Skip to main content
SpringerLink
Log in
Book cover

Microbial Biotechnology pp 141–152Cite as

Probiotics: The Ultimate Nutritional Supplement

  • Chapter
  • First Online:

Abstract

Microorganism live inside the human body and thus the human are inimitable reservoir for diverse and vibrant group of microbes . These microbial species primarily modulates the host internal environment for the edification in the host health. This spectacular symbiotic relationship is under extensive research in recent years. The significance of these organisms in various metabolic activities inside the body is very crucial. Therefore any alterations in their diversity may results in several fatal diseases and disorders. The efficacy of the classical therapy is consecutively demising with the emergence of tolerance as well as resistance to these therapeutic drugs. Henceforth, a simple, cheaper, receptive and intrinsic means for health benefactor is a vital compulsion of the present era which could be achieved by the means of probiotics. Research have proved that probiotics supplementation against various enteric pathogens has shown promising results with their exceptional ability to compete with pathogenic microbes for various purposes by initiating the activation of specific genes of localized host cells. In the current chapter, the beneficial effect of probiotics consumption in human health and medical sectors has been discussed.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Akelma AZ, Topcu ZIK (2016) Probiotics and allergic disease. World J Immunol 6I:75–82

    Article  Google Scholar 

  • Ammor S, Tauveron G, Dufour E, Chevallier I (2006) Antibacterial activity of lactic acid bacteria against spoilage and pathogenic bacteria isolated from the same meat small-scale facility: screening and characterization of the antibacterial compounds. Food Control 17:454–461

    Article  CAS  Google Scholar 

  • Bakirtzi K, Law IKM, Xue X et al (2016) Neurotensin promotes the development of colitis and intestinal angiogenesis via Hif-1α–miR-210 signaling. J Immunol 196:4311–4321

    Article  CAS  Google Scholar 

  • Barrett HL, Callaway LK, Nitert MD (2012) Probiotics: a potential role in the prevention of gestational diabetes? Acta Diabetol 49:1–13

    Article  Google Scholar 

  • Barz ML, Anhe FF, Varin TV (2015) Probiotics as complementary treatment for metabolic disorders. Diabetes Metab J 39:291–303

    Article  Google Scholar 

  • Bongaerts GPA, Severijnen RSVM (2016) A reassessment of the PROPATRIA study and its implications for probiotic therapy. Nat Biotechnol 34:55–63

    Article  CAS  Google Scholar 

  • Cammarota G, Ianiro G, Cianci R et al (2015) The involvement of gut microbiota in inflammatory bowel disease pathogenesis: potential for therapy. Pharmacol Ther 149:191–212

    Article  CAS  Google Scholar 

  • Cammarota G, Pecere S, Ianiro G et al (2016) Principles of DNA-based gut microbiota assessment and therapeutic efficacy of fecal microbiota transplantation in gastrointestinal diseases. Dig Dis 34:279–285

    Article  Google Scholar 

  • Chan PA, Robinette A, Montgomery M et al (2016) Extragenital infections caused by Chlamydia trachomatis and Neisseria gonorrhoeae: a review of the literature. Infect Dis Obstet Gynecol 5758387:17

    Google Scholar 

  • Chen X, Yang G, Song J-H et al (2013) Probiotic yeast inhibits VEGFR signaling and angiogenesis in intestinal inflammation. PLoS One 8:1–7

    Article  CAS  Google Scholar 

  • Curro D, Ianiro G, Pecere S et al (2016) Probiotics, fiber and herbal medicinal products for functional and inflammatory bowel disorders. Brit J Pharmacol 173:61–68

    Google Scholar 

  • Figueroa-Gonzalez I, Cruz-Guerrero A, Quijano G (2011) The benefits of probiotics on human health. J Microb Biochem Technol S1:003

    Google Scholar 

  • Fuller R (1989) Probiotics in man and animals. J Appl Bacteriol 66:365–378

    Article  CAS  Google Scholar 

  • Gayathri D, Rashmi BS (2016) Anti-cancer properties of probiotics: a natural strategy for cancer prevention. EC Nutr 5:1191–1202

    Google Scholar 

  • Gibson GR, Roberfroid MB (1995) Dietary modulation of the human colonie microbiota: introducing the concept of prebiotics. J Nutr 125:1401–1412

    Article  CAS  Google Scholar 

  • Gowri RS, Meenambigai P, Prabhavathi P et al (2016) Probiotics and its effects on human health-a review. Int J Curr Microbiol Appl Sci 5:384–392

    Article  CAS  Google Scholar 

  • Hamasalim HJ (2016) Synbiotic as feed additives relating to animal health and performance. Adv Microbiol 6:288–302

