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Role of STAT3 in Pancreatic Cancer: A Target for Therapy

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Book cover Role of Transcription Factors in Gastrointestinal Malignancies

Abstract

STAT3 is a member of the signal transducer and activator of transcription (STAT) family of proteins. Activation of the STAT3 signaling cascade results in the transcription of several pro-proliferative and anti-apoptotic proteins. STAT3 is also a potent modulator of the immune system, and its activation results in the suppression of the immune response. Dysregulation of STAT3 is implicated in the development and progression of a number of malignancies, including pancreatic ductal adenocarcinoma. Because of its involvement in tumorigenesis and the evasion of the immune response, STAT3 is emerging as a potential therapeutic target for pancreatic cancer, with several therapies currently under development.

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Author information

Author notes

  1. Waaqo B. Daddacha, Allyson E. Koyen and Ashley J. Schlafstein contributed equally to this work.

Authors and Affiliations

  1. Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA, USA

    Waaqo B. Daddacha, Allyson E. Koyen, Ashley J. Schlafstein & David S. Yu

Authors
  1. Waaqo B. Daddacha
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  2. Allyson E. Koyen
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  3. Ashley J. Schlafstein
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  4. David S. Yu
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Corresponding author

Correspondence to Waaqo B. Daddacha .

Editor information

Editors and Affiliations

  1. Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia, USA

    Ganji Purnachandra Nagaraju

  2. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

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© 2017 Springer Nature Singapore Pte Ltd

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Daddacha, W.B., Koyen, A.E., Schlafstein, A.J., Yu, D.S. (2017). Role of STAT3 in Pancreatic Cancer: A Target for Therapy. In: Nagaraju, G., Bramhachari, P. (eds) Role of Transcription Factors in Gastrointestinal Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-10-6728-0_24

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