Abstract
Survival rates have improved considerably, but respiratory complications remain a major problem in population with spinal cord injuries. Spinal cord injury has a significant effect on lung function. Respiratory complications pose a serious threat to patients with spinal cord injuries, and death from respiratory disease is a major cause of mortality. Pneumonia is a leading cause of death after spinal cord injury, while atelectasis, ventilatory failure, and pulmonary embolism are common causes of morbidity. These respiratory problems cannot be recognized as quickly in patients with spinal cord injuries as in normally innervated individuals. Pulmonary complications are more common in patients with spinal cord injury with higher level lesions, reduced spirometry (FEV1 and FVC), impaired gas exchange (lower PaO2), and advanced age. A high spinal cord injury above the fifth cervical level usually results in a severe impairment of the respiratory function. To minimize morbidity and mortality, patients with tetraplegia need continuous preventive measures, careful surveillance, prompt diagnosis, and appropriate treatment of respiratory complications. If a patient survives an acute stage of respiratory distress, chronic problems that may lead to a complication of the respiratory system may occur. It is important for the clinician to understand the muscles and normal mechanics of respiration before evaluating the respiratory status of the patient and establishing treatment goals.
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References
Akhtar SR. Practice variation in respiratory therapy documentation during mechanical ventilation. Chest. 2003;124:2275–82.
Andrews J, Sathe NA, Krishnaswami S, et al. Nonpharmacologic airway clearance techniques in hospitalized patients: a systematic review. Respir Care. 2013;58:2160–86.
Arora S, Flower O, Murray NP, et al. Respiratory care of patients with cervical spinal cord injury: a review. Crit Care Resusc. 2012;14:64–73.
Bach JR. Pulmonary rehabilitation in neuromuscular disorders. Semin Respir Med. 1993;14:515.
Bach JR. Noninvasive respiratory management of high level spinal cord injury. J Spinal Cord Med. 2012;35:72–80.
Bach JR, Saporito LR. Criteria for extubation and tracheostomy tube removal for patients with ventilatory failure: a different approach to weaning. Chest. 1996;110:1566–157.
Bach JR, Tilton MC. Life satisfaction and well-being measures in ventilator assisted individuals with traumatic tetraplegia. Arch Phys Med Rehabil. 1994;75:626–32.
Bach JR, Alba AS, Saporito LA. Intermittent positive pressure ventilation via the mouth as an alternative to tracheostomy for 257 ventilator users. Chest. 1993;103:174–82.
Ball PA. Critical care of spinal cord injury. Spine (Phila Pa 1976). 2001;26(234 Suppl):S27–30.
Bauman KA, Kurili A, Schotland HM, et al. Simplified approach to diagnosing sleep-disordered breathing and nocturnal hypercapnia in individuals with spinal cord injury. Arch Phys Med Rehabil. 2016;97:363–71.
Berlowitz DJ, Wadsworth B, Ross J. Respiratory problems and management in people with spinal cord injury. Breathe (Sheff). 2016;12:328–40.
Biering-Sørensen F, Jennum P, Laub M. Sleep disordered breathing following spinal cord injury. Respir Physiol Neurobiol. 2009;169:165–70.
Biering-Sørensen F, Krassioukov A, Alexander MS, et al. International spinal cord injury pulmonary function basic data set. Spinal Cord. 2012;50:418–21.
Braun NM, Arora NS, Rochester DF. Respiratory muscle and pulmonary function in polymyositis and other proximal myopathies. Thorax. 1983;38:616–23.
Brower RG, Matthay MA, Morris A, et al. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000;342:1301–8.
Brown R, DiMarco AF, Hoit JD, Garshick E. Respiratory dysfunction and management in spinal cord injury. Respir Care. 2006;51:853–68; discussion 869–70.
Burns SP. Acute respiratory infections in persons with spinal cord injury. Phys Med Rehabil Clin N Am. 2007;18:203–16.
Burns SM. Weaning from mechanical ventilation: where were we then, and where are we now? Crit Care Nurs Clin North Am. 2012;24:457–68.
Chatwin M, Toussaint M, Gonçalves MR, et al. Airway clearance techniques in neuromuscular disorders: a state of the art review. Respir Med. 2018;136:98–110.
