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DNA Repair Disorders pp 41–47Cite as

Neurological Symptoms in Xeroderma Pigmentosum

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Abstract

In patients with xeroderma pigmentosum (XP), especially group A (XP-A), serious neurological complications are frequently observed. During the second decade of life, the both central and peripheral nervous systems become severely deteriorated resulting in serious problems for daily activity and life expectancy. Brain MRI shows progressive atrophy in all components, such as the cerebral cortex, white matter, brainstem, and cerebellum, and nerve conduction studies reveal sensory dominant axonal neuropathy in all extremities. The precise mechanisms remain unclear and no effective treatments are available.

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Author information

Authors and Affiliations

  1. Division of Neurology, Kobe University Hospital, Kobe, Japan

    Fumio Kanda

  2. Division of Neurology, Kobe University Graduate School of Medicine, Kobe, Japan

    Takehiro Ueda

  3. Department of Dermatology, Graduate School of Medicine, Kobe University, Kobe, Hyogo, Japan

    Chikako Nishigori

Authors
  1. Fumio Kanda
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  2. Takehiro Ueda
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  3. Chikako Nishigori
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Corresponding author

Correspondence to Fumio Kanda .

Editor information

Editors and Affiliations

  1. Department of Dermatology, Graduate School of Medicine, Kobe University, Kobe, Japan

    Chikako Nishigori

  2. Biosignal Research Center, Kobe University, Kobe, Japan

    Kaoru Sugasawa

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© 2019 Springer Nature Singapore Pte Ltd.

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Kanda, F., Ueda, T., Nishigori, C. (2019). Neurological Symptoms in Xeroderma Pigmentosum. In: Nishigori, C., Sugasawa, K. (eds) DNA Repair Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-10-6722-8_3

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  • DOI: https://doi.org/10.1007/978-981-10-6722-8_3

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-6721-1

  • Online ISBN: 978-981-10-6722-8

  • eBook Packages: MedicineMedicine (R0)

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