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Glycyrrhetinic Acid

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Abstract

Glycyrrhetinic acid is extracted from liquorice, which is an important compound in liquorice. Glycyrrhetinic acid plays a role in anti-inflammatory, antiulcer activity, and antioxidation. Glycyrrhetinic acid also has an antiviral effect, antitumor effect, and antiarrhythmic effects. In addition, glycyrrhetinic acid functions as an anticholinesterase, anticoagulant, anti-tetanus toxin; it also improves inner ear hearing and improves absorption of insulin. However, its pseudoaldosteronism effect restricts clinical application, and it needs further study to develop new drugs.

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References

  1. Ruzicka L, Leuenberger H, Schellenberg H. Polyterpene und Polyterpenoide CXVIII. Katalytische Hydrierung der α, β-ungesättigten Ketogruppe in der Glycyrrhetinsäure und dem Keto-α-amyrin. Helv Chim Acta. 1937;20(1):1271–9.

    Article  CAS  Google Scholar 

  2. Doppelbindungen EV. Zur Lage der Carboxylgruppe bei der Glycyrrhetinsäure. Helv Chim Acta. 1942;25:775.

    Article  Google Scholar 

  3. Ruzicka L, Jeger O, Ingold W. Neuer Beweis für die verschiedene Lage der Carboxylgruppe bei der Oleanolsäure und der Glycyrrhetinsäure. Helv Chim Acta. 1943;26:2278–82.

    Article  CAS  Google Scholar 

  4. Rovers F. Effect of antiulcer of glycyrrhetic acid. Tijdschr Geneesk. 1946;90(12):135.

    Google Scholar 

  5. Li B, Jiang T, Wan SB. Progress in chemical modification and structure transformation of glycyrrhetic acid. Fine Chem. 2006;23:643–8.

    CAS  Google Scholar 

  6. Kang L, Li XQ, Wang FR. Advances in studies on structural modifications and biological activities of 18β-glycyrrhetinic acid. Chin Tradit Herb Drug. 2012;43:1430–42.

    CAS  Google Scholar 

  7. Gao K, Wei Y, Yang J. CYP3A1/2 and 2C9/10 in rat liver microsomes mediate 22α-and 24- hydroxylation of 18α-glycyrrhetic acid. Chin J Clin Pharmacol Ther. 2008;12:1255–60.

    Google Scholar 

  8. Xie SR, Zhao J, Liu R. Study and expectation of glycyrrhetic acid. J Dalian Univ. 2005;26:85–8.

    Google Scholar 

  9. Jin M, Wu HJ. Advancement on pharmacological action of glycyrrhetic acid. Med Recapitulate. 2009;15:1712–5.

    Google Scholar 

  10. Yang JN, Zhu M. Review of pharmacology of glycyrrhetinic acid and derivatives. Chin Pharmacol Bull. 1997;13:110–4.

    CAS  Google Scholar 

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Correspondence to Guan-Hua Du .

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© 2018 Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China

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Zhang, W., Zhou, QM., Du, GH. (2018). Glycyrrhetinic Acid. In: Natural Small Molecule Drugs from Plants. Springer, Singapore. https://doi.org/10.1007/978-981-10-8022-7_67

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