Abstract
Ligustrazine is extracted from chuanxiong 川芎 (Ligusticum chuanxiong Hort; L. wallichii), which is the most important alkaloid in chuanxiong. Studies have demonstrated that ligustrazine is effective at promoting blood flow, the circulation of Qi, and the removal of blood stasis, so it has been extensively used to treat ischemic cardiovascular and cerebrovascular diseases, such as atherosclerosis, hypertension, and stroke. Ligustrazine has also used to treat children with viral myocarditis, chronic renal failure, hepatic fibrosis, portal hypertension, tumors, and diabetic nephropathy. Ligustrazine can relieve symptoms rapidly, and its effect is stable and lasting. It has good spread of the value in clinic. To decide the specificity of ligustrazine used in clinic, we carried out a large-sample, multicenter, randomized, double-blind, placebo-controlled trial, which provides evidences for the extensive use of ligustrazine in clinic.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Jia L, Sun X. Research progress of Chinese herbal medicine Ligusticum Wallichii. Heilongjiang Sci Technol Inform. 2009;11:146–7.
Kosuge T, Kamiya H. Discovery of a pyrazine in a natural product: tetramethylpyrazine from cultures of a strain of Bacillus subtilis. Nature. 1962;193:776.
Chen K, Qian Z, Zhang W, et al. Efficacy of Ligustrazine in the treatment of acute occlusive cerebrovascular disease. Report on coordination meeting of ligustrazine in Beijing 1975.
Jiang F, Qian J, Chen S, et al. Ligustrazine improves atherosclerosis in rat via attenuation of oxidative stress. Pharm Biol. 2011;49(8):856–63.
Tan F, Fu W, Cheng N, et al. Ligustrazine reduces blood-brain barrier permeability in a rat model of focal cerebral ischemia and reperfusion. Exp Ther Med. 2015;9(5):1757–62.
Jiang Y, Chen K. Pharmacological effects and clinical application of ligustrazine on cardiovascular and cerebrovascular diseases. Chin J Integr Tradit West Med. 2013;33(5):707–11.
Wu W. The clinical curative effect of Ligustrazine and citicoline sodium combined with diphenhydramine hydrochloride in treatment of vertigo syndrome. China Mod Med. 2011;18(4):51–5.
Li X, Chen Y. Efficacy of ligustrazine in the treatment of tension headache. Chin J Pract Nerv Dis. 2010;13(18):64–5.
Dong M, Li Y, Ge N, et al. Curative efficacy of Qingxuan decoction combined with ligustrazine injection in the treatment of vertebrobasilar insufficiency. Beijing J Tradit Chin Med. 2011;30(1):8–10.
Peng X. Efficacy of ligustrazine injection in treatment of viral myocarditis in children. J Youjiang Med Univ Natl. 2010;3:376–7.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2018 Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China
About this chapter
Cite this chapter
He, GR., Wang, Sb., Du, GH. (2018). Ligustrazine. In: Natural Small Molecule Drugs from Plants. Springer, Singapore. https://doi.org/10.1007/978-981-10-8022-7_14
Download citation
DOI: https://doi.org/10.1007/978-981-10-8022-7_14
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-8021-0
Online ISBN: 978-981-10-8022-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)