Skip to main content

Morphine

  • Chapter
  • First Online:

Abstract

Morphine is extracted from poppy, which is the most important alkaloid in opium. Morphine has a strong analgesic effect, especially for moderate and severe cancer pain. However, morphine has serious side effects, such as addiction, respiratory depression, acute poisoning, and death. Therefore, in regulating the clinical application of morphine, it is necessary to explore the alternative to morphine with strong analgesic role and minor side effects. In the long history of morphine R&D, there are many opioid drugs to be found and they make great contributions for the treatment of pain and human disease. Therefore, it is the ultimate goal to develop new drugs by applying advanced technology and protect human health, as far as possible to reduce possible harm.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Brownstein MJ. A brief history of opiates, opioid peptides, and opioid receptor. Proc Natl Acad Sci U S A. 1993;90:5391–3.

    Article  CAS  Google Scholar 

  2. Gates M, Tschudi G. The synthesis of morphine. J Am Chem Soc. 1952;74:1109–0.

    Article  CAS  Google Scholar 

  3. Novak BH, Hudlicky T, Reed JW, et al. Morphine synthesis and biosynthesis – an update. Curr Org Chem. 2000;4:343–62.

    Article  CAS  Google Scholar 

  4. Serturner FW. Trommsdorff’s Journal der Pharmazie fur Aerzte. Apotheker und Chemisten. 1806;14:47–93.

    Google Scholar 

  5. Serturner FW. Ueber das Morphium, eine neue salzfahige Grundlage, und die Mekonsaure, als Hauptbestandtheile des Opiums. Gilbert’s Annalen der Physik. 1817;55:56–89.

    Article  Google Scholar 

  6. Eisleb O, Schaumann O. Dolantain, a new antispasmodic and analgesic. Deut Med Wochschr. 1939;65:967–8.

    Article  CAS  Google Scholar 

  7. Scott CC, Chen KK. The action of 1,1-diphenyl-1(dimethylaminoisopropyl) butanone-2, a potent analgesic agent. J Pharmacol Exp Ther. 1946;87:63–71.

    CAS  PubMed  Google Scholar 

  8. Preston KL, Jasinski DR, Testa M. Abuse potential and pharmacological comparison of tramadol and morphine. Drug Alcohol Depend. 1991;27:7–17.

    Article  CAS  Google Scholar 

  9. Trescot AM, Datta S, Lee M, Hansen H. Opioid pharmacology. Pain Physician. 2008;11(2 Suppl):S133–53.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Guan-Hua Du .

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Kong, LL., Wang, JH., Du, GH. (2018). Morphine. In: Natural Small Molecule Drugs from Plants. Springer, Singapore. https://doi.org/10.1007/978-981-10-8022-7_49

Download citation

Publish with us

Policies and ethics