Chiodo AE, Sitrin RG, Bauman KA. Sleep disordered breathing in spinal cord injury: a systematic review. J Spinal Cord Med. 2016;39:374–82.
Choi HJ, Paeng SH, Kim ST, et al. The effectiveness of early tracheostomy (within at least 10 days) in cervical spinal cord injury patients. J Korean Neurosurg Soc. 2013;54:220–4.
Consortium of Spinal Cord Medicine. Respiratory management following spinal cord injury. Clinical practice guidelines for health-care professionals. Washington, DC: Paralyzed Veterans of America; 2005.
Eskandar N, Apostolakos MJ. Weaning from mechanical ventilation. Crit Care Clin. 2007;23:263–74.
Estenne M, De Troyer A. Mechanism of the postural dependence of vital capacity in tetraplegic subjects. Am Rev Respir Dis. 1987;135:367–71.
Evans CT, Weaver FM, Rogers TJ, et al. Guideline-recommended management of community-acquired pneumonia in veterans with spinal cord injury. Top Spinal Cord Inj Rehabil. 2012;18:300–5.
Fromm B, Hundt G, Gemer HJ, et al. Management of respiratory problems unique to high tetraplegia. Spinal Cord. 1999;37:239–44.
Fuller DD, Lee KZ, Tester NJ. The impact of spinal cord injury on breathing during sleep. Respir Physiol Neurobiol. 2013;188:344–54.
Gali B, Goyal DG. Positive pressure mechanical ventilation. Emerg Med Clin N Am. 2003;21:453–73.
Goldmann JM, Willians SJ, Denison DM. The rib cage and abdominal components of respiratory system compliance in tetraplegic patients. Eur Respir J. 1988;1:242–7.
Gounden P. Static respiratory pressures in patients with post-traumatic tetraplegia. Spinal Cord. 1997;35:43–7.
Grant RA, Quon JL, Abbed KM. Management of acute traumatic spinal cord injury. Curr Treat Options Neurol. 2015;17:334.
Grimm DR, Chandy D, Almenoff PL, et al. Airway hyperreactivity in subjects with tetraplegia is associated with reduced baseline airway caliber. Chest. 2000;118:1397–404.
Haitsma JJ. Physiology of mechanical ventilation. Crit Care Clin. 2007;23:117–34.
Hess DR. The evidence for secretion clearance technique. Respir Care. 2001;46:1276–93.
Hess DR. Facilitating speech in a patient with tracheostomy. Respir Care. 2005;50:519–25.
Hoit JD, Banzett RB, Lohmeier HL, et al. Clinical ventilator adjustments that improve speech. Chest. 2003;124:1512–21.
Huang CT, Yu CJ. Conventional weaning parameters do not predict extubation outcome in intubated subjects requiring prolonged mechanical ventilation. Respir Care. 2013;58:1307–14.
Jia X, Kowalski RG, Sciubba DM, et al. Critical care of traumatic spinal cord injury. J Intensive Care Med. 2013;28:12–23.
Kelley A. Spirometry testing standards in spinal cord injury. Chest. 2003;123:725–30.
Kelly BJ, Luce JM. The diagnosis and management of neuromuscular diseases causing respiratory failure. Chest. 1991;99:1485–94.
LaVela SL, Burns SP, Goldstein B, et al. Dysfunctional sleep in persons with spinal cord injuries and disorders. Spinal Cord. 2012;50:682–5.
Linn WS, Adkins RH, Gong H Jr, et al. Pulmonary function in chronic spinal cord injury: a cross-sectional survey of 222 southern California adult outpatients. Arch Phys Med Rehabil. 2000;81:757–63.
Linn WS, Spungen AM, Gong H Jr, et al. Forced vital capacity in two large outpatient populations with chronic spinal cord injury. Spinal Cord. 2001;39:263–8.
Mahler DA. Pulmonary rehabilitation. Chest. 1998;113:263S–8S.
McGrath B, Lynch J, Wilson M, et al. A novel technique for communication in the ventilator-dependent tracheostomy patient. J Intensive Care Soc. 2016;17:19–26.
Montgomerie JZ. Infections in patients with spinal cord injuries. Clin Infect Dis. 1997;25:1285–90.
Mueller G, Hopman MT, Perret C. Comparison of respiratory muscle training methods in individuals with motor complete tetraplegia. Top Spinal Cord Inj Rehabil. 2012;18:118–21.