    Article  CAS  Google Scholar 

  • Hanson L, Vusse LV, Jerme M et al (2016) Probiotics for treatment and prevention of urogenital infections in women: a systematic review. J Midwifery Womens Health 61:339–355

    Article  Google Scholar 

  • Hartstra AV, Bouter KEC, Backhed F, Nieuwdorp M (2015) Insights into the role of the microbiome in obesity and type 2 diabetes. Diabetes Care 38:159–165

    Article  CAS  Google Scholar 

  • Hu C, Wong FS, Wen L (2015) Type 1 diabetes and gut microbiota: friend or foe? Pharmacol Res 98:9–15

    Article  CAS  Google Scholar 

  • Iqbal MZ, Qadir MI, Hussain T et al (2014) Probiotics and their beneficial effects against various diseases. Pak J Pharm Sci 27:405–415

    PubMed  Google Scholar 

  • Islam SU (2016) Clinical uses of probiotics. Medicine 95:1–5

    Article  Google Scholar 

  • Kahouli I, Malhotra M, Alaoui-Jamali MA, Prakash S (2015) In-vitro characterization of the anti-cancer activity of the probiotic bacterium Lactobacillus fermentum NCIMB 5221 and potential against colorectal cancer cells. J Cancer Sci Ther 7:224–235

    CAS  Google Scholar 

  • Kang J-H, Yun S-I, Park M-H et al (2013) Anti-obesity effect of Lactobacillus gasseri BNR17 in high-sucrose diet-induced obese mice. PLoS One 8:1–8

    Article  Google Scholar 

  • Kareem KY, Ling FH, Chwen LT et al (2014) Inhibitory activity of postbiotic produced by strains of Lactobacillus plantarum using reconstituted media supplemented with inulin. Gut Pathog 6:1–7

    Article  Google Scholar 

  • Karimi G, Sabran MR, Jamaluddin R et al (2015) The anti-obesity effects of Lactobacillus casei strain shirota versus orlistat on high fat diet-induced obese rats. Food Nutr Res 59:1–8

    Article  Google Scholar 

  • Kobyliak N, Conte C, Cammarota G et al (2016) Probiotics in prevention and treatment of obesity: a critical view. Nutr Metab 13:1–13

    Article  Google Scholar 

  • Kristensen NB, Bryrup T, Allin KH et al (2016) Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials. Genome Med 8:1–11

    Article  Google Scholar 

  • Larsen N, Vogensen FK, vanden Berg FW et al (2010) Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One 5:1–10

    Google Scholar 

  • Lewis BB, Buffie CG, Carter R et al (2015) Loss of microbiota-mediated colonization resistance to Clostridium difficile infection is greater following oral vancomycin as compared with metronidazole. J Infect Dis 212:1656–1665

    Article  CAS  Google Scholar 

  • Lilly DM, Stillwell RH (1965) Growth promoting factors produced by probiotics. Science 147:747–748

    Article  CAS  Google Scholar 

  • Ljungberg M, Korpela R, Ilonen J et al (2006) Probiotics for the prevention of beta cell autoimmunity in children at genetic risk of type-1 diabetes-the PRODIA study. Ann N Y Acad Sci 1079:360–364

    Article  Google Scholar 

  • Mayer EA, Tillisch K, Gupta A (2015) Gut/brain axis and the microbiota. J Clin Invest 125:926–938

    Article  Google Scholar 

  • Messaoudi M, Lalonde R, Violle N et al (2010) Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br J Nutr 105:755–764

    Article  Google Scholar 

  • Metchnikoff E, Mitchell PC (1907) Essais optimistes. Heinemann, London

    Google Scholar 

  • Ooi MF, Mazlan N, Foo HL et al (2015) Effects of carbon and nitrogen sources on bacteriocin-inhibitory activity of postbiotic metabolites produced by Lactobacillus plantarum I-UL4. Malays J Microbiol 11:176–184

    CAS  Google Scholar 

  • Palumbo VD, Marcello R, Gammazza AM et al (2016) The long-term effects of probiotics in the therapy of ulcerative colitis: a clinical study. Biomed Pap 160:372–377

    Article  Google Scholar 

  • Patel RM, Denning PW (2013) Therapeutic use of prebiotics, probiotics, and postbiotics to prevent necrotizing enterocolitis: what is the current evidence? Clin Perinatol 40:11–25

    Article  Google Scholar 

  • Perez-Cobas AE, Moya A, Gosalbes MJ, Latorre A (2015) Colonization resistance of the gut microbiota against Clostridium difficile. Antibiotics 4:337–357

