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Functional Nucleic Acid Biosensors for Small Molecules

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Functional Nucleic Acid Based Biosensors for Food Safety Detection

Abstract

Functional nucleic acid including aptamer, DNAzyme, and triplex DNA has inspired increasing researchers’ attention due to variability and specificity of sequence and potential in biosensor fabrication. Especially, the rapid development of aptamer SELEX technique for small molecules makes a significant contribution to the recognition of small molecules. This highly specific affinity could finally be transduced into an electrochemical or optical signal output for a quantitative determination. Moreover, a variety of nanomaterials such as AuNPs, carbon nanotubes, graphene, and carbon black have been exploited to be modified onto the surface of biosensor for ultrasensitive detection. Additionally, the combination of nucleic acid amplification technique and aptamer is also an effective approach to improve the sensitivity of biosensor. It promises the promotion of aptasensors in performance toward a new level. In this chapter, we will review the functional nucleic acid biosensors for small molecules except heavy metal mentioned at previous chapter.

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    Yunbo Luo

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Luo, Y. (2018). Functional Nucleic Acid Biosensors for Small Molecules. In: Functional Nucleic Acid Based Biosensors for Food Safety Detection. Springer, Singapore. https://doi.org/10.1007/978-981-10-8219-1_10

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