Mueller G, Hopman MT, Perret C. Comparison of respiratory muscle training methods in individuals with motor and sensory complete tetraplegia: a randomized controlled trial. J Rehabil Med. 2013;45:248–53.
Muir JF. Pulmonary rehabilitation in chronic respiratory insufficiency. 5. Home mechanical ventilation. Thorax. 1993;48:1264–73.
O’Donohue WJ Jr, Giovannoni RM, Goldberg AI, et al. Long-term mechanical ventilation. Guidelines for management in the home and at alternate community sites. Report of the Ad Hoc Committee, Respiratory Care Section, American College of Chest Physicians. Chest. 1986;90(1 Suppl):1S–37S.
Peterson WP, Barbalata L, Brooks CA, et al. The effect of tidal volumes on the time to wean persons with high tetraplegia from ventilators. Spinal Cord. 1999;37:284–8.
Prigent H, Garguilo M, Pascal S, et al. Speech effects of a speaking valve versus external PEEP in tracheostomized ventilator-dependent neuromuscular patients. Intensive Care Med. 2010;36:1681–7.
Raurich JM, Rialp G, Ibanez J, et al. CO2 response and duration of weaning from mechanical ventilation. Respir Care. 2011;56:1130–6.
Reid WD, Brown JA, Konnyu KJ, et al. Physiotherapy secretion removal techniques in people with spinal cord injury: a systematic review. J Spinal Cord Med. 2010;33:353–70.
Restrepo RD, Wettstein R, Wittnebel L, et al. Incentive spirometry: 2011. Respir Care. 2011;56:1600–4.
Rezania K, Goldenberg FD, White S. Neuromuscular disorders and acute respiratory failure: diagnosis and management. Neurol Clin. 2012;30:161–85.
Ries AL, Bauldoff GS, Carlin BW, et al. Pulmonary rehabilitation: joint ACCP/AACVPR evidence-based clinical practice guidelines. Chest. 2007;131:4S–42S.
Romero FJ, Gambarrutta C, Garcia-Forcada A, et al. Long-term evaluation of phrenic nerve pacing for respiratory failure due to high cervical spinal cord injury. Spinal Cord. 2012;50:895–8.
Ross J, White M. Removal of the tracheostomy tube in the aspirating spinal cord-injured patient. Spinal Cord. 2003;41:636–42.
Ryken TC, Hurlbert RJ, Hadley MN, et al. The acute cardiopulmonary management of patients with cervical spinal cord injuries. Neurosurgery. 2013;72:84–92.
Sankari A, Badr MS. Diagnosis of sleep disordered breathing in patients with chronic spinal cord injury. Arch Phys Med Rehabil. 2016;97:176–7.
Schilero GJ, Spungen AM, Bauman WA, et al. Pulmonary function and spinal cord injury. Respir Physiol Neurobiol. 2009;166:129–41.
Schilero GJ, Bauman WA, Radulovic M. Traumatic spinal cord injury: pulmonary physiologic principles and management. Clin Chest Med. 2018;39:411–25.
Shavelle RM, DeVivo MJ, Strauss DJ, et al. Long-term survival of persons ventilator dependent after spinal cord injury. J Spinal Cord Med. 2006;29:511–9.
Shem K, Castillo K, Wong SL, et al. Dysphagia and respiratory care in individuals with tetraplegia: incidence, associated factors, and preventable complications. Top Spinal Cord Inj Rehabil. 2012;18:15–22.
Smith PE, Calverley RM, Edwards RH, et al. Practical problems in the respiratory care of patients with muscular dystrophy. N Eng J Med. 1987;316:1197–205.
Spungen AM, Grimm DR, Strakhan M, et al. Treatment with an anabolic agent is associated with improvement in respiratory function in persons with tetraplegia: a pilot study. Mt Sinai J Med. 1999;66:201–5.
Strickland SL, Rubin BK, Drescher GS, et al. AARC clinical practice guideline: effectiveness of nonpharmacologic airway clearance therapies in hospitalized patients. Respir Care. 2013;58:2187–93.
Tedde ML, Onders RP, Teixeira MJ, et al. Electric ventilation: indications for and technical aspects of diaphragmatic pacing stimulation surgical implantation. J Bras Pneumol. 2012;38:566–72.