    Article  CAS  Google Scholar 

  • Rao AV, Bested AC, Beaulne TM et al (2009) A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome. Gut Pathog 1:1–6

    Article  Google Scholar 

  • Rao SC, Athalye-Jape GK, Deshpande GC et al (2016) Probiotic supplementation and late-onset sepsis in preterm infants: a meta-analysis. Pediatrics 137:1–16

    Article  Google Scholar 

  • Shahverdi E (2016) Probiotics and gastrointestinal diseases. Int J Dig Dis 2:1–2

    Google Scholar 

  • Simova ED, Beshkova DB, Dimitrov P (2009) Characterization and antimicrobial spectrum of bacteriocins produced by lactic acid bacteria isolated from traditional Bulgarian dairy products. J Appl Microbiol 106:692–701

    Article  CAS  Google Scholar 

  • Song S, Lee SJ, Park D-J et al (2016) The anti-allergic activity of Lactobacillus plantarum L67 and its application to yogurt. J Dairy Res 99:9372–9382

    CAS  Google Scholar 

  • Spiller R (2016) Irritable bowel syndrome: new insights into symptom mechanisms and advances in treatment. F1000Research 5:1–11

    Article  Google Scholar 

  • Takeda S, Hidaka M, Yoshida H et al (2016) Antiallergic activity of probiotics from Mongolian dairy products on type I allergy in mice and mode of antiallergic action. J Funct Foods 9:60–69

    Article  Google Scholar 

  • Tejero-Sarinena S, Barlow J, Costabile A et al (2013) Antipathogenic activity of probiotics against Salmonella Typhimurium and Clostridium difficile in anaerobic batch culture systems: is it due to synergies in probiotic mixtures or the specificity of single strains? Anaerobe 24:60–65

    Article  CAS  Google Scholar 

  • Tillisch K (2014) The effects of gut microbiota on CNS function in humans. Gut Microbes 5:404–410

    Article  Google Scholar 

  • Tissier H (1906) Tritement des infections intestinales par la methode de translormation de la flore bacterienne de lintestin. C R Soc Biol 60:359–361 (in French)

    Google Scholar 

  • Umbrello G, Esposito S (2016) Microbiota and neurologic diseases: potential effects of probiotics. J Transl Med 14:1–11

    Article  Google Scholar 

  • Vafaeie F (2016) Critical review on probiotics and its effect on cancer. Cancer Press 2:30–34

    Article  Google Scholar 

  • Vidya S, Thiruneelakandan G (2015) Probiotic potentials of lactobacillus and its anti-cancer activity. Int J Curr Res 7:20680–20684

    CAS  Google Scholar 

  • Waigankar SS, Patel V (2011) Role of probiotics in urogenital healthcare. J Midlife Health 2:5–10

    PubMed  PubMed Central  Google Scholar 

  • World Health Organization (2017) Cancer fact sheet 2017. World Health Organization, Geneva

    Google Scholar 

  • Yoo J, Kim S (2016) Probiotics and prebiotics: present status and future perspectives on metabolic disorders. Forum Nutr 8:1–20

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. P.G. Department of Biotechnology, Academy of Management and Information Technology, Khurda, Odisha, India

    Rout George Kerry & Pratima Pradhan

  2. Guruji Foods and Beverages, HSIIDC Barhi, Sonipat, Haryana, India

    Dibyaranjan Samal

  3. Amity Institute of Wildlife Science, Amity University, Noida, Uttar Pradesh, India

    Sushanto Gouda

  4. Research Institute of Biotechnology and Medical Converged Science, Dongguk University, Goyang-si, Gyeonggi-do, South Korea

    Gitishree Das & Jayanta Kumar Patra

  5. Department of Food Science and Biotechnology, Dongguk University, Goyang, Gyeonggi-do, South Korea

    Han-Seung Shin

Authors
  1. Rout George Kerry
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pratima Pradhan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dibyaranjan Samal
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sushanto Gouda
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Gitishree Das
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Han-Seung Shin
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jayanta Kumar Patra
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jayanta Kumar Patra .

Editor information

Editors and Affiliations

  1. Dongguk University, Goyang-si, Korea (Republic of)

    Jayanta Kumar Patra

  2. Dongguk University, Goyang-si, Korea (Republic of)

    Gitishree Das

  3. Dongguk University, Goyang-si, Korea (Republic of)

    Han-Seung Shin

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Kerry, R.G. et al. (2018). Probiotics: The Ultimate Nutritional Supplement. In: Patra, J., Das, G., Shin, HS. (eds) Microbial Biotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-10-7140-9_7

Download citation

Publish with us

Policies and ethics

Search

Navigation