI-2 receptors in genomes of Enterobacteriaceae suggests a role of type-2 quorum sensing in closed ecosystems. Sensors (Switzerland) 12:6645–6665. https://doi.org/10.3390/s120506645
Römling U, Balsalobre C (2012) Biofilm infections, their resilience to therapy and innovative treatment strategies. J Intern Med 272:541–561. https://doi.org/10.1111/joim.12004
Scott R, Hasty J (2016) Quorum sensing communication modules for microbial consortia. ACS Synth Biol 5:969–977. https://doi.org/10.1021/acssynbio.5b00286
Singh BR, Singh BN, Singh A, Khan W, Naqvi AH, Singh HB (2015) Mycofabricated biosilver nanoparticles interrupt Pseudomonas aeruginosa quorum sensing systems. Sci Rep 5:13719. https://doi.org/10.1038/srep13719
Singh BN, Prateeksha, Upreti DK, Singh BR, Defoirdt T, Gupta VK, De Souza AO, Singh HB, Barreira JCM, Ferreira ICFR, Vahabi K (2017) Bactericidal, quorum quenching and anti-biofilm nanofactories: a new niche for nanotechnologists. Crit Rev Biotechnol 37:525–540. https://doi.org/10.1080/07388551.2016.1199010
Sully EK, Malachowa N, Elmore BO, Alexander SM, Femling JK, Gray BM, DeLeo FR, Otto M, Cheung AL, Edwards BS, Sklar LA, Horswill AR, Hall PR, Gresham HD (2014) Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance. PLoS Pathog 10:e1004174. https://doi.org/10.1371/journal.ppat.1004174
Tan CH, Koh KS, Xie C, Zhang J, Tan XH, Lee GP, Zhou Y, Ng WJ, Rice SA, Kjelleberg S (2015) Community quorum sensing signalling and quenching: microbial granular biofilm assembly. NPJ Biofilms Microbiomes 1:15006. https://doi.org/10.1038/npjbiofilms.2015.6
Tang K, Su Y, Brackman G, Cui F, Zhang Y, Shi X, Coenye T, Zhang X-H (2015) MomL, a novel marine-derived N-acyl homoserine lactonase from Muricauda olearia. Appl Environ Microbiol 81:774–782. https://doi.org/10.1128/AEM.02805-14
Taraszkiewicz A, Fila G, Grinholc M, Nakonieczna J (2013) Innovative strategies to overcome biofilm resistance. Biomed Res Int 13:150653. https://doi.org/10.1155/2013/150653
Tay SB, Wen Yew WS (2013) Development of quorum-based anti-virulence therapeutics targeting Gram-negative bacterial pathogens. Int J Mol Sci 14:16570–16599. https://doi.org/10.3390/ijms140816570
Tong SYC, Chen LF, Fowler VG Jr (2013) Colonization, pathogenicity, host susceptibility and therapeutics for Staphylococcus aureus: what is the clinical relevance? Semin Immunopathol 34:185–200. https://doi.org/10.1007/s00281-011-0300-x
Uroz S, Chhabra SR, Camara M, Williams P, Oger P, Dessaux Y (2005) N-acylhomoserine lactone quorum-sensing molecules are modified and degraded by Rhodococcus erythropolis W2 by both amidolytic and novel oxidoreductase activities. Microbiology 151:3313–3322. https://doi.org/10.1099/mic.0.27961-0
Vinoj G, Vaseeharan B, Thomas S, Spiers AJ, Shanthi S (2014) Quorum-quenching activity of the AHL-lactonase from Bacillus licheniformis DAHB1 inhibits Vibrio biofilm formation in vitro and reduces shrimp intestinal colonisation and mortality. Mar Biotechnol 16:707–715. https://doi.org/10.1007/s10126-014-9585-9
Vinoj G, Patib R, Sonawaneb A, Baskaralingam V (2015) In vitro cytotoxic effects of gold nanoparticles coated with functional acyl homoserine lactone lactonase protein from Bacillus licheniformis and their antibiofilm activity against Proteus species. Antimicrob Agents Chemother 59:763–771. https://doi.org/10.1128/AAC.03047-14
Weiland-Bräuer N, Kisch MJ, Pinnow N, Liese A, Schmitz RA (2016) Highly effective inhibition of biofilm formation by the first metagenome-derived AI-2 quenching enzyme. Front Microbiol 7:1098. https://doi.org/10.3389/fmicb.2016.01098
Xue T, Zhao L, Sun B (2012) LuxS/AI-2 system is involved in antibiotic susceptibility and autolysis in Staphylococcus aureus NCTC 8325. Int J Antimicrob Agents 41:85–89. http://dx.doi.org/10.1016/j.ijantimicag.2012.08.016
Yang YX, Xu Z-H, Zhang Y-Q, Tian J, Weng L-X, Wang L-H (2012) A new quorum-sensing inhibitor attenuates virulence and decreases antibiotic resistance in Pseudomonas aeruginosa. J Microbiol 50:987–993. https://doi.org/10.1007/s12275-012-2149-7
Yerushalmi SM, Buck ME, Lynn DM, Gabriel N, Meijler MM (2013) Multivalent alteration of quorum sensing in Staphylococcus aureus. Chem Commun 49:5177–5179. https://doi.org/10.1039/c3cc41645c
Zang T, Lee BK, Cannonb LM, Ritterb KA, Daia S, Renc D, Wood TK, Zhou ZS (2010) A naturally occurring brominated furanone covalently modifies and inactivates LuxS. Bioorg Med Chem Lett 19:6200–6204. https://doi.org/10.1016/j.bmcl.2009.08.095
Zhang Y, Brackman G, Coenye T (2017) Pitfalls associated with evaluating enzymatic quorum quenching activity: the case of MomL and its effect on Pseudomonas aeruginosa and Acinetobacter baumannii biofilms. PeerJ 5:e3251. https://doi.org/10.7717/peerj.3251
Acknowledgements
This work was supported by the European project PROTECT – “Pre-commercial lines for production of surface nanostructured antimicrobial and anti-biofilm textiles, medical devices and water treatment membranes” (H2020 – 720851). A. I. wish to acknowledge Generalitat de Catalunya for providing her Ph.D. grant (2017FI_B_00524).
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Ivanova, A., Ivanova, K., Tzanov, T. (2018). Inhibition of Quorum-Sensing: A New Paradigm in Controlling Bacterial Virulence and Biofilm Formation. In: Kalia, V. (eds) Biotechnological Applications of Quorum Sensing Inhibitors. Springer, Singapore. https://doi.org/10.1007/978-981-10-9026-4_1
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