Toki A, Hanayama K, Ishikawa Y. Resolution of tracheostomy complications by decanulation and conversion to noninvasive management for a patient with high-level tetraplegia. Top Spinal Cord Inj Rehabil. 2012;18:193–6.
Tow AM, Graves DE, Carter RE. Vital capacity in tetraplegics twenty years and beyond. Spinal Cord. 2001;39:139–44.
Walker DJ, Walterspacher S, Schlager D, et al. Characteristics of diaphragmatic fatigue during exhaustive exercise until task failure. Respir Physiol Neurobiol. 2011;176:14–20.
Walsh BK, Crotwell DN, Restrepo RD. Capnography/capnometry during mechanical ventilation. Respir Care. 2011;56:503–9.
Watt JW, Fraser MJ. The effect of insufflation leaks in long-term ventilation: waking and sleeping transcutaneous gas tensions in ventilator-dependent patients with an uncuffed tracheostomy tube. Anaesthesia. 1994;49:328–30.
Weidner N, Rupp R, Taney KE (eds). Neurological aspects of spinal cord injury. Springer, Cham; 2017
Wong SL, Shem K, Crew J. Specialized respiratory management for acute cervical spinal cord injury: a retrospective analysis. Top Spinal Cord Inj Rehabil. 2012;18:283–90.
Wright SE, Van Dahm K. Long-term care of the tracheostomy patient. Clin Chest Med. 2003;24:473–87.
Zakrasek EC, Nielson JL, Kosarchuk JJ, et al. Pulmonary outcomes following specialized respiratory management for acute cervical spinal cord injury: a retrospective analysis. Spinal Cord. 2017;55:559–65.
Suggested Readings
Cairo JM, editor. Pilbeam’s mechanical ventilation. Physiological and clinical applications. 5th ed. St. Louis, MO: Elesevier; 2016.
Campbell WW. DeJong’s the neurologic examination. 7th edn. New York: Wolters Kluwer Lippincott Williams & Wilkins; 1992.
Cardenas DD, Dalal K, editors. Spinal cord injury rehabilitation, Physical medicine and rehabilitation clinics of North America. Philadelphia, PA: Elsevier; 2014.
Cardenas DD, Hooton TM, editors. Medical complications in physical medicine and rehabilitation. New York: Demos Medical Publishing, LLC; 2015.
Chhabra HS, editor. ISCoS textbook on comprehensive management of spinal cord injuries. New Delhi: Wolters Kluwer; 2015.
Eltorai IM, Schmit JK, editors. Emergencies in chronic spinal cord injury patients. New York: Eastern Paralyzed Veterans Association; 2001.
Green D, Olson DA, editors. Medical management of long-term disability. 2nd ed. Boston, MA: Butterworth-Heinemann; 1996.
Hancox RJ, Whyte KF. Pocket guide to lung function tests. New York: The McGraw-Hill Companies, Inc.; 2001.
Harrison P. Managing spinal injury: critical care. The international management of people with actual or suspected spinal cord injury in high dependency and intensive care unit. London: The Spinal Injury Association; 2000.
Kennedy P, editor. The Oxford handbook of rehabilitation psychology. Oxford: Oxford University Press; 2012.
Kirshblum S, Campagnolo DI, editors. Spinal cord medicine. 2nd ed. Philadelphia, PA: Wolters Kluwer, Lippincott, Williams & Wilkins; 2011.
Preston RA. Acid-base, fluids and electrolytes: made ridiculously simple. 2nd ed. Miami, FL: MedMaster, Inc.; 2011.
Russel C, Matta B. Tracheostomy a multiprofessional handbook. Cambridge: Cambridge University Press; 2004.
Simonds AK, editor. Non-invasive respiratory support. A practical handbook. 3rd ed. London: CRC Press; 2007.
Sykes K, Yong JD. Respiratory support in intensive care. London: BMJ Books; 1999.
Young RR, Woolsey RM, editors. Diagnosis and management of disorders of the spinal cord. Philadelphia, PA: W. B. Saunders; 1995.
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Ko, HY. (2019). Respiratory Dysfunction. In: Management and Rehabilitation of Spinal Cord Injuries. Springer, Singapore. https://doi.org/10.1007/978-981-10-7033-4_18
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